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1.4.1.18: lysine 6-dehydrogenase

This is an abbreviated version!
For detailed information about lysine 6-dehydrogenase, go to the full flat file.

Word Map on EC 1.4.1.18

Reaction

L-lysine
+
NAD+
 +
H2O
=
(S)-2-amino-6-oxohexanoate
 +
NADH
 +
H+
 +
NH3

Synonyms

L-lysine 6-dehydrogenase, L-lysine 6-dehydrogenase (deaminating), L-lysine epsilon-dehydrogenase, Lys 6-DH, LysDH, lysine 6-dehydrogenase

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.1 With NAD+ or NADP+ as acceptor
                1.4.1.18 lysine 6-dehydrogenase

Temperature Stability

Temperature Stability on EC 1.4.1.18 - lysine 6-dehydrogenase

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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
100
purified recombinant enzyme, half-life is 180 min, the enzyme is highly thermostable and retaining full activity even after incubation for 50 min at 100°C at pH 7.5
30
at 30°C enzyme activity is kept for 3 days and 70% of the activity remains after 7 days
40
-
stable for 10 min in absence of L-lysine, unstable above 40°C
60
no loss of activity after 10 min at pH 7.2
65
approx. 25% loss of activity after 10 min at pH 7.2 in the absence of 5 mM lysine, no loss of activity in the presence of 5 mM lysine
70
approx. 55% loss of activity after 10 min at pH 7.2
80
complete loss of activity after 10 min at pH 7.2