1.3.99.23: all-trans-retinol 13,14-reductase
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For detailed information about all-trans-retinol 13,14-reductase, go to the full flat file.
Word Map on EC 1.3.99.23
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Synonyms
(13,14)-all-trans-retinol saturase, 13,14-dihydroretinol saturase, all-trans-13,14-dihydroretinol saturase, all-trans-retinol:all-trans-13,14-dihydroretinol saturase, rat mammary tumor 7, retinol saturase, RetSat, RetSat A, Rmt7
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Localization on EC 1.3.99.23 - all-trans-retinol 13,14-reductase
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LOCALIZATION 
ORGANISM
UNIPROT
COMMENTARY 
GeneOntology No.
LITERATURE
SOURCE
additional information
perinuclear staining in cells overexpressing RetSat and nuclear staining of endogenous RetSat in primary mouse hepatocytes are observed
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RetSat is predominantly in the endoplasmic reticulum (ER) where it colocalizes with the ER marker protein disulfide isomerase
the enzyme has an N-terminal signal peptide (aa 1-18), that targets the nascent protein to the membrane of the endoplasmic reticulum, and a dinucleotide-binding domain (aa 73-118). There are several hydrophobic stretches, such as aa 567-587, that may be transmembrane domains. RetSat is predominantly in the endoplasmic reticulum (ER) where it colocalizes with the ER marker protein disulfide isomerase
