1.3.99.23: all-trans-retinol 13,14-reductase

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For detailed information about all-trans-retinol 13,14-reductase, go to the full flat file.

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Synonyms

(13,14)-all-trans-retinol saturase, 13,14-dihydroretinol saturase, all-trans-13,14-dihydroretinol saturase, all-trans-retinol:all-trans-13,14-dihydroretinol saturase, rat mammary tumor 7, retinol saturase, RetSat, RetSat A, Rmt7

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.99 With unknown physiological acceptors

                1.3.99.23 all-trans-retinol 13,14-reductase

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Results	in table
4	Activating Compound
111	AA Sequence
6	Application
1	CAS Registry Number
8	Cloned(Commentary)
25	Cofactor
31	Disease/ Diagnostics
10	Expression
20	General Information
1	Inhibitors
9	Localization
3	Molecular Weight [Da]
28	Natural Substrates/ Products (Substrates)
18	Organism
1	Pathway
8	Protein Variants
1	Reaction
9	Reaction Type
17	Reference
47	Source Tissue
42	Substrates and Products (Substrate)
39	Synonyms
1	Systematic Name

Disease

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Disease on EC 1.3.99.23 - all-trans-retinol 13,14-reductase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Congenital Abnormalities

Identification of genes related to beak deformity of chickens using digital gene expression profiling.

25198128

Diabetes Mellitus, Type 2

Retinol Saturase: More than the Name Suggests.

32345479

Fatty Liver

Retinol saturase coordinates liver metabolism by regulating ChREBP activity.

28855500

Hyperglycemia

Retinol saturase coordinates liver metabolism by regulating ChREBP activity.

28855500

Insulin Resistance

Integration of heterogeneous expression data sets extends the role of the retinol pathway in diabetes and insulin resistance.

19786482

Insulin Resistance

Retinol Saturase: More than the Name Suggests.

32345479

Metabolic Diseases

Retinol saturase promotes adipogenesis and is downregulated in obesity.

19139408

Metabolic Syndrome

Retinol saturase coordinates liver metabolism by regulating ChREBP activity.

28855500

Obesity

Retinol saturase promotes adipogenesis and is downregulated in obesity.

19139408

Obesity, Abdominal

Quercetin Ameliorates Gut Microbiota Dysbiosis That Drives Hypothalamic Damage and Hepatic Lipogenesis in Monosodium Glutamate-Induced Abdominal Obesity.

33996881

Sarcoma

Case Report: Exome sequencing reveals recurrent RETSAT mutations and a loss-of-function POLDIP2 mutation in a rare undifferentiated tongue sarcoma.

29862022

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