1.3.98.3: coproporphyrinogen dehydrogenase

This is an abbreviated version!
For detailed information about coproporphyrinogen dehydrogenase, go to the full flat file.

Reaction

Synonyms

anaerobic coproporphyrinogen III oxidase, At5g63290, AtHEMN1, BtrN, CgoX, Coprogen oxidase, coproporphyrinogen III oxidase, coproporphyrinogen oxidase, coproporphyrinogenase, CPO, EC 1.3.99.22, HemN, HEMN1, HemW, More, oxidase, coproporphyrinogen, oxygen-independent coproporphyrinogen III oxidase, oxygen-independent coproporphyrinogen-III oxidase, oxygen-independent CPO, radical S-adenosyl-L-methionine dehydrogenase, radical SAM enzyme, Sll1876, Sll1917, viperin

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.98 With other, known, physiological acceptors

                1.3.98.3 coproporphyrinogen dehydrogenase

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Results	in table
2	Activating Compound
19389	AA Sequence
2	Application
1	CAS Registry Number
13	Cloned(Commentary)
29	Cofactor
4	Crystallization (Commentary)
427	Disease/ Diagnostics
1	Expression
16	General Information
8	Inhibitors
2	kcat/KM [mM/s]
7	KM Value [mM]
3	Localization
7	Metals/Ions
2	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
26	Organism
7	Pathway
3	pH Optimum
22	Protein Variants
13	Purification (Commentary)
5	Reaction
4	Reaction Type
25	Reference
1	Renatured (Commentary)
8	Source Tissue
33	Substrates and Products (Substrate)
7	Subunits
63	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
5	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.3.98.3 - coproporphyrinogen dehydrogenase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

coproporphyrinogen III + 2 S-adenosyl-L-methionine

protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine

7 entries

coproporphyrinogen III + S-adenosyl-L-methionine

protoporphyrinogen IX + CO2 + L-methionine + 5'-deoxyadenosine

2 entries

coproporphyrinogen-III + S-adenosyl-L-methionine

protoporphyrinogen IX + CO2 + L-methionine + 5'-deoxyadenosine

2 entries

additional information

?

-

Lactococcus lactis

-

HemW shows no coproporphyrinogen III oxidase activity in vivo or in vitro

724235

-

-

?

coproporphyrinogen III + 2 S-adenosyl-L-methionine

protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine

Escherichia coli

-

-

711348, 763891

-

-

?

coproporphyrinogen III + 2 S-adenosyl-L-methionine

protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine

Escherichia coli

-

via reaction intermediate harderoporphyrinogen, not isoharderoporphyrinogen

711348

-

-

?

coproporphyrinogen III + 2 S-adenosyl-L-methionine

protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine

Homo sapiens

-

-

712016

-

-

?

coproporphyrinogen III + 2 S-adenosyl-L-methionine

protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine

Rubrivivax gelatinosus

I0HU37

-

726009, 745799

-

-

?

coproporphyrinogen III + 2 S-adenosyl-L-methionine

protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine

Rubrivivax gelatinosus

-

-

745799

-

-

?

coproporphyrinogen III + 2 S-adenosyl-L-methionine

protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine

Staphylococcus aureus

-

-

765437

-

-

?

coproporphyrinogen III + 2 S-adenosyl-L-methionine

protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine

Synechocystis sp.

-

sll1876 encodes HemN operating under micro-oxic conditions

713258

-

-

?

coproporphyrinogen III + S-adenosyl-L-methionine

protoporphyrinogen IX + CO2 + L-methionine + 5'-deoxyadenosine

Vibrio vulnificus

-

-

739104

-

-

?

coproporphyrinogen III + S-adenosyl-L-methionine

protoporphyrinogen IX + CO2 + L-methionine + 5'-deoxyadenosine

Vibrio vulnificus ATCC 29307

-

-

739104

-

-

?

coproporphyrinogen-III + S-adenosyl-L-methionine

protoporphyrinogen IX + CO2 + L-methionine + 5'-deoxyadenosine

Escherichia coli

P32131

HemN catalyzes the essential conversion of coproporphyrinogen-III to protoporphyrinogen IX during heme biosynthesis

655340

-

-

?

coproporphyrinogen-III + S-adenosyl-L-methionine

protoporphyrinogen IX + CO2 + L-methionine + 5'-deoxyadenosine

Escherichia coli

-

HemN catalyzes the prepenultimate step in anaerobic heme biosynthesis

658501

-

-

?