1.3.98.1: dihydroorotate dehydrogenase (fumarate)
This is an abbreviated version!
For detailed information about dihydroorotate dehydrogenase (fumarate), go to the full flat file.
Word Map on EC 1.3.98.1
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1.3.98.1
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pyrimidine
-
leflunomide
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brequinar
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uridine
-
plasmodium
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falciparum
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ubiquinone
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teriflunomide
-
dhods
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1.3.3.1
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ump
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dihydro-orotate
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triazolopyrimidine
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atovaquone
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1.3.99.11
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dysostosis
-
analysis
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medicine
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acrofacial
- 1.3.98.1
- pyrimidine
- leflunomide
- brequinar
- uridine
- plasmodium
- falciparum
- ubiquinone
- teriflunomide
-
dhods
-
1.3.3.1
- ump
-
dihydro-orotate
- triazolopyrimidine
- atovaquone
-
1.3.99.11
- dysostosis
- analysis
- medicine
-
acrofacial
Reaction
Synonyms
(DHO) dehydrogenase, 4,5-L-dihydroorotate:oxygen oxidoreductase, ACT/DHOD, class 1A DHOD, class 1A DHODH, class 1A dihydroorotate dehydrogenase, DHOD, DHOD1, DHOD2, DHOD3, DHODA, DHOdehase, DHODH, DHODH-1A, dihydroorotate dehydrogenase, dihydroorotate dehydrogenase class 1A, Dihydroorotate oxidase, EC 1.3.3.1, LmDHODH, More, oxidase, dihydroorotate, TcDHOD
ECTree
1.3.98.1 dihydroorotate dehydrogenase (fumarate)Advanced search results
results (
results (Substrates Products
Substrates Products on EC 1.3.98.1 - dihydroorotate dehydrogenase (fumarate)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
dihydroorotate + 2,3-dimethoxy-5-methyl-6-(3-methyl-2-butenyl)-1,4-benzoquinone
orotate + reduced 2,3-dimethoxy-5-methyl-6-(3-methyl-2-butenyl)-1,4-benzoquinone
-
-
-
?
dihydroorotate + 2,6-dichloroindophenol
orotate + reduced 2,6-dichloroindophenol
-
-
-
?
dihydroorotate + 2,6-dichlorophenolindophenol
orotate + ?
-
-
-
-
?
dihydroorotate + 2,6-dichlorophenolindophenol
orotate + reduced 2,6-dichlorophenolindophenol
dihydroorotate + fumarate
orotate + succinate
-
prefers fumarate over ubiquinone-1
-
-
?
L-dihydroorotate + 2,6-dichlorophenolindophenol
orotate + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
L-dihydroorotate + mesaconate
orotate + 2-methylbutanedioate
-
-
-
-
?
S-dihydroorotate + 2,6-dichlorophenolindophenol
orotate + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
S-dihydroorotate + menadione
orotate + menadiol
-
20% activity with menadione compared to fumarate
-
-
?
(S)-dihydroorotate + acceptor
orotate + reduced acceptor
-
fumarate and ferricyanide tested as electron acceptors
-
?
(S)-dihydroorotate + acceptor
orotate + reduced acceptor
-
fumarate and ferricyanide tested as electron acceptors
-
?
(S)-dihydroorotate + acceptor
orotate + reduced acceptor
-
2,6-dichlorophenolindophenol, potassium hexacyanoferrate(III) and molecular oxygen used as electron acceptors
-
?
(S)-dihydroorotate + acceptor
orotate + reduced acceptor
-
fourth step in synthesis of pyrimidine nucleotides
-
?
(S)-dihydroorotate + acceptor
orotate + reduced acceptor
-
fourth step in UMP-biosynthesis
-
?
(S)-dihydroorotate + acceptor
orotate + reduced acceptor
-
preferred electron acceptors in the decreasing order: ferricyanide, 2,6-dichlorophenolindophenol, ubiquinone-0, fumarate and O2
-
?
(S)-dihydroorotate + acceptor
orotate + reduced acceptor
-
fourth step in synthesis of pyrimidine nucleotides
-
?
(S)-dihydroorotate + ferricyanide
orotate + ferrocyanide
-
-
-
?
(S)-dihydroorotate + ferricyanide
orotate + ferrocyanide
-
ferricyanide usually used as electon acceptor in the assay
-
?
(S)-dihydroorotate + fumarate
orotate + succinate
-
enzyme is responsible for biosynthesis of succinate and orotate
-
-
?
(S)-dihydroorotate + O2
orotate + H2O2
-
ferricyanide, 2,6-dichlorophenolindophenol, cytochrome c and quinones as alternate electron acceptor, with ferricyanide 12 times faster rate of catalysis than with air alone
-
?
(S)-dihydroorotate + O2
orotate + H2O2
-
different dihydroorotate isotopes tested for mechanistic and stereochemical analysis
-
?
(S)-dihydroorotate + O2
orotate + H2O2
-
ferricyanide, cytochrome c and 2,6-dichlorophenolindolphenol as alternate electron acceptor
-
?
(S)-dihydroorotate + O2
orotate + H2O2
-
redox dyes, 2,6-dichlorophenolindophenol, ferricyanide are most active electron acceptors, oxygen and cytochrome c are much slower
-
?
(S)-dihydroorotate + O2
orotate + H2O2
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pathway of pyrimidine biosynthesis, constitutive biosynthetic enzyme
-
?
(S)-dihydroorotate + O2
orotate + H2O2
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pathway of pyrimidine biosynthesis, constitutive biosynthetic enzyme
-
?
(S)-dihydroorotate + O2
orotate + H2O2
-
ferricyanide as alternate electron acceptor, enzyme produced regardless of the carbon source
-
?
(S)-dihydroorotate + O2
orotate + H2O2
-
ferricyanide, 2,6-dichlorophenolindophenol, cytochrome c and quinones as alternate electron acceptor, with ferricyanide 12 times faster rate of catalysis than with air alone
-
?
(S)-dihydroorotate + O2
orotate + H2O2
-
ferricyanide, 2,6-dichlorophenolindophenol, cytochrome c and quinones as alternate electron acceptor, with ferricyanide 12 times faster rate of catalysis than with air alone
-
?
dihydroorotate + 2,6-dichlorophenolindophenol
orotate + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
dihydroorotate + 2,6-dichlorophenolindophenol
orotate + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
dihydroorotate + acceptor
orotate + reduced acceptor
-
acceptor: 2,6-dichlorophenolindophenol
-
-
?
dihydroorotate + acceptor
orotate + reduced acceptor
-
not acceptors: NAD+, NADP+, coenzymes Q6, Q10, K2
-
-
?
dihydroorotate + acceptor
orotate + reduced acceptor
-
discussion of substrate binding and catalytic mechanism
-
-
?
dihydroorotate + acceptor
orotate + reduced acceptor
-
no substrate: dihydrouracil
-
-
?
dihydroorotate + acceptor
orotate + reduced acceptor
-
acceptors: potassium hexacyanoferrate(III), to a lower extent molecular oxygen
-
-
?
dihydroorotate + acceptor
orotate + reduced acceptor
-
acceptor: 2,6-dichlorophenolindophenol
-
-
?
dihydroorotate + acceptor
orotate + reduced acceptor
-
kinetic isotope effects
-
-
?
dihydroorotate + acceptor
orotate + reduced acceptor
-
acceptor: ferricyanide, coenzyme Q0, fumarate, molecular oxygen
-
-
?
dihydroorotate + fumarate
orotate + reduced fumarate
-
-
-
?
dihydrooxonate + acceptor
oxonate + reduced acceptor
-
fumarate and ferricyanide tested as electron acceptors
-
?
dihydrooxonate + acceptor
oxonate + reduced acceptor
-
fumarate and ferricyanide tested as electron acceptors
-
?
L-dihydroorotate + fumarate
orotate + succinate
-
fumarate is the most effective electron acceptor
-
-
?
L-dihydroorotate + fumarate
orotate + succinate
-
DHODH catalyzes a coupled redox reaction in which dihydroorotate is oxidized to orotate and fumarate is reduced to succinate
-
-
?
additional information
?
-
-
three-dimensional active site structure, profile of interactions for molecular recognition, interaction of DHODH with orotate via residues Asn212, Asn284, Ser215, Phe149, Lys100, Gly148, Asn217, Asn145, and Thr285, overview
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-
?
additional information
?
-
-
no acceptor: fumarate, NAD+, coenzymes ubiquinone-6, ubiquinone-10
-
-
?
additional information
?
-
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maleate, glutaconate, cis-aconitate, trans-aconitate, and cinnamate do not function as electron acceptor
-
-
?
additional information
?
-
-
does not perform electron transfer to menaquinone, Q0, Q1, Q2, QD, O2, or to NAD+
-
-
?
additional information
?
-
-
enzyme has methylviologen-fumarate reductase activity
-
-
?
