Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.3.8.8: long-chain acyl-CoA dehydrogenase

This is an abbreviated version!
For detailed information about long-chain acyl-CoA dehydrogenase, go to the full flat file.

Word Map on EC 1.3.8.8

Reaction

a long-chain acyl-CoA
+
electron-transfer flavoprotein
=
a long-chain trans-2,3-dehydroacyl-CoA
+
reduced electron-transfer flavoprotein

Synonyms

ACAD 9, AcdB, acyl-CoA dehydrogenase 9, BACH, CTE-II, EC 1.3.99.13, EC 1.3.99.3, LCAD, long chain acyl coenzyme A dehydrogenase, long chain acyl-CoA dehydrogenase, long-chain acyl-CoA dehydrogenase, long-chain acyl-CoA hydrolase, long-chain acyl-coenzyme A dehydrogenase, MCAD, medium long-chain acyl-CoA dehydrogenase, More, MTE-II, palmitoyl-CoA dehydrogenase, palmitoyl-coenzyme A dehydrogenase, PtmO4, type-II acyl-CoA thioesterase, very long chain acyl-CoA dehydrogenase, very long-chain acyl-CoA dehydrogenase, very-long-chain acyl-CoA dehydrogenase, very-long-chain acyl-coenzyme A dehydrogenase, VLCAD, VLMCAD

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.8 With a flavin as acceptor
                1.3.8.8 long-chain acyl-CoA dehydrogenase

Substrates Products

Substrates Products on EC 1.3.8.8 - long-chain acyl-CoA dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R/S)-2-methylpalmitoyl-CoA + electron-transfer flavoprotein
2,3-dehydro-2-methylpalmitoyl-CoA + reduced electron-transfer flavoprotein
show the reaction diagram
-
-
-
?
(S)-2-methylpentadecanoyl-CoA + electron-transfer flavoprotein
2-methyl-2-pentadecenoyl-CoA + reduced electron-transfer flavoprotein
show the reaction diagram
-
-
-
?
2,6-dimethylheptanoyl-CoA + oxidized flavin
2,3-dehydro-2,6-dimethylheptanoyl-CoA + reduced flavin
show the reaction diagram
-
specific LCAD substrate
-
-
?
2-methylheptanoyl-CoA + acceptor
?
show the reaction diagram
-
activity assay
-
-
?
3-keto-palmitoyl-CoA + acceptor
?
show the reaction diagram
-
-
-
-
?
4-cis-7-cis-decadienoyl-CoA + Meldola's Blue
2-trans-4,7-cis,cis-decatrienoyl-CoA + reduced meldola blue
show the reaction diagram
-
-
-
?
4-cis-decenoyl-CoA + Meldola's Blue
2-trans-4-cis-decadienoyl-CoA + reduced meldola blue
show the reaction diagram
-
-
-
?
5-cis-decenoyl-CoA + Meldola's Blue
2-trans-5-cis-decadienoyl-CoA + reduced meldola blue
show the reaction diagram
-
-
-
?
6-cis-decenoyl-CoA + Meldola's Blue
2-trans-6-cis-decadienoyl-CoA + reduced meldola blue
show the reaction diagram
-
-
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
show the reaction diagram
arachidonoyl-CoA + acceptor
? + reduced acceptor
show the reaction diagram
-
48.9% activity compared to the wild type enzyme
-
-
?
arachidonoyl-CoA + electron transfer flavoprotein
(2E,5Z,8Z,11Z,14Z)-2,5,8,11,14-eicosapentaenoyl-CoA + reduced electron transfer flavoprotein
show the reaction diagram
-
48.9% activity compared to palmitoyl-CoA
-
-
?
arachidonoyl-CoA + phenazine methosulfate
(2E,5Z,8Z,11Z,14Z)-2,5,8,11,14-eicosapentaenoyl-CoA + reduced phenazine methosulfate
show the reaction diagram
-
-
-
?
butyryl-CoA + electron-transfer flavoprotein
2-butenoyl-CoA + reduced electron-transfer flavoprotein
show the reaction diagram
butyryl-CoA + phenazine methosulfate
2-butenoyl-CoA + reduced phenazine methosulfate
show the reaction diagram
-
-
-
?
cis,cis,cis,cis-4,7,10,13-hexadecatetraenoyl-CoA + Meldola's Blue
2-trans-4,7,10,13-cis,cis,cis,cis-hexadecapentaenoyl-CoA + reduced meldola blue
show the reaction diagram
-
-
-
?
decanoyl-CoA + electron-transfer flavoprotein
2-decenoyl-CoA + reduced electron-transfer flavoprotein
show the reaction diagram
decanoyl-CoA + Meldola's Blue
2-decenoyl-CoA + reduced meldola blue
show the reaction diagram
-
-
trans-isomer
?
decanoyl-CoA + phenazine methosulfate
(2E)-2-decenoyl-CoA + reduced phenazine methosulfate
show the reaction diagram
docosanoyl-CoA + electron-transfer flavoprotein
2-docosenoyl-CoA + reduced electron-transfer flavoprotein
show the reaction diagram
docosanoyl-CoA + phenazine methosulfate
2-docosenoyl-CoA + reduced phenazine methosulfate
show the reaction diagram
dodecanoyl-CoA + electron-transfer flavoprotein
2-dodecenoyl-CoA + reduced electron-transfer flavoprotein
show the reaction diagram
dodecanoyl-CoA + Meldola's Blue
2-dodecenoyl-CoA + reduced meldola blue
show the reaction diagram
-
-
trans-isomer
?
dodecanoyl-CoA + phenazine methosulfate
(2E)-2-dodecenoyl-CoA + reduced phenazine methosulfate
show the reaction diagram
eicosanoyl-CoA + electron-transfer flavoprotein
trans-2-eicosenoyl-CoA + reduced electron-transfer flavoprotein
show the reaction diagram
eicosanoyl-CoA + phenazine methosulfate
trans-2-eicosenoyl-CoA + reduced phenazine methosulfate
show the reaction diagram
erucoyl-CoA + phenazine methosulfate
(2E,13Z)-2,13-docosadienoyl-CoA + reduced phenazine methosulfate
show the reaction diagram
-
-
-
?
hexanoyl-CoA + electron-transfer flavoprotein
2-hexenoyl-CoA + reduced electron-transfer flavoprotein
show the reaction diagram
hexanoyl-CoA + Meldola's Blue
(2E)-2-hexenoyl-CoA + reduced meldola blue
show the reaction diagram
-
-
trans-isomer
?
hexanoyl-CoA + phenazine methosulfate
2-hexenoyl-CoA + reduced phenazine methosulfate
show the reaction diagram
lauroyl-CoA + acceptor
2-dodecenoyl-CoA + reduced acceptor
show the reaction diagram
lineoyl-CoA + acceptor
2,9,12-octadecatrienoyl-CoA + reduced acceptor
show the reaction diagram
-
12.5% activity compared to the wild type enzyme
-
-
?
linolenoyl-CoA + phenazine methosulfate
(2E,6Z,9Z,12Z)2,6,9,12-octadecatetraenoyl-CoA + reduced phenazine methosulfate
show the reaction diagram
-
-
-
?
linoleoyl-CoA + acceptor
2,9,12-octadecatrienoyl-CoA + reduced acceptor
show the reaction diagram
-
-
-
-
?
linoleoyl-CoA + electron transfer flavoprotein
2,9,12-octadecatrienoyl-CoA + reduced electron transfer flavoprotein
show the reaction diagram
-
12.5% activity compared to palmitoyl-CoA
-
-
?
linoleoyl-CoA + phenazine methosulfate
(2E,9Z,12Z)-2,9,12-octadecatrienoyl-CoA + reduced phenazine methosulfate
show the reaction diagram
-
-
-
?
myristoyl-CoA + acceptor
2-tetradecenoyl-CoA + reduced acceptor
show the reaction diagram
-
-
-
-
?
myristoyl-CoA + acceptor
? + reduced acceptor
show the reaction diagram
-
51.1% activity compared to the wild type enzyme
-
-
?
myristoyl-CoA + acceptor
trans(2)-tetradecenoyl-CoA + reduced acceptor
show the reaction diagram
-
-
-
-
?
myristoyl-CoA + electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
51.1% activity compared to palmitoyl-CoA
-
-
?
octanoyl-CoA + acceptor
2-octenoyl-CoA + reduced acceptor
show the reaction diagram
-
-
-
-
?
octanoyl-CoA + acceptor
?
show the reaction diagram
octanoyl-CoA + electron-transfer flavoprotein
2-octenoyl-CoA + reduced electron-transfer flavoprotein
show the reaction diagram
octanoyl-CoA + Meldola's Blue
(2E)-2-octenoyl-CoA + reduced meldola blue
show the reaction diagram
-
-
trans-isomer
?
octanoyl-CoA + phenazine methosulfate
2-octenoyl-CoA + reduced phenazine methosulfate
show the reaction diagram
oleoyl-CoA + acceptor
(2E,9Z)-2,9-octadecadienoyl-CoA + reduced acceptor
show the reaction diagram
-
-
-
-
?
oleoyl-CoA + acceptor
2,9-octadecadienoyl-CoA + reduced acceptor
show the reaction diagram
oleoyl-CoA + electron transfer flavoprotein
2,9-octadecadienoyl-CoA + reduced electron transfer flavoprotein
show the reaction diagram
-
40.8% activity compared to palmitoyl-CoA
-
-
?
oleoyl-CoA + phenazine methosulfate
(2E,9Z)-2,9-octadecadienoyl-CoA + reduced phenazine methosulfate
show the reaction diagram
-
-
-
?
omega-phenyldecanoyl-CoA + phenazine methosulfate
10-phenyl-2-decenoyl-CoA + reduced phenazine methosulfate
show the reaction diagram
-
-
-
?
omega-phenyldodecanoyl-CoA + phenazine methosulfate
12-phenyl-2-dodecenoyl-CoA + reduced phenazine methosulfate
show the reaction diagram
-
-
-
?
palmitoleoyl-CoA + acceptor
(2E,9Z)-2,9-hexadecadienoyl-CoA + reduced acceptor
show the reaction diagram
-
34.8% activity compared to the wild type enzyme
-
-
?
palmitoleoyl-CoA + acceptor
?
show the reaction diagram
-
VLCAD activity assay
-
-
?
palmitoleoyl-CoA + electron transfer flavoprotein
(2E,9Z)-2,9-hexadecadienoyl-CoA + reduced electron transfer flavoprotein
show the reaction diagram
-
34.8% activity compared to palmitoyl-CoA
-
-
?
palmitoleoyl-CoA + phenazine methosulfate
(2E,9Z)-2,9-hexadecadienoyl-CoA + reduced phenazine methosulfate
show the reaction diagram
-
-
-
?
palmitoyl-CoA + acceptor
2,3-unsaturated-palmitoyl-CoA + reduced acceptor
show the reaction diagram
-
-
-
?
palmitoyl-CoA + acceptor
?
show the reaction diagram
palmitoyl-CoA + electron transfer flavoprotein
2-hexadecenoyl-CoA + reduced electron transfer flavoprotein
show the reaction diagram
-
100% activity with palmitoyl-CoA
-
-
?
palmitoyl-CoA + electron-transfer flavoprotein
(2E)-2-hexadecenoyl-CoA + reduced electron-transfer flavoprotein
show the reaction diagram
palmitoyl-CoA + electron-transfer flavoprotein
2-hexadecenoyl-CoA + reduced electron-transfer flavoprotein
show the reaction diagram
palmitoyl-CoA + Meldola's Blue
2-hexadecenoyl-CoA + reduced meldola blue
show the reaction diagram
-
-
trans-isomer
?
palmitoyl-CoA + phenazine methosulfate
2-hexadecenoyl-CoA + reduced phenazine methosulfate
show the reaction diagram
platensimycin ML1 + electron-transfer flavoprotein
?
show the reaction diagram
stearoyl-CoA + acceptor
2-octadecenoyl-CoA + reduced acceptor
show the reaction diagram
-
39% activity compared to the wild type enzyme
-
-
?
stearoyl-CoA + electron transfer flavoprotein
2-octadecenoyl-CoA + reduced electron transfer flavoprotein
show the reaction diagram
-
39.0% activity compared to palmitoyl-CoA
-
-
?
stearoyl-CoA + electron-transfer flavoprotein
2-octadecenoyl-CoA + reduced electron-transfer flavoprotein
show the reaction diagram
stearoyl-CoA + Meldola's Blue
2-octadecenoyl-CoA + reduced meldola blue
show the reaction diagram
-
-
trans-isomer
?
stearoyl-CoA + phenazine methosulfate
2-octadecenoyl-CoA + reduced phenazine methosulfate
show the reaction diagram
tetradecanoyl-CoA + electron-transfer flavoprotein
2-tetradecenoyl-CoA + reduced electron-transfer flavoprotein
show the reaction diagram
tetradecanoyl-CoA + Meldola's Blue
2-tetradecenoyl-CoA + reduced meldola blue
show the reaction diagram
-
-
trans-isomer
?
tetradecanoyl-CoA + phenazine methosulfate
2-tetradecenoyl-CoA + reduced phenazine methosulfate
show the reaction diagram
additional information
?
-