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1.3.8.8: long-chain acyl-CoA dehydrogenase

This is an abbreviated version!
For detailed information about long-chain acyl-CoA dehydrogenase, go to the full flat file.

Word Map on EC 1.3.8.8

Reaction

a long-chain acyl-CoA
+
electron-transfer flavoprotein
=
a long-chain trans-2,3-dehydroacyl-CoA
+
reduced electron-transfer flavoprotein

Synonyms

ACAD 9, AcdB, acyl-CoA dehydrogenase 9, BACH, CTE-II, EC 1.3.99.13, EC 1.3.99.3, LCAD, long chain acyl coenzyme A dehydrogenase, long chain acyl-CoA dehydrogenase, long-chain acyl-CoA dehydrogenase, long-chain acyl-CoA hydrolase, long-chain acyl-coenzyme A dehydrogenase, MCAD, medium long-chain acyl-CoA dehydrogenase, More, MTE-II, palmitoyl-CoA dehydrogenase, palmitoyl-coenzyme A dehydrogenase, PtmO4, type-II acyl-CoA thioesterase, very long chain acyl-CoA dehydrogenase, very long-chain acyl-CoA dehydrogenase, very-long-chain acyl-CoA dehydrogenase, very-long-chain acyl-coenzyme A dehydrogenase, VLCAD, VLMCAD

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.8 With a flavin as acceptor
                1.3.8.8 long-chain acyl-CoA dehydrogenase

Inhibitors

Inhibitors on EC 1.3.8.8 - long-chain acyl-CoA dehydrogenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-hexadecenoyl-CoA
-
-
2-mercaptoacetate
-
inhibition by administration in vivo
2-octynoyl-CoA
Ag+
1 mM, complete inhibition of the recombinant enzyme
AgNO3
-
strong inhibition of apo and holo forms at 0.1 mM
Cu2+
1 mM, complete inhibition of the recombinant enzyme
CuCl2
-
strong inhibition of apo and holo forms at 0.1 mM
Hg2+
1 mM, 61% inhibition of the recombinant enzyme
HgCl2
iodoacetic acid
-
50% inhibition of apoenzyme at 2 mM, not inhibitory for the holo form
Methylmercury chloride
-
strong inhibition of apo and holo forms at 1 mM
Methylmercury iodide
Mn2+
1 mM, 72% inhibition of the recombinant enzyme
N-ethylmaleimide
p-chloromercuribenzoate
-
inhibition of enzyme-catalyzed C-2 proton-deuteron exchange reactions
p-hydroxymercuribenzoate
-
strong inhibition of the apoenzyme at 0.1 mM, not inhibitory for the holo form even at higher concentrations like 1 mM
palmitoyl-CoA
-
inhibition by micelle formation at concentrations up to 0.004 mM, reversed by fatty acid free bovine serum albumin
Pb2+
1 mM, 23% inhibition of the recombinant enzyme
Zn2+
1 mM, 19% inhibition of the recombinant enzyme