1.3.8.7: medium-chain acyl-CoA dehydrogenase
This is an abbreviated version!
For detailed information about medium-chain acyl-CoA dehydrogenase, go to the full flat file.
Word Map on EC 1.3.8.7
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1.3.8.7
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carnitine
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beta-oxidation
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infant
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acylcarnitines
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children
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peroxisome
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urine
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mcadd
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inborn
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error
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proliferator-activated
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hypoglycemia
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acidurias
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triglyceride
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flavoproteins
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fad
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phenylketonuria
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octanoylcarnitine
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palmitoyltransferase
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acidemia
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glutaric
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octanoyl-coa
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octanoic
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hypoketotic
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nbs
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vlcad
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decompensation
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coma
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pparalpha
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methylmalonic
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isovaleric
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very-long-chain
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decanoic
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isovaleryl-coa
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syrup
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reye-like
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lethargy
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3-hydroxyacyl-coa
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maple
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homocystinuria
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guthrie
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biotinidase
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acadvl
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3-methylcrotonyl-coa
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phenylpropionic
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butyryl-coa
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alpha-proton
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medicine
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analysis
- 1.3.8.7
- carnitine
-
beta-oxidation
- infant
- acylcarnitines
- children
- peroxisome
- urine
-
mcadd
-
inborn
- error
-
proliferator-activated
- hypoglycemia
- acidurias
- triglyceride
- flavoproteins
- fad
- phenylketonuria
- octanoylcarnitine
- palmitoyltransferase
- acidemia
-
glutaric
- octanoyl-coa
-
octanoic
-
hypoketotic
- nbs
- vlcad
- decompensation
- coma
- pparalpha
-
methylmalonic
-
isovaleric
-
very-long-chain
-
decanoic
- isovaleryl-coa
- syrup
-
reye-like
- lethargy
- 3-hydroxyacyl-coa
-
maple
- homocystinuria
-
guthrie
- biotinidase
- acadvl
- 3-methylcrotonyl-coa
-
phenylpropionic
- butyryl-coa
-
alpha-proton
- medicine
- analysis
Reaction
Synonyms
ACAD-9, ACADM, ACD, acyl CoA dehydrogenase, acyl coenzyme A dehydrogenase, acyl dehydrogenase, acyl-CoA dehydrogenase, acyl-CoA dehydrogenase-9, dehydrogenase, acyl coenzyme A, EC 1.3.2.2, EC 1.3.99.3, FadE, fatty acyl coenzyme A dehydrogenase, fatty-acyl-CoA dehydrogenase, general ACAD, general acyl CoA dehydrogenase, LCAD, LipB, MCAD, MCADH, medium chain acyl-CoA dehydrogenase, medium chain-specific acyl-CoA oxidase, medium-chain acyl CoA dehydrogenase, medium-chain acyl-CoA dehydrogenase, medium-chain acyl-coenzyme A dehydrogenase, medium-chain coenzyme A dehydrogenase, pMCAD, PP_1893, PP_2039, PP_2048, PP_2437
ECTree
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Inhibitors
Inhibitors on EC 1.3.8.7 - medium-chain acyl-CoA dehydrogenase
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(S)-(+)-(Methylenecyclopropyl)acetyl-CoA
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stereospecific inactivation, faster inhibition with (R)-isomer than with (S)-isomer
1-ethyl-3(3-dimethylaminopropyl)-carbodiimide
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90-96% inhibition of activity with electron transfer flavoprotein, not with phenazine methosulfate
3-butynoyl-CoA
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concentration-dependent, progressive total inactivation, active site inhibitor
oct-4-en-2-ynoyl-CoA
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irreversible inhibitor, active-site directed, enzyme protected by 2-octenoyl-CoA
p-hydroxymercuribenzoate
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0.1 mM, almost complete inhibition of the apo-enzyme
(methylenecyclopropyl)acetyl-CoA
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biphasic inhibition of medium-chain acyl-CoA dehydrogenase, rapid initial inactivation for 2 min, half-life: 1.3 min, followed by a slower decline, 95% activity lost after 30 min, no inhibition of long-chain acyl-CoA dehydrogenase
(R)-(-)-(methylenecyclopropyl)acetyl-CoA
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0.0155 mM, almost complete inactivation after 5 min, stereospecific inactivation, faster inhibition with (R)-isomer than with (S)-isomer
(R)-(-)-(methylenecyclopropyl)acetyl-CoA
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both (R)- and (S)-stereoisomers are potent inhibitors, inactivation is nonstereospecific
2-octynoyl-CoA
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inactivation of the reduced dehydrogenase may involve a covalent adduct between dihydroflavin and 2-octynoyl-CoA
2-octynoyl-CoA
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mechanism-based inhibitor, suicide-substrate that modifies Glu401
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S-carboxymethylated enzyme binds octanoyl-CoA but can no longer be reduced by it
iodoacetic acid
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30 mM, half-live: 100 min, loss of 98% activity after 25 h, 0.12 mM octanoyl-CoA strongly protects, S-carboxmethylation of a single catalytically essential methionine inactivates the enzyme
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0.1 mM, strong inhibition, half-time of inactivation: 2 min, octanoyl-CoA protects
N-ethylmaleimide
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inhibitory to apo-enzyme, 2 mM, half-time of inactivation: 4 min, complete inactivation after 20 min
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not inhibited by ATP, ADP, GTP, GDP, FAD, NAD+, NADP+, carnitine, acetyl-CoA, succinyl-CoA, citrate, isocitrate, succinate, alpha-ketoglutarate, malate, fumarate
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additional information
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not inhibited by saturated and 2,3-unsaturated branched chain acyl-CoA compounds
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additional information
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not inhibited by trans-2,trans-4-octadienoyl-CoA and oct-2-en-4-ynoyl-CoA
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