1.3.5.2: dihydroorotate dehydrogenase (quinone)
This is an abbreviated version!
For detailed information about dihydroorotate dehydrogenase (quinone), go to the full flat file.
Word Map on EC 1.3.5.2
-
1.3.5.2
-
pyrimidine
-
falciparum
-
plasmodium
-
leflunomide
-
brequinar
-
uridine
-
malaria
-
arthritis
-
antimalarial
-
rheumatoid
-
dihydroorotase
-
salvage
-
teriflunomide
-
dhods
-
autoimmune
-
orotidine
-
ump
-
atovaquone
-
triazolopyrimidine
-
flavoenzyme
-
medicine
-
phosphoribosyltransferase
-
antirheumatic
-
coq
-
drug development
-
decylubiquinone
-
dmards
-
synthesis
-
species-selective
-
pyre
-
pharmacology
-
isoxazole
-
transcarbamoylase
-
5-fluoroorotate
- 1.3.5.2
- pyrimidine
- falciparum
- plasmodium
- leflunomide
- brequinar
- uridine
- malaria
- arthritis
-
antimalarial
-
rheumatoid
- dihydroorotase
-
salvage
- teriflunomide
-
dhods
- autoimmune
- orotidine
- ump
- atovaquone
- triazolopyrimidine
-
flavoenzyme
- medicine
-
phosphoribosyltransferase
-
antirheumatic
- coq
- drug development
- decylubiquinone
-
dmards
- synthesis
-
species-selective
-
pyre
- pharmacology
-
isoxazole
-
transcarbamoylase
- 5-fluoroorotate
Reaction
Synonyms
class 2 dihydroorotate dehydrogenases, DHO-DH, DHOD, DHODase, DHODH, dihydroorotate dehydrogenase, EC 1.3.99.11, ETH_00004975, hDHODH, HsDHODH, L-5,6-dihydroorotate:ubiquinone exidoreductase, PfDHODH
ECTree
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IC50 Value
IC50 Value on EC 1.3.5.2 - dihydroorotate dehydrogenase (quinone)
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0.000117 - 0.0925
(2Z)-2-cyano-3-cyclopropyl-3-hydroxy-N-[4-(trifluoromethyl)phenyl]prop-2-enamide
-
0.0002 - 0.0086
(2Z)-N-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide
-
0.00017 - 0.0062
(2Z)-N-[2'-chloro-3-(trifluoromethyl)biphenyl-4-yl]-2-cyano-3-hydroxybut-2-enamide
-
0.00385
1-(2-((3,4-dimethylphenyl)amino)-4-methylthiazol-5-yl)-ethanone
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.00394
1-(2-((3-chloro-4-methylphenyl)amino)-4-methylthiazol-5-yl)ethanone
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.01
1-(2-((3-fluoro-4-methylphenyl)amino)-4-methylthiazol-5-yl)ethanone
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.00365
1-(2-((4-(tert-butyl)phenyl)amino)-4-methylthiazol-5-yl)-ethanone
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.00193
1-(2-((4-bromo-3-(trifluoromethyl)phenyl)amino)-4-methylthiazol-5-yl)ethanone
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.01
1-(2-((4-bromophenyl)amino)-4-methylthiazol-5-yl)-ethanone
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.00235
1-(2-((4-chloro-3-(trifluoromethyl)phenyl)amino)-4-methylthiazol-5-yl)ethanone
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.01
1-(2-(anthracen-2-ylamino)-4-methylthiazol-5-yl)ethan-1-one
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000562
1-(4-methyl-2-(naphthalen-2-ylamino)thiazol-5-yl)ethan-1-one
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.00076
10-phenyl-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.000077
2,8-dimethyl-N-[4-(trifluoromethyl)phenyl]pyrrolo[1,2-a]pyrimidin-4-amine
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.007 - 0.021
2-(1,1-difluoroethyl)-5-methyl-N-[4-(pentafluoro-lambda6-sulfanyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
0.0000118
2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methyl-6-(trifluoromethyl)-1,7-naphthyridine-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000127
2-(2'-methoxy-[1,1'-biphenyl]-4-yl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.268
2-(2,3-bis(benzyloxy)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.34
2-(2,4-bis(benzyloxy)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.27
2-(3,4-bis(benzyloxy)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.148
2-(3,4-diisobutoxyphenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.449
2-(3-methoxy-4-propoxyphenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.0084
2-(4-(1H-imidazol-1-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000148
2-(4-(2-(trifluoromethyl)pyridin-3-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.00526
2-(4-(2-chloro-6-methylpyridin-3-yl)phenyl)-3-methyl-1,7-naphthyridine-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000184
2-(4-(2-chloro-6-methylpyridin-3-yl)phenyl)-3-methylquinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.0000262
2-(4-(2-chloro-6-methylpyridin-3-yl)phenyl)-6-fluoro-3-methylquinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000235
2-(4-(2-chloro-6-methylpyridin-3-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.0000542
2-(4-(2-chloropyridin-3-yl)phenyl)-3,6-dimethylquinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000259
2-(4-(2-chloropyridin-3-yl)phenyl)-3-methyl-1,7-naphthyridine-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000201
2-(4-(2-chloropyridin-3-yl)phenyl)-3-methyl-6-(trifluoromethyl)-1,7-naphthyridine-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.0000543
2-(4-(2-chloropyridin-3-yl)phenyl)-3-methylquinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.00000971
2-(4-(2-chloropyridin-3-yl)phenyl)-6-fluoro-3-methylquinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.0000327
2-(4-(2-chloropyridin-3-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.00248
2-(4-(2-fluoro-6-methylpyridin-3-yl)phenyl)-3-methylquinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000504
2-(4-(2-fluoropyridin-3-yl)phenyl)-3-methylquinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.00142
2-(4-(2-fluoropyridin-3-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000165
2-(4-(2-methoxypyridin-3-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.0000221
2-(4-(2-methylpyridin-3-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.00143
2-(4-(4-(trifluoromethyl)pyridin-3-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000373
2-(4-(4-methylpyridin-3-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.0125
2-(4-(6-fluoropyridin-3-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.467
2-(4-(benzyloxy)-3-methoxyphenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.00807
2-(4-(piperidin-1-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.0101
2-(4-(pyridin-2-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000391
2-(4-(pyridin-3-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.00755
2-(4-(pyridin-4-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.2
2-(4-(pyrimidin-2-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.34
2-(4-butoxy-3-methoxyphenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.944
2-(4-hydroxy-3-methoxyphenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.438
2-(4-isobutoxy-3-methoxyphenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.00279
2-([1,1'-biphenyl]-4-yl)-3-methyl-1,6-naphthyridine-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.0000283
2-([1,1'-biphenyl]-4-yl)-3-methyl-1,7-naphthyridine-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.00122
2-([1,1'-biphenyl]-4-yl)-3-methyl-1,8-naphthyridine-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.0000212
2-([1,1'-biphenyl]-4-yl)-3-methyl-6-(trifluoromethyl)-1,7-naphthyridine-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.0000754
2-([1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000051
2-([1,1'-biphenyl]-4-yl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.079
2-chloro-3-(methylamino)naphthalene-1,4-dione
Schistosoma mansoni
pH 8.2, 25°C
-
0.096
2-cyano-3-hydroxy-N-(2',3,3'-trichlorobiphenyl-4-yl)but-2-enamide
Toxoplasma gondii
-
pH 8.0, 30°C
0.0047
2-hydroxy-3-(4-methoxyanilino)naphthalene-1,4-dione
Schistosoma mansoni
pH 8.2, 25°C
-
0.00038
2-hydroxy-3-[4-(4-nitrophenyl)piperazin-1-yl]naphthalene-1,4-dione
Schistosoma mansoni
pH 8.2, 25°C
-
0.091
2-hydroxyethylidene-cyano acetic acid 4-trifluoromethyl anilide
Toxoplasma gondii
-
pH 8.0, 30°C
0.00105 - 0.0021
2-[(2,3-dihydro-1,4-benzodioxin-6-yl)amino]-3-hydroxynaphthalene-1,4-dione
-
0.000013 - 0.1
2-[(2,5-dichlorophenyl)sulfanyl]-5-ethyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol
0.000051 - 0.011
2-[(2,5-dichlorophenyl)sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol
0.0019 - 0.0065
2-[(3,4-dichlorophenyl)sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol
0.00044 - 0.0018
2-[4-(2,3-dichlorophenyl)piperazin-1-yl]-3-hydroxynaphthalene-1,4-dione
-
0.001
2-[[(4-chlorophenyl)methyl]sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.00144
3-(3,4-dihydro-2H-pyrimido[1,2-b][1,2]benzothiazol-9-yl)phenol
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.0079 - 0.0314
3-(3-methylbut-2-en-1-yl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl 4-methylbenzene-1-sulfonate
-
0.00181
4-(3,4-dihydro-2H-pyrimido[1,2-b][1,2]benzothiazol-9-yl)phenol
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00182
4-(6-imino-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-9-yl)benzamide
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00016
5,6-dimethyl-N-(naphthalen-2-yl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.00019
5-ethyl-N-(naphthalen-2-yl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.0017
5-methyl-7-(naphthalen-2-yloxy)[1,2,4]triazolo[1,5-a]pyrimidine
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.1
5-methyl-7-(naphthalen-2-ylsulfanyl)[1,2,4]triazolo[1,5-a]pyrimidine
Plasmodium falciparum
above, pH not specified in the publication, temperature not specified in the publication
0.00028 - 0.025
5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine
0.000015
6-chloro-2-(2'-fluorobiphenyl-4-yl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
0.0000744
6-chloro-2-(4-(2-chloro-6-methylpyridin-3-yl)phenyl)-3-methylquinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000036
6-chloro-2-(4-(2-chloropyridin-3-yl)phenyl)-3-methylquinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000165
6-chloro-2-(4-(2-fluoropyridin-3-yl)phenyl)-3-methylquinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.00331
6-fluoro-2-(4-(2-fluoro-6-methylpyridin-3-yl)phenyl)-3-methylquinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.0000794
6-fluoro-2-(4-(2-fluoropyridin-3-yl)phenyl)-3-methylquinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.1
6-methyl-N-phenyl-3aH-inden-4-amine
Plasmodium falciparum
above, pH not specified in the publication, temperature not specified in the publication
0.00129
8-(1,3,3a,4-tetrahydro-2-benzofuran-4-yl)-3,4-dihydro-2H-pyrimido[1,2-b][1,2]benzothiazole
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.0011
8-(1,8a-dihydronaphthalen-1-yl)-3,4-dihydro-2H-pyrimido[1,2-b][1,2]benzothiazole
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00153
8-(oxolan-2-yl)-3,4-dihydro-2H-pyrimido[1,2-b][1,2]benzothiazole
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00148
8-(pyridin-3-yl)-3,4-dihydro-2H-pyrimido[1,2-b][1,2]benzothiazole
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00094
8-(thiolan-3-yl)-3,4-dihydro-2H-pyrimido[1,2-b][1,2]benzothiazole
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.0013
9-(1-benzofuran-2-yl)-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00097
9-(2,3-dihydro-1,4-benzodioxin-6-yl)-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00118
9-(2-methoxyphenyl)-3,4-dihydro-2H-pyrimido[1,2-b][1,2]benzothiazole
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00115
9-(2-nitrophenyl)-3,4-dihydro-2H-pyrimido[1,2-b][1,2]benzothiazole
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00118
9-(2H-1,3-benzodioxol-5-yl)-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00152
9-(3-ethylphenyl)-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.0013
9-(4-nitrophenyl)-3,4-dihydro-2H-pyrimido[1,2-b][1,2]benzothiazole
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00107
9-(4-phenoxyphenyl)-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00096
9-(isoquinolin-6-yl)-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00085
9-(naphthalen-1-yl)-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00065
9-(naphthalen-2-yl)-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00068
9-phenyl-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00151
9-phenyl-3,4-dihydro-2H-pyrimido[1,2-b][1,2]benzothiazole
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00107
9-[(E)-2-phenylethenyl]-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00156
9-[3-[(propan-2-yl)oxy]phenyl]-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00096
9-[4-(methylsulfanyl)phenyl]-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00143
9-[4-(trifluoromethoxy)phenyl]-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.000026
ethyl 2-((2,3-dihydro-1h-inden-5-yl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.01
ethyl 2-((3'-methoxy-[1,1'-biphenyl]-4-yl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000174
ethyl 2-((3,4-dichlorophenyl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.001358
ethyl 2-((3,4-dimethylphenyl)amino)-4-methylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000058
ethyl 2-((3,4-dimethylphenyl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000393
ethyl 2-((3,5-dichlorophenyl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000311
ethyl 2-((3,5-difluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)-amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.01
ethyl 2-((3-chloro-4-((2-chloro-6-fluorobenzyl)oxy)phenyl)-amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000372
ethyl 2-((3-chloro-4-methylphenyl)amino)-4-cyclopropylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000969
ethyl 2-((3-chloro-4-methylphenyl)amino)-4-methylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000035
ethyl 2-((3-chloro-4-methylphenyl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.01
ethyl 2-((3-chloro-4-phenoxyphenyl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.01
ethyl 2-((3-fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.001987
ethyl 2-((3-fluoro-4-methylphenyl)amino)-4-methylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000049
ethyl 2-((3-fluoro-4-methylphenyl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.01
ethyl 2-((3-fluoro-[1,1'-biphenyl]-4-yl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.01
ethyl 2-((4-(benzyloxy)-3-chlorophenyl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000284
ethyl 2-((4-(tert-butyl)phenyl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.01
ethyl 2-((4-bromo-2-methylphenyl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000128
ethyl 2-((4-bromo-3-(trifluoromethyl)phenyl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.00907
ethyl 2-((4-bromophenyl)amino)-4-methylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.00604
ethyl 2-((4-chloro-3-(trifluoromethyl)phenyl)amino)-4-(cyclopropanecarboxamido)thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000131
ethyl 2-((4-chloro-3-(trifluoromethyl)phenyl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000239
ethyl 2-((4-chlorophenyl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.00144
ethyl 2-((4-methoxyphenyl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000453
ethyl 2-(anthracen-2-ylamino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.001108
ethyl 2-(benzo[d][1,3]dioxol-5-ylamino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000029
ethyl 2-(naphthalen-2-ylamino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.01
ethyl 2-([1,1'-biphenyl]-4-ylamino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.01
ethyl 4-(cyclopropanecarboxamido)-2-((3,4-dimethylphenyl)amino)thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000515
ethyl 4-(tert-butyl)-2-((3,4-dimethylphenyl)amino)thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000552
ethyl 4-(tert-butyl)-2-((3-chloro-4-methylphenyl)amino)-thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000652
ethyl 4-(tert-butyl)-2-((3-fluoro-4-methylphenyl)amino)-thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.00211
ethyl 4-amino-2-((3,4-dimethylphenyl)amino)thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.01
ethyl 4-amino-2-((4-chloro-3-(trifluoromethyl)phenyl)-amino)thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.00903
ethyl 4-benzamido-2-((3,4-dimethylphenyl)amino)thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.01
ethyl 4-benzamido-2-((4-chloro-3-(trifluoromethyl)phenyl)-amino)thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000325
ethyl 4-cyclopropyl-2-((3,4-dimethylphenyl)amino)thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000645
ethyl 4-cyclopropyl-2-((4-fluoro-3-methylphenyl)amino)-thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000887
ethyl 4-methyl-2-(naphthalen-2-ylamino)thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000408
ethyl 4-phenyl-2-((4-(trifluoromethyl)phenyl)amino)-thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000018
ethyl 4-phenyl-2-((5,6,7,8-tetrahydronaphthalen-2-yl)-amino)thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000784
ethyl 4-phenyl-2-(phenylamino)thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.05
methyl 2-(4-(4-(trifluoromethyl)pyridin-3-yl)phenyl)quinoline-4-carboxylate
Homo sapiens
pH 8.0, 22°C
-
0.2
methyl 2-(4-(piperidin-1-yl)phenyl)quinoline-4-carboxylate, methyl 2-(4-(pyridin-3-yl)phenyl)quinoline-4-carboxylate, methyl 2-(4-cyclohexylphenyl)quinoline-4-carboxylate, methyl 2-([1,1'-biphenyl]-4-yl)quinoline-4-carboxylate
Homo sapiens
pH 8.0, 22°C
-
0.00143
methyl 3-(3,4-dihydro-2H-pyrimido[1,2-b][1,2]benzothiazol-9-yl)benzoate
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00115
methyl 4-(3,4-dihydro-2H-pyrimido[1,2-b][1,2]benzothiazol-9-yl)benzoate
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00122
methyl 4-(6-imino-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-9-yl)benzoate
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.1
N-(2-chlorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Plasmodium falciparum
above, pH not specified in the publication, temperature not specified in the publication
0.1
N-(2-fluorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Plasmodium falciparum
above, pH not specified in the publication, temperature not specified in the publication
0.06
N-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide
Toxoplasma gondii
-
pH 8.0, 30°C
0.00078
N-(4-bromophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.019
N-(4-fluorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.003
N-(anthracen-2-yl)-N,5-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.00025 - 0.00038
N-cyclopropyl-5-(2,3-dihydro-4H-1,4-benzothiazin-4-yl)thiophene-2-carboxamide
0.000077 - 0.00021
N-[3-fluoro-4-(trifluoromethyl)phenyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
0.00076
trifluoromethyl 6-(6-imino-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-9-yl)-1H-indole-3-carboxylate
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00121
[4-(6-imino-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-9-yl)phenyl](4-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)methanone
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.0025
[[3-(3-methylbut-2-en-1-yl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]oxy]acetonitrile
Schistosoma mansoni
pH 8.2, 25°C
-
0.000117
Homo sapiens
-
-
0.0925
(2Z)-2-cyano-3-cyclopropyl-3-hydroxy-N-[4-(trifluoromethyl)phenyl]prop-2-enamide
Plasmodium falciparum
-
-
0.00018
Homo sapiens
-
-
0.004
(2Z)-2-cyano-N-(2',3-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamide
Plasmodium falciparum
-
-
0.000022
Homo sapiens
-
-
0.165
(2Z)-2-cyano-N-(2,2'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamide
Plasmodium falciparum
-
-
0.00019
Homo sapiens
-
-
0.2366
(2Z)-2-cyano-N-(2,3'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamide
Plasmodium falciparum
-
-
0.00013
Homo sapiens
-
-
0.182
(2Z)-2-cyano-N-(3'-ethoxybiphenyl-4-yl)-3-hydroxybut-2-enamide
Plasmodium falciparum
-
-
0.00013
Homo sapiens
-
-
0.0474
(2Z)-N-(2'-chlorobiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide
Plasmodium falciparum
-
-
0.0002
Homo sapiens
-
-
0.0086
(2Z)-N-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide
Plasmodium falciparum
-
-
0.00017
Homo sapiens
-
-
0.0062
(2Z)-N-[2'-chloro-3-(trifluoromethyl)biphenyl-4-yl]-2-cyano-3-hydroxybut-2-enamide
Plasmodium falciparum
-
-
0.00023
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.11
1-(2-methoxyphenyl)-3-naphthalen-1-ylurea
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000554
Toxoplasma gondii
-
wild type enzyme, at pH 8.0 and 25°C
0.001635
1-hydroxy-2-dodecyl-4(1)quinolone
Toxoplasma gondii
-
mutant enzyme N302S, at pH 8.0 and 25°C
0.007
2-(1,1-difluoroethyl)-5-methyl-N-[4-(pentafluoro-lambda6-sulfanyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Homo sapiens
pH 8.2, 25°C
-
0.021
2-(1,1-difluoroethyl)-5-methyl-N-[4-(pentafluoro-lambda6-sulfanyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Schistosoma mansoni
pH 8.2, 25°C
-
0.000123
Homo sapiens
pH 8.2, 25°C
-
0.00019
2-(2,3-dichloroanilino)-3-hydroxynaphthalene-1,4-dione
Schistosoma mansoni
pH 8.2, 25°C
-
0.0099
Schistosoma mansoni
pH 8.2, 25°C
-
0.01
2-(2,6-dimethylanilino)-3-hydroxynaphthalene-1,4-dione
Homo sapiens
pH 8.2, 25°C
-
0.000078
Schistosoma mansoni
pH 8.2, 25°C
-
0.000808
2-(2-chloroanilino)-3-hydroxynaphthalene-1,4-dione
Homo sapiens
pH 8.2, 25°C
-
0.000129
Schistosoma mansoni
pH 8.2, 25°C
-
0.000911
2-(3-chloroanilino)-3-hydroxynaphthalene-1,4-dione
Homo sapiens
pH 8.2, 25°C
-
0.00801
Homo sapiens
pH 8.0, 22°C
-
0.2
2-(4-(pyridazin-3-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000185
Schistosoma mansoni
pH 8.2, 25°C
-
0.000541
2-(4-chloroanilino)-3-hydroxynaphthalene-1,4-dione
Homo sapiens
pH 8.2, 25°C
-
0.00033
Homo sapiens
pH 8.2, 25°C
-
0.001
2-(4-fluoroanilino)-3-hydroxynaphthalene-1,4-dione
Schistosoma mansoni
pH 8.2, 25°C
-
0.00044
Plasmodium falciparum
IC50: 0.00044 mM
0.491
2-cyano-3-(9-ethyl-9H-carbazol-3-ylamino)acrylic acid ethyl ester
Homo sapiens
-
IC50: 0.491 mM
0.000023
Schistosoma mansoni
pH 8.2, 25°C
-
0.000711
Schistosoma mansoni
pH 8.2, 25°C
-
0.0068
2-hydroxy-3-(4-phenylpiperazin-1-yl)naphthalene-1,4-dione
Homo sapiens
pH 8.2, 25°C
-
0.000108
Homo sapiens
pH 8.2, 25°C
-
0.000111
2-hydroxy-3-[3-(trifluoromethyl)anilino]naphthalene-1,4-dione
Schistosoma mansoni
pH 8.2, 25°C
-
0.00105
Homo sapiens
pH 8.2, 25°C
-
0.0021
2-[(2,3-dihydro-1,4-benzodioxin-6-yl)amino]-3-hydroxynaphthalene-1,4-dione
Schistosoma mansoni
pH 8.2, 25°C
-
0.000013
Homo sapiens
or above, pH not specified in the publication, temperature not specified in the publication
0.1
2-[(2,5-dichlorophenyl)sulfanyl]-5-ethyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol
Plasmodium falciparum
-
or above, pH not specified in the publication, temperature not specified in the publication
0.000051
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.011
2-[(2,5-dichlorophenyl)sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.0036
Homo sapiens
pH 8.2, 25°C
-
0.0055
2-[(2H-1,3-benzodioxol-5-yl)amino]-3-hydroxynaphthalene-1,4-dione
Schistosoma mansoni
pH 8.2, 25°C
-
0.0019
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.0065
2-[(3,4-dichlorophenyl)sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.001
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.039
2-[(4-chlorophenyl)sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.00093
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.03
2-[(E)-2-(2-methylphenyl)ethenyl]quinolin-4-ol
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00044
Schistosoma mansoni
pH 8.2, 25°C
-
0.0018
2-[4-(2,3-dichlorophenyl)piperazin-1-yl]-3-hydroxynaphthalene-1,4-dione
Homo sapiens
pH 8.2, 25°C
-
0.00028
Schistosoma mansoni
pH 8.2, 25°C
-
0.0046
2-[4-(4-chlorophenyl)piperazin-1-yl]-3-hydroxynaphthalene-1,4-dione
Homo sapiens
pH 8.2, 25°C
-
0.0079
Homo sapiens
pH 8.2, 25°C
-
0.0314
3-(3-methylbut-2-en-1-yl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl 4-methylbenzene-1-sulfonate
Schistosoma mansoni
pH 8.2, 25°C
-
0.00034
4-pentyl-1,3,4,10-tetrahydroacridin-9(2H)-one
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.03
4-pentyl-1,3,4,10-tetrahydroacridin-9(2H)-one
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00047
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0007
5-(1H-benzimidazol-1-yl)-N-propylthiophene-2-carboxamide
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.00046
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.00071
5-(1H-indol-1-yl)-N-propylthiophene-2-carboxamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00017
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.00063
5-(2-methyl-1H-benzimidazol-1-yl)-N-propylthiophene-2-carboxamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000042
Plasmodium falciparum
pH 8.0
0.000042
5-(2-methyl-1H-indol-1-yl)-N-propylthiophene-2-carboxamide
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.00006
5-(2-methyl-1H-indol-1-yl)-N-propylthiophene-2-carboxamide
Plasmodium berghei
-
pH 8.0
0.03
5-(2-methyl-1H-indol-1-yl)-N-propylthiophene-2-carboxamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.01
Homo sapiens
-
above, pH not specified in the publication, temperature not specified in the publication
0.03
5-(4-methylpiperazin-1-yl)-N-propylthiophene-2-carboxamide
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.01
Homo sapiens
-
above, pH not specified in the publication, temperature not specified in the publication
0.03
5-(piperidin-1-yl)-N-propylthiophene-2-carboxamide
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.000047
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.0013
5-methyl-N-(naphthalen-2-yl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Plasmodium falciparum
pH 8.0, 20°C, mutant F227A
0.0013
5-methyl-N-(naphthalen-2-yl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Plasmodium falciparum
pH 8.0, 20°C, mutant H185A
0.0021
5-methyl-N-(naphthalen-2-yl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Plasmodium falciparum
pH 8.0, 20°C, mutant F188A
0.0021
5-methyl-N-(naphthalen-2-yl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Plasmodium falciparum
pH 8.0, 20°C, mutant R265A
0.2
5-methyl-N-(naphthalen-2-yl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00028
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.00029
5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0014
5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Plasmodium falciparum
pH 8.0, 20°C, mutant F188A
0.0063
5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Plasmodium falciparum
pH 8.0, 20°C, mutant F227A
0.023
5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Plasmodium falciparum
pH 8.0, 20°C, mutant R265A
0.025
5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Plasmodium falciparum
pH 8.0, 20°C, mutant H185A
0.00016
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.03
diethyl [(dibenzo[b,d]thiophen-2-ylamino)methylidene]propanedioate
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00004
Plasmodium vivax
-
pH 8.0
0.00006
ethyl 4-(4-ethoxybenzyl)-3,5-dimethyl-1H-pyrrole-2-carboxylate
Plasmodium berghei
-
pH 8.0
0.000083
ethyl 4-(4-ethoxybenzyl)-3,5-dimethyl-1H-pyrrole-2-carboxylate
Plasmodium falciparum
pH 8.0
0.000083
ethyl 4-(4-ethoxybenzyl)-3,5-dimethyl-1H-pyrrole-2-carboxylate
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.03
ethyl 4-(4-ethoxybenzyl)-3,5-dimethyl-1H-pyrrole-2-carboxylate
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000014
Plasmodium berghei
-
pH 8.0, temperature not specified in the publication
0.000022
Genz-667348
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
0.000012
Plasmodium berghei
-
pH 8.0, temperature not specified in the publication
0.000044
Genz-668857
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
0.00004
Genz-669178
Plasmodium berghei
-
pH 8.0, temperature not specified in the publication
0.00005
Genz-669178
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
0.00005
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.05
N-(2,4-dichlorophenyl)naphthalene-2-carboxamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.049
Plasmodium falciparum
wild-type, pH 8.0, 25°C
0.087
N-(3,5-dichloro-phenyl)-2-methyl-3-nitro-benzamide
Plasmodium falciparum
mutant L531A, pH 8.0, 25°C
0.1
N-(3,5-dichloro-phenyl)-2-methyl-3-nitro-benzamide
Plasmodium falciparum
mutant R265A, pH 8.0, 25°C
1.9
N-(3,5-dichloro-phenyl)-2-methyl-3-nitro-benzamide
Plasmodium falciparum
mutant F188A, pH 8.0, 25°C
2.9
N-(3,5-dichloro-phenyl)-2-methyl-3-nitro-benzamide
Plasmodium falciparum
mutant H185A, pH 8.0, 25°C
12
N-(3,5-dichloro-phenyl)-2-methyl-3-nitro-benzamide
Plasmodium falciparum
mutant F227A, pH 8.0, 25°C
0.000016
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.2
N-(3,5-dichlorophenyl)-2-methyl-3-nitrobenzamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00068
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0014
N-(3-chlorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.0005
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0092
N-(3-fluorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.000056
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.0007
N-(anthracen-2-yl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00021
Plasmodium falciparum
pH 8.0, 20°C, mutant F188A
0.0013
N-anthracen-2-yl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Plasmodium falciparum
pH 8.0, 20°C, mutant H185A
0.0024
N-anthracen-2-yl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Plasmodium falciparum
pH 8.0, 20°C, mutant R265A
0.0044
N-anthracen-2-yl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Plasmodium falciparum
pH 8.0, 20°C, mutant F227A
0.00025
Plasmodium falciparum
pH 8.0
0.00028
N-cyclopropyl-5-(2,3-dihydro-4H-1,4-benzothiazin-4-yl)thiophene-2-carboxamide
Plasmodium vivax
-
pH 8.0
0.00038
N-cyclopropyl-5-(2,3-dihydro-4H-1,4-benzothiazin-4-yl)thiophene-2-carboxamide
Plasmodium berghei
-
pH 8.0
0.01
Homo sapiens
-
above, pH not specified in the publication, temperature not specified in the publication
0.03
N-propyl-5-(1H-pyrazol-1-yl)thiophene-2-carboxamide
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.000077
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.00021
N-[3-fluoro-4-(trifluoromethyl)phenyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
additional information
[2-fluoro-2',5'-dimethyl-4'-[6-(3-methyl-2-butenyloxy)pyridin-3-yl]biphenyl-4-yl]-(3-methyl-2-butenyl)amine
Homo sapiens
-
IC50 value 23 ng per ml
additional information
[2-fluoro-2',5'-dimethyl-4'-[6-(3-methyl-2-butenyloxy)pyridin-3-yl]biphenyl-4-yl]-(3-methyl-2-butenyl)amine
Mus musculus
-
IC50 value 32 ng per ml