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1.3.3.6: acyl-CoA oxidase

This is an abbreviated version!
For detailed information about acyl-CoA oxidase, go to the full flat file.

Word Map on EC 1.3.3.6

Reaction

acyl-CoA
+
O2
=
trans-2,3-dehydroacyl-CoA
 +
H2O2

Synonyms

3alpha,7alpha, 12alpha-trihydroxy-5beta-cholestanoyl-CoA oxidase, ACO, ACO I, ACO-A1, ACO-I, ACO-II, ACOX, ACOX-1, ACOX-1.1, ACOX-1.2, ACOX-1.3, ACOX-2, ACOX-3, ACOX1, ACOX1-3I, ACOX1a, ACOX1b, ACOX1–3II, ACOX2, ACOX3, ACX, ACX1, ACX1.2, ACX2, ACX3, ACX4, ACX5, acyl coenzyme A oxidase, acyl-CoA dehydrogenase, Acyl-CoA oxidase, acyl-CoA oxidase 1, acyl-CoA oxidase 1a, acyl-CoA oxidase 1b, acyl-CoA oxidase 2, acyl-CoA oxidase 4, acyl-CoA oxidase I, acyl-CoA oxidase-1, acyl-CoA oxidase-II, acyl-CoA-oxidase, acyl-coenzyme A oxidase, acyl-coenzyme A oxidase 1, acyl-coenzyme A oxidase 4, acyl-coenzyme A: oxygen oxidoreductase, AOX, AOX1, AOX2, Aox2p, AOX3, Aox3p, AOX4, aoxA, Aoxp, AtACX1, AtACX2, AtACX3, AtSACX, BRCACox, CrACX2, Cre05.g232002, fatty acyl-CoA oxidase, fatty acyl-coenzyme A oxidase, long chain acyl-CoA oxidase, long chain fatty acyl coenzyme A oxidase, long chain fatty acyl-CoA oxidase, long-chain-specific acyl-CoA oxidase 1, MCAD Y375K, MCOX, oxidase, acyl-coenzyme A, palmitoyl-CoA oxidase, peroxisomal acyl-coenzyme A oxidase, Peroxisomal fatty acyl-CoA oxidase, POX1, Pox1p, POX4, PpACX1, Pristanoyl-CoA oxidase, SCOX, short chain-specific acyl-CoA oxidase, short-chain acyl-CoA oxidase, straight chain acyl-CoA oxidase, straight-chain acyl-coenzyme A oxidase, THCA-CoA oxidase, THCCox, Trihydroxycoprostanoyl-CoA oxidase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.3 With oxygen as acceptor
                1.3.3.6 acyl-CoA oxidase

Activating Compound

Activating Compound on EC 1.3.3.6 - acyl-CoA oxidase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3-Amino-1,2,4-triazole
-
enhances acyl-CoA oxidation, avoids H2O2 consumption by endogenous catalase
alpha-linolenic acid-rich perilla oil
-
stimulates
-
bovine serum albumin
-
slightly increases ACO activity, maximum value of ACO acitvity at 0.036 mM
-
casein
stimulates
CoA
co-treatment with ACX1 and CoA significantly promoted the biosynthesis of gamma-decalactone compared to the control
di-(2-ethylhexyl)phthalate
-
-
fish oil
-
markedly increases enzyme activity
-
growth hormone
-
increases the mRNA of acyl CoA oxidase, directly induces the expression of AOX in adipocytes through STAT5A binding to the -1841 to -1825 site within the AOX promoter
-
jasmonate
upregulates expression of ACX1, starts 4 h after treatment and remains elevated until 24 h
leptin
-
3fold increased activity at 100 ng/ml acute treatment
-
MnCl2
-
slightly activating
n-Alkane
-
increases ACO activity progressively with palmitoyl-CoA by 23%, with stearoyl-CoA by 42%, with behenoyl-CoA by 47% and with lignoceroyl-CoA by 75%
-
perfluorooctane sulfonate
perilla oil
-
elevates AOX activity in a 4-day fedding, the effect is gradually decreased in a 4-week feeding
-
Peroxidase
-
stimulates, maximum value of ACO acitvity at 0.24 mg
-
phenol
-
low concentration, magnitude of activation depends on the nature of the acyl-CoA substrate
prolactin
-
increases the mRNA of acyl CoA oxidase
-
propionate
-
increase in propionate concentration lead to increase of enzyme amount
tetracosane
-
stimulates, highest activity with lignoceroyl-CoA as substrate
Triton X-100
-
stimulates, maximum value of ACO acitvity at 0.08%
additional information
-