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1.3.3.4: protoporphyrinogen oxidase

This is an abbreviated version!
For detailed information about protoporphyrinogen oxidase, go to the full flat file.

Word Map on EC 1.3.3.4

Reaction

protoporphyrinogen IX
+ 3 O2 =
protoporphyrin IX
 + 3 H2O2

Synonyms

HemG, HemG-type PPO, HemG-type protoporphyrinogen IX oxidase, hemY, hPPO, H_N10, H_N40, H_N90, LMJF_06_1280, mtPPO, MxPPOX, MxProtox, PPO, PPO1, ppo1-1, PPO2, PPOX, PPOX I, PPX1, PPX2, protein YfeX, protogen oxidase, protoporphyrinogen IX oxidase, protoporphyrinogen IX oxidase 1, protoporphyrinogen oxidase, protoporphyrinogen oxidase IX, protoporphyrinogenase, protox, Protox enzyme, R-PPO, Rs-slr1790 protein, S-PPO, Salk_143057, YfeX

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.3 With oxygen as acceptor
                1.3.3.4 protoporphyrinogen oxidase

IC50 Value

IC50 Value on EC 1.3.3.4 - protoporphyrinogen oxidase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.03963
1-nitro-4-phenoxybenzene
Nicotiana tabacum
pH 7.4, temperature not specified in the publication
0.000022
2-chloro-4-[4-[chloro(difluoro)methyl]-3-[(prop-2-yn-1-yl)oxy]phenyl]furan-3-carboxamide
Nicotiana tabacum
pH 7.4, temperature not specified in the publication
0.00558
2-chloro-4-[4-[chloro(difluoro)methyl]phenyl]furan-3-carbonyl chloride
Nicotiana tabacum
pH 7.4, temperature not specified in the publication
0.000061
2-chloro-4-[4-[chloro(difluoro)methyl]phenyl]furan-3-carboxamide
Nicotiana tabacum
pH 7.4, temperature not specified in the publication
0.000014
2-[5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrophenoxy]furan
Nicotiana tabacum
pH 7.4, temperature not specified in the publication
0.02616
5-[2-chloro-5-(trifluoromethyl)phenoxy]-2-nitrobenzoic acid
Nicotiana tabacum
pH 7.4, temperature not specified in the publication
0.000019 - 0.617
acifluorfen
0.1
Atrazine
Homo sapiens
-
IC50 above 0.1 mM, at pH 7.2 and 37°C
0.000032
benzofluorfen
Nicotiana tabacum
pH 7.4, temperature not specified in the publication
0.00015
butafenacil
Homo sapiens
-
at pH 7.2 and 37°C
0.00042
chlornitrofen
Homo sapiens
-
at pH 7.2 and 37°C
0.1
chlortoluron, ethyl (2,4-dichloro-5-[(E)-[(2-hydroxynaphthalen-1-yl)methylidene]amino]phenoxy)acetate, ethyl (2,4-dichloro-5-[[(Z)-[4-oxo-2-[(propan-2-yl)oxy]-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]phenoxy)acetate, ethyl (2,4-dichloro-5-[[(Z)-[6-fluoro-4-oxo-2-[(propan-2-yl)oxy]-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]phenoxy)acetate, ethyl (2,4-dichloro-5-[[(Z)-[6-nitro-4-oxo-2-[(propan-2-yl)oxy]-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]phenoxy)acetate
Homo sapiens
-
IC50 above 0.1 mM, at pH 7.2 and 37°C
-
0.000057 - 0.02279
ethyl 2-[5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrophenoxy]propanoate
0.000199
ethyl N-(2-bromo-4-[4-[chloro(difluoro)methyl]phenyl]furan-3-carbonyl)alaninate
Nicotiana tabacum
pH 7.4, temperature not specified in the publication
0.000357
ethyl N-(2-chloro-4-[4-[chloro(difluoro)methyl]phenyl]furan-3-carbonyl)alaninate
Nicotiana tabacum
pH 7.4, temperature not specified in the publication
0.1
ethyl [2,4-dichloro-5-[(E)-(2,5-dihydroxybenzylidene)amino]phenoxy]acetate, ethyl [2,4-dichloro-5-[(E)-(2-hydroxy-3-methoxybenzylidene)amino]phenoxy]acetate, ethyl [2,4-dichloro-5-[(E)-(2-hydroxy-4-methylbenzylidene)amino]phenoxy]acetate, ethyl [2,4-dichloro-5-[(E)-(5-chloro-2-hydroxybenzylidene)amino]phenoxy]acetate
Homo sapiens
-
IC50 above 0.1 mM, at pH 7.2 and 37°C
-
0.000147
fluorodifen
Nicotiana tabacum
pH 7.4, temperature not specified in the publication
0.000031
fomesafen
Nicotiana tabacum
pH 7.4, temperature not specified in the publication
0.00011
formesafen
Homo sapiens
-
at pH 7.2 and 37°C
-
0.000062 - 0.00033
lactofen
0.000053
methyl 2-chloro-5-[2-chloro-4-(trifluoromethyl)phenoxy]benzoate
Nicotiana tabacum
pH 7.4, temperature not specified in the publication
0.00386
methyl 3-[2-chloro-5-(3,5-dimethyl-2,6-dioxo-4-sulfanylidene-1,3,5-triazinan-1-yl)-4-fluorophenyl]-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxylate
Homo sapiens
-
at pH 7.2 and 37°C
-
0.000599
methyl 4-[4-[chloro(difluoro)methyl]phenyl]-2-(trifluoromethyl)furan-3-carboxylate
Nicotiana tabacum
pH 7.4, temperature not specified in the publication
0.01254
methyl 5-[2-chloro-4-(trifluoromethyl)benzene-1-sulfinyl]-2-nitrobenzoate
Nicotiana tabacum
pH 7.4, temperature not specified in the publication
0.0474
methyl 5-[2-chloro-4-(trifluoromethyl)benzene-1-sulfonyl]-2-nitrobenzoate
Nicotiana tabacum
pH 7.4, temperature not specified in the publication
0.00222
methyl 5-[2-chloro-5-(trifluoromethyl)phenoxy]-2-nitrobenzoate
Nicotiana tabacum
pH 7.4, temperature not specified in the publication
0.000048
methyl 5-[[2-chloro-4-(trifluoromethyl)phenyl]sulfanyl]-2-nitrobenzoate
Nicotiana tabacum
pH 7.4, temperature not specified in the publication
0.000014
methyl [[(E)-(1-[5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrophenyl]ethylidene)amino]oxy]acetate
Nicotiana tabacum
pH 7.4, temperature not specified in the publication
0.000015 - 0.000027
N2-(5-[[4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]oxy]-2-nitrophenyl)-N-methylleucinamide
0.000012 - 0.000027
N2-(5-[[4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]oxy]-2-nitrophenyl)-N-methylnorleucinamide
0.000406
nitrofen
Nicotiana tabacum
pH 7.4, temperature not specified in the publication
0.00007
nitrofluorfen
Nicotiana tabacum
pH 7.4, temperature not specified in the publication
0.00085
oxadiargyl
Homo sapiens
-
at pH 7.2 and 37°C
0.00192
oxadiazon
Homo sapiens
-
at pH 7.2 and 37°C
0.000054 - 0.00013
oxyfluorfen
0.0000373 - 0.00025
saflufenacil
0.0000293
tiafenacil
Arabidopsis thaliana
pH and temperature not specified in the publication
-
0.00001
[[(E)-(1-[5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrophenyl]ethylidene)amino]oxy]acetic acid
Nicotiana tabacum
pH 7.4, temperature not specified in the publication
additional information
additional information
-