Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.3.3.3: coproporphyrinogen oxidase

This is an abbreviated version!
For detailed information about coproporphyrinogen oxidase, go to the full flat file.

Word Map on EC 1.3.3.3

Reaction

Coproporphyrinogen III
+
O2
+ 2 H+ =
protoporphyrinogen-IX
+ 2 CO2 + 2 H2O

Synonyms

copro'gen oxidase, Coprogen oxidase, coproporphyinogen oxidase, coproporphyrinogen III oxidase, coproporphyrinogen oxidase, coproporphyrinogen-III oxidase, coproporphyrinogenase, COX, CPgen oxidase, CPGox, CPO, CPO III oxidase, CPOX, CPOX4, CPX, CPX1, CPX2, HEM13, Hem13p, HemF, HEMN1, KlHEM13, LIN2, LMM2, O2-dependent coproporphyrinogen III oxidase, oxygen-dependent coproporphyrinogen III oxidase, oxygen-dependent coproporphyrinogen-III oxidase, Sll1185

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.3 With oxygen as acceptor
                1.3.3.3 coproporphyrinogen oxidase

Reference

Reference on EC 1.3.3.3 - coproporphyrinogen oxidase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sorianello, E.M.; Mazzetti, M.B.
Function and structure of rat hepatic coproporphyrinogen oxidase
Comp. Biochem. Physiol. B
127
155-164
2000
Rattus sp.
Manually annotated by BRENDA team
Jones, M.A.; He, J.; Lash, T.D.
Kinetic studies of novel di- and tri-propionate substrates for the chicken red blood cell enzyme coproporphyrinogen oxidase
J. Biochem.
131
201-205
2002
Gallus gallus
Manually annotated by BRENDA team
Gross, U.; Puy, H.; Kuhnel, U.; Meissauer, U.; Deybach, J.C.; Jacob, K.; Martasek, P.; Nordmann, Y.; Doss, M.O.
Molecular, immunological, enzymatic and biochemical studies of coproporphyrinogen oxidase deficiency in a family with hereditary coproporphyria
Cell. Mol. Biol.
48
49-55
2002
Homo sapiens
Manually annotated by BRENDA team
Mock, H.P; Heller, W.; Molina, A.; Neubohn, B.; Sandermann, H.; Grimm, B.
Expression of uroporphyrinogen decarboxylase or coproporphyrinogen oxidase antisense RNA in tobacco induces pathogen defense responses conferring increased resistance to tobacco mosaic virus
J. Biol. Chem.
274
4231-4238
1999
Nicotiana tabacum
Manually annotated by BRENDA team
Narita, S.; Taketani, S.; Inokuchi, H.
Oxidation of protoporphyrinogen IX in Escherichia coli is mediated by the aerobic coproporphyrinogen oxidase
Mol. Gen. Genet.
261
1012-1020
1999
Escherichia coli
Manually annotated by BRENDA team
Martasek, P.; Camadro, J.M.; Raman, R.S.; Lecomte, M.C.; Le Caer, J.P.; Demeler, B.; Grandchamp, B.; Labbe, P.
Human coproporphyrinogen oxidase. Biochemical characterization of recombinant normal and R231W mutated enzymes expressed in E. coli as soluble, catalytically active homodimers
Cell. Mol. Biol.
43
47-58
1997
Homo sapiens
Manually annotated by BRENDA team
Yoshinaga, T.
Purification and properties of coproporphyrinogen III oxidase from bovine liver
Methods Enzymol.
281
355-367
1997
Bos taurus, Mus musculus
Manually annotated by BRENDA team
Jones, M.A.; Hamilton, M.L.; Lash, T.D.
Effect of covalent modification on coproporphyrinogen oxidase from chicken red blood cells
Prep. Biochem. Biotechnol.
27
47-57
1997
Gallus gallus
Manually annotated by BRENDA team
Medlock, A.E.; Dailey, H.A.
Human coproporphyrinogen oxidase is not a metalloprotein
J. Biol. Chem.
271
32507-32510
1996
Homo sapiens
Manually annotated by BRENDA team
Kohno, H.; Furukawa, T.; Yoshinaga, T.; Tokunaga, R.; Taketani, S.
Coproporhyrinogen oxidase. Purification, molecular cloning, and induction of mRNA during erythroid differentiation
J. Biol. Chem.
268
21359-21363
1993
Bos taurus, Mus musculus
Manually annotated by BRENDA team
Kohno, H.; Furukawa, T.; Tokunaga, R.; Taketani, S.; Yoshinaga, T.
Mouse coprophorphyrinogen oxidase is a copper-containing enzyme: expression in E. coli and site-directed mutagenesis
Biochim. Biophys. Acta
1292
156-162
1996
Mus musculus
Manually annotated by BRENDA team
Hill, K.L.; Merchant, S.
Coordinate expression of coproporphyrinogen oxidase and cytochrome c6 in the green alga Chlamydomonas reinhardtii in response to changes in copper availability
EMBO J.
14
857-865
1995
Chlamydomonas reinhardtii
Manually annotated by BRENDA team
Troup, B.; Hungerer, C.; Jahn, D.
Cloning and characterization of the Escherichia coli hemN gene encoding the oxygen-independent coproporphyrinogen III oxidase
J. Bacteriol.
177
3326-3331
1995
Escherichia coli
Manually annotated by BRENDA team
Bogard, M.; Camadro, J.M.; Labbe, P.
Purification and properties of mouse liver coproporphyrinogen oxidase
Eur. J. Biochem.
181
417-421
1989
Mus musculus
Manually annotated by BRENDA team
Zagorec, M.; Buhler, J.M.; Treich, I.; Keng, T.; Guarente, L.; Labbe-Bois, R.
Isolation, sequence, and regulation by oxygen of the yeast hem13 gene coding for coproporphyrinogen oxidase
J. Biol. Chem.
263
9718-9724
1988
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Al-Hazimi, H.M.G.; Jackson, A.H.; Knight, D.W.; Lash, T.D.
Synthetic and biosynthetic studies of porphyrins. Part 7. The Action of coproporphyrinogen oxidase on coproporphyrinogen-IV: Syntheses of protoporphyrin-XII, mesoporphyrin XIII, and related tricarboxylic porphyrins
J. Chem. Soc. Perkin Trans. I
1987
265-276
1987
Gallus gallus
-
Manually annotated by BRENDA team
Li, F.; Lim, C.K.; Peters, T.J.
A high-performance-liquid-chromatographic method for the assay of coproporphyrinogen oxidase activity in rat liver
Biochem. J.
239
481-484
1986
Rattus sp.
Manually annotated by BRENDA team
Camadro, J.M.; Chambon, H.; Jolles, J.; Labbe, P.
Purification and properties of coproporphyrinogen oxidase from yeast Saccharomyces cerevisiae
Eur. J. Biochem.
156
579-587
1986
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Robinson, J.A.; McDonald, E.; Battersby, A.R.
Biosynthesis of porphyrins and related macrocycles. Part 25. Synthesis of analogues of coproporphyrinogen-III and studies of their interaction with coproporphyrinogen-III oxidase from Euglena gracilis
J. Chem. Soc. Perkin Trans. I
1985
1699-1709
1985
Euglena gracilis
-
Manually annotated by BRENDA team
Seehra, J.S.; Jordan, P.M.; Akhtar, M.
Anaerobic and aerobic coproporphyrinogen III oxidases of Rhodopseudomonas spheroids. Mechanism and stereochemistry of vinyl group formation
Biochem. J.
209
709-718
1983
Cereibacter sphaeroides
Manually annotated by BRENDA team
Keithly, J.H.; Nadler, K.D.
Protoporphyrin formation in Rhizobium japonicum
J. Bacteriol.
154
838-845
1983
Bradyrhizobium japonicum
Manually annotated by BRENDA team
Yoshinaga, T.; Sano, S.
Coproporphyrinogen oxidase. I. Purification, properties, and activation by phospholipids
J. Biol. Chem.
255
4722-4726
1980
Bos taurus
Manually annotated by BRENDA team
Yoshinaga, T.; Sano, S.
Coproporphyrinogen oxidase. II. Reaction mechanism and role of tyrosine residues on the activity
J. Biol. Chem.
255
4727-4731
1980
Bos taurus
Manually annotated by BRENDA team
Battersby, A.R.; Hamilton, A.D.; McDonald, E.; Mombelli, L.; Wong, Q.H.
Biosynthesis of porphyrins and related macrocycles. Part 13. Structure of the protopophyrin isomer derived from coproporphyrinogen IV by the action of beef-liver coproporphyrinogenase: Synthesis of protoporphyrin XIII
J. Chem. Soc. Perkin Trans. I
1980
1283-1289
1980
Bos taurus
-
Manually annotated by BRENDA team
Kardish, R.M.; Woods, J.S.
Measurement of heme biosynthetic enzymes in mammalian tissues. II. Coproporphyrinogen oxidase
J. Appl. Biochem.
2
168-174
1980
Rattus sp.
-
Manually annotated by BRENDA team
Grandchamp, B.; Phung, N.; Nordmann, Y.
The mitochondrial localization of coproporphyrinogen III oxidase
Biochem. J.
176
97-102
1978
Rattus sp.
Manually annotated by BRENDA team
Elder, G.H.; Evans, J.O.
Evidence that the coproporphyrinogen oxidase activity of rat liver is situated in the intermembrane space of mitochondria
Biochem. J.
172
345-347
1978
Rattus sp.
Manually annotated by BRENDA team
Elder, G.H.; Evans, J.O.; Jackson, J.R.; Jackson, A.H.
Factors determining the sequence of oxidative decarboxylation of the 2- and 4-propionate substituents of coproporphyrinogen III by coproporphyrinogen oxidase in rat liver
Biochem. J.
169
215-223
1978
Rattus sp.
Manually annotated by BRENDA team
Elder, G.H.; Evans, J.O.
A radiochemical method for the measurement of coproporphyrinogen oxidase and the utilization of substrates other than coproporphyrinogen III by the enzyme from rat liver
Biochem. J.
169
205-214
1978
Rattus sp.
Manually annotated by BRENDA team
Jackson, A.H.; Jones, D.M.
Mesoporphyrinogen-VI: a substrate for coproporphyrinogen oxidase
J. Chem. Soc. Chem. Commun.
1976
322-323
1976
Gallus gallus
-
Manually annotated by BRENDA team
Al-Hazimi, H.M.G.; Jackson, A.H.; Ryder, D.J.
Specificity of coproporphyrinogen oxidase: Conversion of coproporphyrinogen-IV into protoporphyrin-XIII
J. Chem. Soc. Chem. Commun.
1976
188-189
1976
Gallus gallus
-
Manually annotated by BRENDA team
Poulson, R.; Polglase, W.J.
Aerobic and anaerobic coproporphyrinogenase activities in extracts from Saccharomyces cerevisiae. Purification and characterization
J. Biol. Chem.
249
6367-6371
1974
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Tait, G.H.
Coproporphyrinogenase activities in extracts of Rhodopseudomonas spheroids
Biochem. J.
118
28P-29P
1976
Cereibacter sphaeroides
Manually annotated by BRENDA team
Tait, G.H.
Coproporphyrinogenase activities in extracts of Rhodopseudomonas spheroids and Chromatium strain D
Biochem. J.
128
1159-1169
1972
Chromatium sp., Cereibacter sphaeroides, Chromatium sp. D
Manually annotated by BRENDA team
Mori, M.; Sano, S.
Studies on the formation of protoporphyrin IX by anaerobic bacteria
Biochim. Biophys. Acta
264
252-262
1972
Chromatium sp., no activity in Desulfovibrio vulgaris, Chromatium sp. D
-
Manually annotated by BRENDA team
Hsu, W.P.; Miller, G.W.
Coproporphyrinogenase in tobacco (Nicotiana tabacum L.)
Biochem. J.
117
215-220
1970
Nicotiana tabacum
Manually annotated by BRENDA team
Miyake, S.; Sugimura, T.
Coproporphyrinogenase in a respiration-deficient mutant of yeast lacking all cytochromes and accumulating coproporphyrin
J. Bacteriol.
96
1997-2003
1968
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Battle, A.M.del C.; Benson, A.; Rimington, C.
Purification and properties of coproporphyrinogenase
Biochem. J.
97
731-740
1965
Rattus sp.
Manually annotated by BRENDA team
Lash, T.D.; Keck, A.S.; Mani, U.N.; Jones, M.A.
Unprecedented overmetabolism of a porphyrinogen substrate by coproporphyrinogen oxidase
Bioorg. Med. Chem. Lett.
12
1079-1082
2002
Gallus gallus
Manually annotated by BRENDA team
Lash, T.D.; Kaprak, T.A.; Shen, L.; Jones, M.A.
Metabolism of analogues of coproporphyrinogen-III with modified side chains: implications for binding at the active site of coproporphyrinogen oxidase
Bioorg. Med. Chem. Lett.
12
451-456
2002
Gallus gallus, Euglena gracilis
Manually annotated by BRENDA team
Jones, M.A.; Taneja, M.; Xu, Y.; Chung, W.; Stob, C.M.; Lash, T.D.
An effective chromatographic separation of chicken red blood cell coproporphyrinogen oxidase and uroporphyrinogen decarboxylase, two enzymes in heme biosynthesis
Bioorg. Med. Chem. Lett.
14
5559-5564
2004
Gallus gallus
Manually annotated by BRENDA team
Susa, S.; Daimon, M.; Ono, H.; Li, S.; Yoshida, T.; Kato, T.
Heme inhibits the mitochondrial import of coproporphyrinogen oxidase. Comments
Blood
100
4678-4679
2002
Homo sapiens
Manually annotated by BRENDA team
Macieira, S.; Martins, B.M.; Huber, R.
Oxygen-dependent coproporphyrinogen-III oxidase from Escherichia coli: one-step purification and biochemical characterisation
FEMS Microbiol. Lett.
226
31-37
2003
Escherichia coli (P36553), Escherichia coli
Manually annotated by BRENDA team
Breckau, D.; Mahlitz, E.; Sauerwald, A.; Layer, G.; Jahn, D.
Oxygen-dependent coproporphyrinogen III oxidase (HemF) from Escherichia coli is stimulated by manganese
J. Biol. Chem.
278
46625-46631
2003
Escherichia coli
Manually annotated by BRENDA team
Phillips, J.D.; Whitby, F.G.; Warby, C.A.; Labbe, P.; Yang, C.; Pflugrath, J.W.; Ferrara, J.D.; Robinson, H.; Kushner, J.P.; Hill, C.P.
Crystal structure of the oxygen-dependant coproporphyrinogen oxidase (Hem13p) of Saccharomyces cerevisiae
J. Biol. Chem.
279
38960-38968
2004
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Wiman, A.; Floderus, Y.; Harper, P.
Two novel mutations and coexistence of the 991C>T and the 1339C>T mutation on a single allele in the coproporphyrinogen oxidase gene in Swedish patients with hereditary coproporphyria
J. Hum. Genet.
47
407-412
2002
Homo sapiens
Manually annotated by BRENDA team
Santana, M.A.; Tan, F.C.; Smith, A.G.
Molecular characterization of coproporphyrinogen oxidase from Glycine max and Arabidopsis thaliana
Plant Physiol. Biochem.
40
289-298
2002
Glycine max, Lotus japonicus, Vigna radiata var. radiata, Arabidopsis thaliana (Q93Z96), Arabidopsis thaliana (Q9LR75)
-
Manually annotated by BRENDA team
Stephenson, J.R.; Thomas, N.E.; Friesen, J.A.; Jones, M.A.
Use of crosslinking to assess subunit interaction of recombinant human coproporphyrinogen oxidase
Am. J. Biochem. Biotechnol.
1
103-106
2005
Homo sapiens
-
Manually annotated by BRENDA team
Layer, G.; Kervio, E.; Morlock, G.; Heinz, D.W.; Jahn, D.; Retey, J.; Schubert, W.D.
Structural and functional comparison of HemN to other radical SAM enzymes
Biol. Chem.
386
971-980
2005
Escherichia coli
Manually annotated by BRENDA team
Cooper, C.L.; Stob, C.M.; Jones, M.A.; Lash, T.D.
Metabolism of pentacarboxylate porphyrinogens by highly purified human coproporphyrinogen oxidase: further evidence for the existence of an abnormal pathway for heme biosynthesis
Bioorg. Med. Chem.
13
6244-6251
2005
Homo sapiens
Manually annotated by BRENDA team
Sinha, A.K.; Anand, S.; Ortel, B.J.; Chang, Y.; Mai, Z.; Hasan, T.; Maytin, E.V.
Methotrexate used in combination with aminolaevulinic acid for photodynamic killing of prostate cancer cells
Br. J. Cancer
95
485-495
2006
Homo sapiens
Manually annotated by BRENDA team
Akagi, R.; Inoue, R.; Muranaka, S.; Tahara, T.; Taketani, S.; Anderson, K.E.; Phillips, J.D.; Sassa, S.
Dual gene defects involving delta-aminolaevulinate dehydratase and coproporphyrinogen oxidase in a porphyria patient
Br. J. Haematol.
132
237-243
2006
Homo sapiens (P36551)
Manually annotated by BRENDA team
Blanco, M.; Becerra, M.; Gonzalez-Siso, M.I.; Cerdan, M.E.
Functional characterization of KlHEM13, a hypoxic gene of Kluyveromyces lactis
Can. J. Microbiol.
51
241-249
2005
Kluyveromyces lactis (Q70W35), Kluyveromyces lactis
Manually annotated by BRENDA team
Qian, F.; Zhen, F.; Ong, C.; Jin, S.W.; Meng Soo, H.; Stainier, D.Y.; Lin, S.; Peng, J.; Wen, Z.
Microarray analysis of zebrafish cloche mutant using amplified cDNA and identification of potential downstream target genes
Dev. Dyn.
233
1163-1172
2005
Danio rerio
Manually annotated by BRENDA team
Hanaoka, R.; Katayama, S.; Dawid, I.B.; Kawahara, A.
Characterization of the heme synthesis enzyme coproporphyrinogen oxidase (CPO) in zebrafish erythrogenesis
Genes Cells
11
293-303
2006
Danio rerio
Manually annotated by BRENDA team
Schmitt, C.; Gouya, L.; Malonova, E.; Lamoril, J.; Camadro, J.M.; Flamme, M.; Rose, C.; Lyoumi, S.; Da Silva, V.; Boileau, C.; Grandchamp, B.; Beaumont, C.; Deybach, J.C.; Puy, H.
Mutations in human CPO gene predict clinical expression of either hepatic hereditary coproporphyria or erythropoietic harderoporphyria
Hum. Mol. Genet.
14
3089-3098
2005
Homo sapiens
Manually annotated by BRENDA team
Zeilstra-Ryalls, J.H.; Schornberg, K.L.
Analysis of hemF gene function and expression in Rhodobacter sphaeroides 2.4.1
J. Bacteriol.
188
801-804
2006
Cereibacter sphaeroides
Manually annotated by BRENDA team
Vasanthaiah, H.K.; Ravishankar, K.V.; Shivashankara, K.S.; Anand, L.; Narayanaswamy, P.; Mukunda, G.; Prasad, T.G.
Cloning and characterization of differentially expressed genes of internal breakdown in mango fruit (Mangifera indica)
J. Plant Physiol.
163
671-679
2006
Mangifera indica
Manually annotated by BRENDA team
Cooper, C.L.; Lash, T.D.; Jones, M.A.
Kinetic evaluation of human cloned coproporphyrinogen oxidase using a ring isomer of the natural substrate
Med. Sci. Monit.
11
BR420-BR425
2005
Homo sapiens
Manually annotated by BRENDA team
Gitter, S.J.; Cooper, C.L.; Friesen, J.A.; Jones, M.A.
Investigation of the catalytic and structural roles of conserved histidines of human coproporphyrinogen oxidase using site-directed mutagenesis
Med. Sci. Monit.
13
BR1-BR10
2006
Homo sapiens (P36551), Homo sapiens
Manually annotated by BRENDA team
Echeverria, D.; Woods, J.S.; Heyer, N.J.; Rohlman, D.; Farin, F.M.; Li, T.; Garabedian, C.E.
The association between a genetic polymorphism of coproporphyrinogen oxidase, dental mercury exposure and neurobehavioral response in humans
Neurotoxicol. Teratol.
28
39-48
2006
Homo sapiens
Manually annotated by BRENDA team
Williams, P.; Hardeman, K.; Fowler, J.; Rivin, C.
Divergence of duplicated genes in maize: evolution of contrasting targeting information for enzymes in the porphyrin pathway
Plant J.
45
727-739
2006
Zea mays (Q2F7H7), Zea mays (Q2F7H8), Zea mays
Manually annotated by BRENDA team
Stephenson, J.R.; Stacey, J.A.; Morgenthaler, J.B.; Friesen, J.A.; Lash, T.D.; Jones, M.A.
Role of aspartate 400, arginine 262, and arginine 401 in the catalytic mechanism of human coproporphyrinogen oxidase
Protein Sci.
16
401-410
2007
Homo sapiens, Homo sapiens (P36551)
Manually annotated by BRENDA team
Heyer, N.J.; Bittner, A.C.; Echeverria, D.; Woods, J.S.
A cascade analysis of the interaction of mercury and coproporphyrinogen oxidase (CPOX) polymorphism on the heme biosynthetic pathway and porphyrin production
Toxicol. Lett.
161
159-166
2006
Homo sapiens
Manually annotated by BRENDA team
Wang, Y.; Gatti, P.; Sadilek, M.; Scott, C.R.; Turecek, F.; Gelb, M.H.
Direct assay of enzymes in heme biosynthesis for the detection of porphyrias by tandem mass spectrometry. Uroporphyrinogen decarboxylase and coproporphyrinogen III oxidase
Anal. Chem.
80
2599-2605
2008
Homo sapiens
Manually annotated by BRENDA team
Silva, P.J.; Ramos, M.J.
A comparative density-functional study of the reaction mechanism of the O2-dependent coproporphyrinogen III oxidase
Bioorg. Med. Chem.
16
2726-2733
2008
Homo sapiens, synthetic construct
Manually annotated by BRENDA team
Morgenthaler, J.B.; Barto, R.L.; Lash, T.D.; Jones, M.A.
Use of di- and tripropionate substrate analogs to probe the active site of human recombinant coproporphyrinogen oxidase
Med. Sci. Monit.
14
BR1-BR7
2008
Homo sapiens
Manually annotated by BRENDA team
Bjoerkman, L.; Vahter, M.
A cascade analysis of the interaction of mercury and coproporphyrinogen oxidase (CPOX) polymorphism on the heme biosynthetic pathway and porphyrin production by Heyer et al. [Toxicol. Lett. 161 (2006) 159-166]. Comment
Toxicol. Lett.
169
91-92
2007
Homo sapiens
Manually annotated by BRENDA team
Heyer, N.J.; Bittner, A.C.; Echeverria, D.; Woods, J.S.
A cascade analysis of the interaction of mercury and coproporphyrinogen oxidase (CPOX) polymorphism on the heme biosynthetic pathway and porphyrin production by Heyer et al. [Toxicol. Lett. 161 (2006) 159-166]. Reply
Toxicol. Lett.
169
93-94
2007
Homo sapiens
Manually annotated by BRENDA team
Aurizi, C.; Lupia Palmieri, G.; Barbieri, L.; Macri, A.; Sorge, F.; Usai, G.; Biolcati, G.
Four novel mutations of the coproporphyrinogen III oxidase gene
Cell. Mol. Biol.
55
15-18
2009
Homo sapiens
Manually annotated by BRENDA team
Sopena, Y.E.; Ferramola de Sancovich, A.M.; Sancovich, H.A.
Hexachlorobenzene treatment on hepatic mitochondrial function parameters and intracellular coproporphyrinogen oxidase location
Int. J. Toxicol.
27
455-465
2008
Rattus norvegicus
Manually annotated by BRENDA team
Li, T.; Woods, J.S.
Cloning, expression, and biochemical properties of CPOX4, a genetic variant of coproporphyrinogen oxidase that affects susceptibility to mercury toxicity in humans
Toxicol. Sci.
109
228-236
2009
Homo sapiens
Manually annotated by BRENDA team
Lash, T.D.; Mani, U.N.; Keck, A.S.; Jones, M.A.
Normal and abnormal heme biosynthesis. 6. Synthesis and metabolism of a series of monovinylporphyrinogens related to harderoporphyrinogen. Further insights into the oxidative decarboxylation of porphyrinogen substrates by coproporphyrinogen oxidase
J. Org. Chem.
75
3183-3192
2010
Saccharomyces cerevisiae, Gallus gallus, Homo sapiens
Manually annotated by BRENDA team
Nagaraj, V.A.; Prasad, D.; Arumugam, R.; Rangarajan, P.N.; Padmanaban, G.
Characterization of coproporphyrinogen III oxidase in Plasmodium falciparum cytosol
Parasitol. Int.
59
121-127
2010
Plasmodium falciparum
Manually annotated by BRENDA team
Goto, T.; Aoki, R.; Minamizaki, K.; Fujita, Y.
Functional differentiation of two analogous coproporphyrinogen III oxidases for heme and chlorophyll biosynthesis pathways in the cyanobacterium Synechocystis sp. PCC 6803
Plant Cell Physiol.
51
650-663
2010
Synechocystis sp., Synechocystis sp. (P72848)
Manually annotated by BRENDA team
Lash, T.D.; Lamm, T.R.; Schaber, J.A.; Chung, W.H.; Johnson, E.K.; Jones, M.A.
Normal and abnormal heme biosynthesis. Part 7. Synthesis and metabolism of coproporphyrinogen-III analogues with acetate or butyrate side chains on rings C and D. Development of a modified model for the active site of coproporphyrinogen oxidase
Bioorg. Med. Chem.
19
1492-1504
2011
Gallus gallus, Homo sapiens
Manually annotated by BRENDA team
Silva, P.J.; Ramos, M.J.
Computational characterization of the substrate-binding mode in coproporphyrinogen III oxidase
J. Phys. Chem. B
115
1903-1910
2011
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Guo, C.Y.; Wu, G.H.; Xing, J.; Li, W.Q.; Tang, D.Z.; Cui, B.M.
A mutation in a coproporphyrinogen III oxidase gene confers growth inhibition, enhanced powdery mildew resistance and powdery mildew-induced cell death in Arabidopsis
Plant Cell Rep.
32
687-702
2013
Arabidopsis thaliana (Q9LR75), Arabidopsis thaliana Col-0 (Q9LR75)
Manually annotated by BRENDA team
Labbe, P.
Purification and properties of coproporphyrinogen III oxidase from yeast
Methods Enzymol.
281
367-378
1997
Saccharomyces cerevisiae (P11353), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Franken, A.C.; Werner, E.R.; Haas, H.; Lokman, B.C.; van den Hondel, C.A.; Ram, A.F.; de Weert, S.; Punt, P.J.
The role of coproporphyrinogen III oxidase and ferrochelatase genes in heme biosynthesis and regulation in Aspergillus niger
Appl. Microbiol. Biotechnol.
97
9773-9785
2013
Aspergillus niger (G3XZT7), Aspergillus niger, Aspergillus niger N402 (G3XZT7)
Manually annotated by BRENDA team
Kim, D.H.; Hino, R.; Adachi, Y.; Kobori, A.; Taketani, S.
The enzyme engineering of mutant homodimer and heterodimer of coproporphyinogen oxidase contributes to new insight into hereditary coproporphyria and harderoporphyria
J. Biochem.
154
551-559
2013
Homo sapiens (P36551), Homo sapiens
Manually annotated by BRENDA team
Anand, S.; Rollakanti, K.R.; Brankov, N.; Brash, D.E.; Hasan, T.; Maytin, E.V.
Fluorouracil enhances photodynamic therapy of squamous cell carcinoma via a p53-independent mechanism that increases protoporphyrin IX levels and tumor cell death
Mol. Cancer Ther.
16
1092-1101
2017
Homo sapiens (P36551), Mus musculus (P36552), Mus musculus
Manually annotated by BRENDA team
Pratibha, P.; Singh, S.K.; Srinivasan, R.; Bhat, S.R.; Sreenivasulu, Y.
Gametophyte development needs mitochondrial coproporphyrinogen III oxidase function
Plant Physiol.
174
258-275
2017
Arabidopsis thaliana
Manually annotated by BRENDA team
Stephenson, J.R.; Stacey, J.A.; Morgenthaler, J.B.; Friesen, J.A.; Lash, T.D.; Jones, M.A.
Role of aspartate 400, arginine 262, and arginine 401 in the catalytic mechanism of human coproporphyrinogen oxidase
Protein Sci.
16
401-410
2007
Homo sapiens (P36551), Homo sapiens
Manually annotated by BRENDA team
Lambie, D.; Florkowski, C.; Sies, C.; Raizis, A.; Siu, W.K.; Towns, C.
A case of hereditary coproporphyria with posterior reversible encephalopathy and novel coproporphyrinogen oxidase gene mutation c.863T>G (p.Leu288Trp)
Ann. Clin. Biochem.
55
616-619
2018
Homo sapiens
Manually annotated by BRENDA team
Modis, K.; Ramanujam, V.; Govar, A.; Lopez, E.; Anderson, K.; Wang, R.; Szabo, C.
Cystathionine-gamma-lyase (CSE) deficiency increases erythropoiesis and promotes mitochondrial electron transport via the upregulation of coproporphyrinogen III oxidase and consequent stimulation of heme biosynthesis
Biochem. Pharmacol.
169
113604
2019
Mus musculus
Manually annotated by BRENDA team
Maytin, E.V.; Anand, S.; Riha, M.; Lohser, S.; Tellez, A.; Ishak, R.; Karpinski, L.; Sot, J.; Hu, B.; Denisyuk, A.; Davis, S.C.; Kyei, A.; Vidimos, A.
5-Fluorouracil enhances protoporphyrin IX accumulation and lesion clearance during photodynamic therapy of actinic keratoses A mechanism-based clinical trial
Clin. Cancer Res.
24
3026-3035
2018
Homo sapiens
Manually annotated by BRENDA team
Ma, J.; Yang, S.; Wang, D.; Tang, K.; Feng, X.X.; Feng, X.Z.
Genetic mapping of a light-dependent lesion mimic mutant reveals the function of coproporphyrinogen III oxidase homolog in soybean
Front. Plant Sci.
11
557
2020
Glycine max
Manually annotated by BRENDA team
Skotnicova, P.; Sobotka, R.; Shepherd, M.; Hajek, J.; Hrouzek, P.; Tichy, M.
The cyanobacterial protoporphyrinogen oxidase HemJ is a new b-type heme protein functionally coupled with coproporphyrinogen III oxidase
J. Biol. Chem.
293
12394-12404
2018
Synechocystis sp. PCC 6803
Manually annotated by BRENDA team
Loskove, Y.; Yasuda, M.; Chen, B.; Nazarenko, I.; Cody, N.; Desnick, R.J.
Acute hepatic porphyrias Identification of 46 hydroxymethylbilane synthase, 11 coproporphyrinogen oxidase, and 20 protoporphyrinogen oxidase novel mutations
Mol. Genet. Metab.
128
352-357
2019
Homo sapiens (P36551), Homo sapiens
Manually annotated by BRENDA team
Moghe, A.; Ramanujam, V.M.S.; Phillips, J.D.; Desnick, R.J.; Anderson, K.E.
Harderoporphyria Case of lifelong photosensitivity associated with compound heterozygous coproporphyrinogen oxidase (CPOX) mutations
Mol. Genet. Metab. Rep.
19
100457
2019
Homo sapiens
Manually annotated by BRENDA team