1.3.3.3: coproporphyrinogen oxidase
This is an abbreviated version!
For detailed information about coproporphyrinogen oxidase, go to the full flat file.
Word Map on EC 1.3.3.3
-
1.3.3.3
-
heme
-
protoporphyrinogen
-
coproporphyria
-
protoporphyrin
-
porphyria
-
ferrochelatase
-
uroporphyrinogen
-
5-aminolevulinic
-
porphobilinogen
-
tetrapyrrole
-
porphyrinogens
-
medicine
-
oxygen-independent
-
coproporphyrinuria
-
mg-protoporphyrin
-
ala-pdt
-
delta-aminolaevulinic
-
uroporphyrin
-
cutanea
-
analysis
- 1.3.3.3
- heme
- protoporphyrinogen
- coproporphyria
- protoporphyrin
- porphyria
-
ferrochelatase
- uroporphyrinogen
-
5-aminolevulinic
- porphobilinogen
- tetrapyrrole
-
porphyrinogens
- medicine
-
oxygen-independent
-
coproporphyrinuria
- mg-protoporphyrin
-
ala-pdt
-
delta-aminolaevulinic
-
uroporphyrin
-
cutanea
- analysis
Reaction
Synonyms
copro'gen oxidase, Coprogen oxidase, coproporphyinogen oxidase, coproporphyrinogen III oxidase, coproporphyrinogen oxidase, coproporphyrinogen-III oxidase, coproporphyrinogenase, COX, CPgen oxidase, CPGox, CPO, CPO III oxidase, CPOX, CPOX4, CPX, CPX1, CPX2, HEM13, Hem13p, HemF, HEMN1, KlHEM13, LIN2, LMM2, O2-dependent coproporphyrinogen III oxidase, oxygen-dependent coproporphyrinogen III oxidase, oxygen-dependent coproporphyrinogen-III oxidase, Sll1185
ECTree
1.3.3.3 coproporphyrinogen oxidaseAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 1.3.3.3 - coproporphyrinogen oxidase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
coproporphyrinogen-III + O2
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
essential enzyme, catalyzes the 6th step in heme biosynthesis
-
-
?
mesoporphyrinogen-VI + O2 + 2 H+
protoaetioporphyrin + 2 CO2 + 2 H2O
-
similar oxidation rate compared to coproporphyrinogen-III
-
?
pentacarboxylate porphyrinogen III + O2
dehydroisocoproporphyrinogen + CO2
-
half of the activity compared to coproporphyrinogen oxidase-III
-
?
protoporphyrinogen-IX + O2
protoporphyrin-IX + CO2
-
capacity to oxidize not only coproporphyrinogen-III but also protoporphyrinogen-IX
-
?
additional information
?
-
-
deleterious enzyme mutations can cause hereditary coproporphyria
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
via harderoporphyrinogen intermediate production, overall reaction
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen III + O2 + H+
protoporphyrinogen IX + CO2 + H2O
-
-
-
?
coproporphyrinogen III + O2 + H+
protoporphyrinogen IX + CO2 + H2O
-
-
-
?
coproporphyrinogen-III + 2 NADP+
protoporphyrinogen-IX + 2 CO2 + 2 NADPH + 2 H+
-
oxidation under anaerobic conditions strictly requires NADP+ as electron acceptor
-
?
coproporphyrinogen-III + 2 NADP+
protoporphyrinogen-IX + 2 CO2 + 2 NADPH + 2 H+
-
oxidation under anaerobic conditions strictly requires NADP+ as electron acceptor
-
?
coproporphyrinogen-III + ?
protoporphyrinogen-IX + ?
-
anaerobic oxidation only in the presence of ATP, NADP+, Mg2+, L-Met, 5-10% of the aerobic activity
-
?
coproporphyrinogen-III + ?
protoporphyrinogen-IX + ?
-
anaerobic enzyme, presence of Mg2+, L-Met, ATP, NADH and NADP+
-
?
coproporphyrinogen-III + ?
protoporphyrinogen-IX + ?
-
anaerobic enzyme, presence of Mg2+, L-Met, ATP, NADH and NADP+
-
-
?
coproporphyrinogen-III + ?
protoporphyrinogen-IX + ?
-
anaerobic enzyme, presence of Mg2+, L-Met, ATP, NADH and NADP+
-
?
coproporphyrinogen-III + ?
protoporphyrinogen-IX + ?
Chromatium sp.
-
anaerobic enzyme, presence of Mg2+, L-Met, ATP, NADH and NADP+
-
?
coproporphyrinogen-III + ?
protoporphyrinogen-IX + ?
-
anaerobic enzyme, presence of Mg2+, L-Met, ATP, NADH and NADP+
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
enzyme is involved in heme and chlorophyll biosynthesis
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
step in heme biosynthesis
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
pathway overview
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
pathway overview
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
6th step in heme biosynthesis, pathway overview
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
key enzyme in the biosynthesis of heme, metabolism overview
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
enzyme is involved in heme and chlorophyll biosynthesis
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
6th step in heme biosynthesis
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
enzyme catalyzes the 6th step in heme biosynthesis, heme might be a feed-back regulator of its synthesis by inhibiting the import of th enzyme into mitochondria
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
highly specific for oxygen as electron acceptor
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
Chromatium sp.
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
Chromatium sp.
-
highly specific for oxygen as electron acceptor
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
highly specific for oxygen as electron acceptor
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
oxygen-independent enzyme has also an aerobic function
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
acts on analogues which possess normal substituents on ring-A to generate a vinyl group on that ring, not active if the ring-A propionate group is changed
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
6th enzyme in heme biosynthetic pathway
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
6th enzyme in heme biosynthetic pathway
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
step-wise decarboxylation of 2- and 4-propionate substituents, both decarboxylations take place at the same active centre
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
highly specific for oxygen as electron acceptor
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
6th enzyme in heme biosynthetic pathway
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
same activity under aerobic and anaerobic conditions
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
aerobic and anaerobic oxidation catalyzed by the same enzyme
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
6th enzyme in heme biosynthetic pathway
-
?
coproporphyrinogen-IV + O2
protoporphyrinogen-XIII + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-IV + O2
protoporphyrinogen-XIII + 2 CO2 + 2 H2O
-
-
-
?
harderoporphyrinogen + O2
protoporphyrinogen IX + CO2 + H2O2
-
30% higher activity compared to coproporphyrinogen-III
-
?
harderoporphyrinogen + O2
protoporphyrinogen IX + CO2 + H2O2
-
intermediate of coproporphyrinogen-III, that is also a substrate
-
?
isoharderoporphyrinogen + O2
protoporphyrinogen IX + CO2 + H2O2
-
3% of the activity compared to coproporphyrinogen-III
-
?
isoharderoporphyrinogen + O2
protoporphyrinogen IX + CO2 + H2O2
-
intermediate of coproporphyrinogen-III that is also a substrate
-
?
