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1.3.3.3: coproporphyrinogen oxidase

This is an abbreviated version!
For detailed information about coproporphyrinogen oxidase, go to the full flat file.

Word Map on EC 1.3.3.3

Reaction

Coproporphyrinogen III
+
O2
 + 2 H+ =
protoporphyrinogen-IX
 + 2 CO2 + 2 H2O

Synonyms

copro'gen oxidase, Coprogen oxidase, coproporphyinogen oxidase, coproporphyrinogen III oxidase, coproporphyrinogen oxidase, coproporphyrinogen-III oxidase, coproporphyrinogenase, COX, CPgen oxidase, CPGox, CPO, CPO III oxidase, CPOX, CPOX4, CPX, CPX1, CPX2, HEM13, Hem13p, HemF, HEMN1, KlHEM13, LIN2, LMM2, O2-dependent coproporphyrinogen III oxidase, oxygen-dependent coproporphyrinogen III oxidase, oxygen-dependent coproporphyrinogen-III oxidase, Sll1185

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.3 With oxygen as acceptor
                1.3.3.3 coproporphyrinogen oxidase

Inhibitors

Inhibitors on EC 1.3.3.3 - coproporphyrinogen oxidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
1,4-Naphthoquinone
-
61% inhibition at 0.015 mM
2,2-bipyridyl
-
77% inhibition of anaerobic reaction at 1.5 mM
2,4,6-Trinitrobenzene
-
60% inhibition at 3.4 mM
2,4-dinitrophenol
5,5-dithiobis(2-nitrobenzoic acid)
Ag+
Chromatium sp.
-
67% inhibition at 1 mM
bis(sulfosuccinimidyl) suberate
-
56% residual activity as compared to not cross-linked enzyme
cetyltrimethylammonium chloride
-
86% inhibition at 0.05%
Co2+
-
inhibition above 5 mM
Coproporphyrin I
-
70% inhibition at 0.0195 mM
Coproporphyrin II
-
61% inhibition at 0.0206 mM
coproporphyrin III
Coproporphyrin IV
-
30% inhibition at 0.0196 mM
Cu2+
-
inhibition at 0.1 mM
diethyl dicarbonate
-
concentration-dependent inhibition, complete inactivation at 50 mM
FAD
-
95% inhibition of anaerobic reaction at 0.03 mM
Fe2+
-
inhibition above 0.1 mM
FMN
-
95% inhibition of anaerobic reaction at 0.03 mM
GSH
-
slight inhibition of aerobic, 41% inhibition of anaerobic enzyme at 5 mM
GSSG
-
31% inhibition of anerobic, 25% inhibition of aerobic enzyme at 5 mM
Harderoporphyrin
-
27% inhibition at 0.02 mM
iodoacetate
KCl
-
70% inhibition at 1 M
L-ethionine
-
inhibition of anaerobic enzyme, 48% at 5 mM
Mn2+
-
inhibition above 5 mM
N-Acetylimidazole
-
90% inhibition at 0.6 mM
N-bromosuccinimide
N-ethylmaleimide
NaCl
-
60% inhibition at 1 M
p-chloromercuribenzene sulfonate
-
40% inhibition at 20 mM
p-chloromercuribenzoate
-
60% inhibition at 1 mM
p-hydroxymercuribenzoate
-
44% inhibition of anaerobic, 23% inhibition of aerobic enzyme at 0.5 mM
p-hydroxyphenylglyoxal
-
55% inhibition at 0.1 mM
Pentacarboxylate porphyrin III
-
10% inhibition at 0.0198 mM
Phenylglyoxal
-
concentration-dependent inhibition, complete inactivation at 50 mM
protoporphyrin-IX
-
inhibition of HemF
riboflavin
-
95% inhibition of anaerobic reaction at 0.03 mM
S-adenosylethionine
-
marked inhibition of anaerobic reaction
S-adenosylhomocysteine
-
marked inhibition of anaerobic reaction
sodium cholate
-
-
sodium deoxycholate
sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-1-carboxylate
-
40% residual activity as compared to not cross-linked enzyme
Tetranitromethane
additional information
-