1.3.3.3: coproporphyrinogen oxidase

This is an abbreviated version!
For detailed information about coproporphyrinogen oxidase, go to the full flat file.

Word Map on EC 1.3.3.3

1.3.3.3

heme

protoporphyrinogen

coproporphyria

protoporphyrin

porphyria

ferrochelatase

uroporphyrinogen

5-aminolevulinic

porphobilinogen

tetrapyrrole

porphyrinogens

medicine

oxygen-independent

coproporphyrinuria

mg-protoporphyrin

ala-pdt

delta-aminolaevulinic

uroporphyrin

cutanea

analysis

Reaction

+ 2 H+ =

+ 2 CO2 + 2 H2O

Synonyms

copro'gen oxidase, Coprogen oxidase, coproporphyinogen oxidase, coproporphyrinogen III oxidase, coproporphyrinogen oxidase, coproporphyrinogen-III oxidase, coproporphyrinogenase, COX, CPgen oxidase, CPGox, CPO, CPO III oxidase, CPOX, CPOX4, CPX, CPX1, CPX2, HEM13, Hem13p, HemF, HEMN1, KlHEM13, LIN2, LMM2, O2-dependent coproporphyrinogen III oxidase, oxygen-dependent coproporphyrinogen III oxidase, oxygen-dependent coproporphyrinogen-III oxidase, Sll1185

ECTree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.3 With oxygen as acceptor

1.3.3.3 coproporphyrinogen oxidase

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Results	in table
40	Activating Compound
17573	AA Sequence
16	Application
1	CAS Registry Number
40	Cloned(Commentary)
11	Cofactor
3	Crystallization (Commentary)
210	Disease/ Diagnostics
5	Expression
34	General Information
5	General Stability
1	IC50 Value
71	Inhibitors
10	kcat/KM [mM/s]
1	Ki Value [mM]
108	KM Value [mM]
51	Localization
26	Metals/Ions
45	Molecular Weight [Da]
101	Natural Substrates/ Products (Substrates)
126	Organism
2	Oxidation Stability
9	Pathway
26	PDB ID
21	pH Optimum
3	pH Range
2	pH Stability
1	pI Value
103	Protein Variants
35	Purification (Commentary)
9	Reaction
5	Reaction Type
110	Reference
101	Source Tissue
19	Specific Activity [micromol/min/mg]
6	Storage Stability
201	Substrates and Products (Substrate)
34	Subunits
124	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
58	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 1.3.3.3 - coproporphyrinogen oxidase

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2-mercaptoethanol

Bos taurus

slight activation

390949, 390964

cardiolipin

Bos taurus

2.2fold activation at 0.5 mg/ml

390964

DTT

Bos taurus

slight activation

390949, 390964

L-alpha-lysophosphatidylcholine

Bos taurus

4.4fold activation at 0.5 mg/ml

390964

L-alpha-lysophosphatidylethanolamine

Bos taurus

3.4fold activation at 0.5 mg/ml

390964

L-alpha-phosphatidyl-DL-glycerol

Bos taurus

2.7fold activation at 0.5 mg/ml

390964

L-alpha-phosphatidyl-L-serine

Bos taurus

2.8fold activation at 0.5 mg/ml

390964

L-alpha-phosphatidylcholine

2 entries

L-alpha-Phosphatidylethanolamine

Bos taurus

3.9fold activation at 0.5 mg/ml

L-methionine

lecithin

Lipids

bovine liver lipids, 3.6fold activation at 1 mg/ml

390964

methotrexate

Homo sapiens

causes a 3fold accumulation of CPO at both the mRNA and protein levels

Non-ionic detergents

oxygen

phosphatidate

phosphatidyl glycerol

Rattus sp.

activation in intact and sonicated mitochondria up to 135%

390943

Phospholipids

2 entries

pyruvate

Saccharomyces cerevisiae

50% activation at 50 mM

390974

S-adenosyl-L-methionine

Chromatium sp.

can replace NADP+-NADH in anaerobic reaction

Triton X-100

Tween 20

Tween 40

2.2fold activation at 0.2%, v/v

390964

Tween 60

Bos taurus

2.3fold activation at 0.2%, v/v

390964

Tween 80

Bos taurus

2fold activation at 0.2%, v/v

390964

Tween 85

Bos taurus

1.8 fold activation at 0.2%, v/v

390964