1.3.1.B13: polyprenol reductase (NADPH)

This is an abbreviated version!
For detailed information about polyprenol reductase (NADPH), go to the full flat file.

Reaction

Synonyms

polyprenol reductase, polyprenol reductase 1, polyprenol reductase 2, polyprenol reductase2, PPRD1, PPRD2, SRD5A3

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.1 With NAD⁺ or NADP⁺ as acceptor

                1.3.1.B13 polyprenol reductase (NADPH)

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3	AA Sequence
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4	Disease/ Diagnostics
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6	Localization
4	Natural Substrates/ Products (Substrates)
7	Organism
1	pH Optimum
9	Protein Variants
1	Reaction
5	Reference
15	Source Tissue
5	Substrates and Products (Substrate)
15	Synonyms
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1	Temperature Optimum [°C]

Substrates Products

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Substrates Products on EC 1.3.1.B13 - polyprenol reductase (NADPH)

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

a dolichol + NADP+

a polyprenol + NADPH + H+

Homo sapiens

Q9H8P0

reduction of the alpha-isoprene subunit of polyprenol

719256

-

-

?

a polyprenol + NADPH + H+

a dolichol + NADP+

4 entries

a polyprenol + NADPH + H+

a dolichol + NADP+

Arabidopsis thaliana

Q9CAH5, Q9SI62

-

746028

-

-

?

a polyprenol + NADPH + H+

a dolichol + NADP+

Arabidopsis thaliana Col-0

Q9CAH5, Q9SI62

-

746028

-

-

?

a polyprenol + NADPH + H+

a dolichol + NADP+

Homo sapiens

Q9H8P0

-

743987

-

-

?

a polyprenol + NADPH + H+

a dolichol + NADP+

Homo sapiens

Q9H8P0

the enzyme (SRD5A3) is necessary for the reduction of the alpha-isoprene unit of polyprenols to form alpha-reduced dolichols, required for synthesis of dolichol-linked monosaccharides, and the oligosaccharide precursor used for N-glycosylation. The presence of residual dolichol in cells depleted for this enzyme suggests the existence of an unexpected alternative pathway for dolichol de novo biosynthesis

719256

-

-

?