1.3.1.93: very-long-chain enoyl-CoA reductase
This is an abbreviated version!
For detailed information about very-long-chain enoyl-CoA reductase, go to the full flat file.
Word Map on EC 1.3.1.93
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1.3.1.93
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cuticular
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vlcfas
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sphingolipids
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acyl-coas
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triacylglycerols
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piecemeal
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taxus
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antidiabetic
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eceriferum
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sumatrana
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alkane
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invaginations
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endophytic
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nucleus-vacuole
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cuticle
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colletotrichum
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elongase
- 1.3.1.93
- cuticular
-
vlcfas
- sphingolipids
- acyl-coas
- triacylglycerols
-
piecemeal
- taxus
-
antidiabetic
-
eceriferum
- sumatrana
- alkane
-
invaginations
-
endophytic
-
nucleus-vacuole
- cuticle
- colletotrichum
- elongase
Reaction
Synonyms
At3g55360, CER10, EC 2.3.1.119, ECR, ECR1, ECR2, enoyl reductase, TER, trans-2-enoyl-CoA reductase, TSC13, very-long-chain enoyl-CoA reductase
ECTree
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General Information
General Information on EC 1.3.1.93 - very-long-chain enoyl-CoA reductase
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malfunction
metabolism
physiological function
additional information
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homology modeling of Tsc13 based on the structure of a trans-2-enoyl reductase from Homo sapiens, PDB ID 1YXM
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ectopic expression of human trans-2-enoyl-CoA reductase TER in Saccharomyces cerevisiae TER homologue Tsc13-lowered cells causes recovery in the deficient sphingosine 1-phosphate metabolic pathway, lethality of VLCFA-deficient mutations
malfunction
in membrane fractions prepared from TER siRNA-treated HeLa cells, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA is largely impaired, and only a small amount of palmitoyl-CoA is produced. Instead, trans-2-hexadecenoyl-CoA is the main product, and C14:0-CoA is also detected
malfunction
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ectopic expression of human trans-2-enoyl-CoA reductase TER in Saccharomyces cerevisiae TER homologue Tsc13-lowered cells causes recovery in the deficient sphingosine 1-phosphate metabolic pathway, lethality of VLCFA-deficient mutations
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enzyme Tsc13p is sequestered into nucleus-vacuole junctions from the peripheral endoplasmic reticulum through Vac8p-independent interactions with Nvj1p. During nutrient limitation, Tsc13p is incorporated into piecemeal microautophagy vesicles in an Nvj1p-dependent manner. The lumenal diameters of piecemeal microautophagy blebs and vesicles are significantly reduced in tsc13 and tsc13 elo3 mutant cells. Piecemeal microautophagy structures are also smaller in cells treated with cerulenin, an inhibitor of de novo fatty acid synthesis and elongation. The targeting of Tsc13p-green fluorescent protein into nucleus-vacuole junctions is perturbed by cerulenin
metabolism
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TER is involved sphingosine degradation within sphingolipids in the S1P metabolic pathway. trans-2-enoyl-CoA reductase TER catalyzes the saturation step of the sphingosine 1-phosphate (S1P) metabolic pathway. The pathways of sphingolipid degradation and synthesis, overview
metabolism
TER is involved sphingosine degradation within sphingolipids in the S1P metabolic pathway. trans-2-enoyl-CoA reductase TER catalyzes the saturation step of the sphingosine 1-phosphate (S1P) metabolic pathway. The pathways of sphingolipid degradation and synthesis, overview
metabolism
TER is involved sphingosine degradation within sphingolipids in the S1P metabolic pathway. trans-2-enoyl-CoA reductase TER catalyzes the saturation step of the sphingosine 1-phosphate (S1P) metabolic pathway. The pathways of sphingolipid degradation and synthesis, overview. Ectopic expression of human trans-2-enoyl-CoA reductase TER in Saccharomyces cerevisiae TER homologue Tsc13-lowered cells causes recovery in the deficient sphingosine 1-phosphate metabolic pathway
metabolism
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TER is involved sphingosine degradation within sphingolipids in the S1P metabolic pathway. trans-2-enoyl-CoA reductase TER catalyzes the saturation step of the sphingosine 1-phosphate (S1P) metabolic pathway. The pathways of sphingolipid degradation and synthesis, overview
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gene disruption results in a reduction of cuticular wax load and affects very long chain fatty acid composition of seed triacylglycerols and sphingolipids. Epidermal and seed-specific silencing of enzyme activity results in a reduction of cuticular wax load and the very long chaind fatty acid content of seed triacylglycerols, respectively, with no effects on plant morphogenesis. Cellular analysis reveals aberrant endocytic membrane traffic and defective cell expansion underlying the morphological defects of the disruption mutants
physiological function
heterologous expression functionally complements the temperature-sensitive phenotype of a yeast tsc13 mutant that is dfficient in enoyl reductase activity
physiological function
heterologous expression functionally complements the temperature-sensitive phenotype of a yeast tsc13 mutant that is dfficient in enoyl reductase activity. The heterologous protein interacts physically with the Elo2p and Elo3p components of the yeast elongase complex. Gene apparently encodes the sole enoyl reductase activity associated with microsomal fatty acid elongation in Arabidopsis thaliana
physiological function
heterologous expression functionally complements the temperature-sensitive phenotype of a yeast tsc13 mutant that is dfficient in enoyl reductase activity. Tsc13 cells expressing the reductase produce very long chain fatty acids, espcially C26:0
physiological function
the tsc13 mutant accumulates high levels of long-chain bases as well as ceramides that harbor fatty acids with chain lengths shorter than 26 carbons. These phenotypes are exacerbated by the deletion of either the ELO2 or ELO3 gene, both of which are required for synthesis of very long chain fatty acids. Compromising the synthesis of malonyl coenzyme A by inactivating acetyl-CoA carboxylase in a tsc13 mutant is lethal
physiological function
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the enoyl reductase Tsc13 is responsible for the accumulation of phloretic acid via reduction of p-coumaroyl-CoA. Tsc13 is an essential enzyme involved in fatty acid synthesis and cannot be deleted
physiological function
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the trans-2-enoyl-CoA reductase, TER, functions in very long-chain fatty acid (VLCFA) synthesis and is involved in the fatty acid elongation cycle, where palmitic acid synthesized by fatty acid synthase or fatty acids taken from foods are elongated to very long-chain fatty acids (VLCFAs) with carbon chain lengths greater than 20
physiological function
the trans-2-enoyl-CoA reductase, TER, functions in very long-chain fatty acid (VLCFA) synthesis and is involved in the fatty acid elongation cycle, where palmitic acid synthesized by fatty acid synthase or fatty acids taken from foods are elongated to very long-chain fatty acids (VLCFAs) with carbon chain lengths greater than 20
physiological function
the trans-2-enoyl-CoA reductase, TER, functions in very long-chain fatty acid (VLCFA) synthesis and is involved in the fatty acid elongation cycle, where palmitic acid synthesized by fatty acid synthase or fatty acids taken from foods are elongated to very long-chain fatty acids (VLCFAs) with carbon chain lengths greater than 20
physiological function
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the trans-2-enoyl-CoA reductase, TER, functions in very long-chain fatty acid (VLCFA) synthesis and is involved in the fatty acid elongation cycle, where palmitic acid synthesized by fatty acid synthase or fatty acids taken from foods are elongated to very long-chain fatty acids (VLCFAs) with carbon chain lengths greater than 20
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