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1.3.1.9: enoyl-[acyl-carrier-protein] reductase (NADH)

This is an abbreviated version!
For detailed information about enoyl-[acyl-carrier-protein] reductase (NADH), go to the full flat file.

Word Map on EC 1.3.1.9

Reaction

an acyl-[acyl-carrier protein]
+
NAD+
=
a trans-2,3-dehydroacyl-[acyl-carrier protein]
 +
NADH
 +
H+

Synonyms

2-trans enoyl-ACP-reductase, 2-trans enoyl-acyl carrier protein reductase, 2-trans-enoyl-ACP (CoA) reductase, 2-trans-enoyl-ACP reductase, 2-trans-enoyl-ACP(CoA) reductase, ACP reductase, BaENR, BMA0885, bsFabI, cold-shock induced protein 15, CSI15, EACP reductase, enoyl (acyl carrier protein) reductase, enoyl ACP reductase, enoyl acyl carrier protein reductase, enoyl acyl carrier protein reductase InhA, enoyl reductase, enoyl-ACP reductase, enoyl-ACP reductase I, enoyl-ACP reductase III, enoyl-ACP(CoA) reductase, enoyl-acyl carrier protein, enoyl-acyl carrier protein reductase, enoyl-acyl carrier protein reductase I, enoyl-reductase, enoyl-[acyl-carrier-protein] reductase, ENR, ENR1, ENR2, FabI, FabI-1, FabI-related enoyl-ACP reductase, FabI1, FabI2, FabK, Fabl1, Fabl2, FabMG, FabV, FAS-II enoyl reductase, FTT_0782, InhA, More, MtENR, MtInhA, NAD-dependent enoyl-ACP reductase, NADH-dependent enoyl reductase, NADH-dependent enoyl-ACP reductase, NADH-dependent enoyl-acyl carrier protein reductase, NADH-enoyl acyl carrier protein reductase, NADH-ENR, NADH-specific enoyl-ACP reductase, OsmC, PA2950, pfENR, reductase, enoyl-[acyl carrier protein], trans-enoyl-[acyl carrier protein] reductase, trans-enoyl-[acyl-carrier-protein] reductase, VEG241, vegetative protein 241, VF_0888, YP_4011

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.9 enoyl-[acyl-carrier-protein] reductase (NADH)

KI Value

KI Value on EC 1.3.1.9 - enoyl-[acyl-carrier-protein] reductase (NADH)

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000016 - 0.00017
(2E)-3-(1,2,3,4,5,6-hexahydropyrido[2,3-b][1,5]diazocin-8-yl)-N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]prop-2-enamide
0.000026 - 0.000055
(2E)-N-(3-methoxy-2-propoxybenzyl)-N-methyl-3-(1'-methyl-2-oxo-1,4-dihydro-2H-spiro[1,8-naphthyridine-3,4'-piperidin]-6-yl)prop-2-enamide
0.000071
(2E)-N-(3-methoxy-2-propoxybenzyl)-N-methyl-3-(2-oxo-1,4-dihydro-2H-spiro[1,8-naphthyridine-3,4'-piperidin]-6-yl)prop-2-enamide
-
-
0.000132
(2E)-N-methyl-N-[(1-methyl-1H-indol-2-yl)methyl]-3-(2-oxo-1,4-dihydro-2H-spiro[1,8-naphthyridine-3,4'-piperidin]-6-yl)prop-2-enamide
-
-
0.00013 - 0.00033
(2E)-N-methyl-N-[(1-methyl-1H-indol-2-yl)methyl]-3-(2-oxo-2,3,4,5-tetrahydro-1H-pyrido[2,3-e][1,4]diazepin-7-yl)prop-2-enamide
0.00051
(2E)-N-methyl-N-[(1-methyl-1H-indol-2-yl)methyl]-3-(4-methyl-2-oxo-2,3,4,5-tetrahydro-1H-pyrido[2,3-e][1,4]diazepin-7-yl)prop-2-enamide
-
-
0.00013 - 0.000136
(2E)-N-methyl-N-[(1-methyl-1H-indol-2-yl)methyl]-3-(4-oxo-2,3,4,5-tetrahydro-1H-pyrido[2,3-b][1,4]diazepin-8-yl)prop-2-enamide
0.0000018 - 0.00002
(2E)-N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]-3-(1'-methyl-2-oxo-1,4-dihydro-2H-spiro[1,8-naphthyridine-3,4'-piperidin]-6-yl)prop-2-enamide
0.000012 - 0.000067
(2E)-N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]-3-(2,3,4,5-tetrahydro-1H-pyrido[2,3-b][1,4]diazepin-8-yl)prop-2-enamide
0.000014 - 0.000048
(2E)-N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]-3-(2,3,4,5-tetrahydro-1H-pyrido[2,3-e][1,4]diazepin-7-yl)prop-2-enamide
0.000017 - 0.000049
(2E)-N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]-3-(2-oxo-1,4-dihydro-2H-spiro[1,8-naphthyridine-3,4'-piperidin]-6-yl)prop-2-enamide
0.000029 - 0.000043
(2E)-N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]-3-(2-oxo-2,3,4,5-tetrahydro-1H-pyrido[2,3-e][1,4]diazepin-7-yl)prop-2-enamide
0.000039 - 0.00006
(2E)-N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]-3-(3-oxo-2,3,4,5-tetrahydro-1H-pyrido[2,3-e][1,4]diazepin-7-yl)prop-2-enamide
0.00003 - 0.000061
(2E)-N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]-3-(4-oxo-1,2,3,4,5,6-hexahydropyrido[2,3-b][1,5]diazocin-8-yl)prop-2-enamide
0.000007 - 0.000025
(2E)-N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]-3-(4-oxo-2,3,4,5-tetrahydro-1H-pyrido[2,3-b][1,4]diazepin-8-yl)prop-2-enamide
0.0000024 - 0.000014
(2E)-N-methyl-N-[(3-methyl-1-benzothiophen-2-yl)methyl]-3-(1'-methyl-2-oxo-1,4-dihydro-2H-spiro[1,8-naphthyridine-3,4'-piperidin]-6-yl)prop-2-enamide
0.000014 - 0.000026
(2E)-N-methyl-N-[(3-methyl-1-benzothiophen-2-yl)methyl]-3-(2,3,4,5-tetrahydro-1H-pyrido[2,3-b][1,4]diazepin-8-yl)prop-2-enamide
0.000009 - 0.000057
(2E)-N-methyl-N-[(3-methyl-1-benzothiophen-2-yl)methyl]-3-(2,3,4,5-tetrahydro-1H-pyrido[2,3-e][1,4]diazepin-7-yl)prop-2-enamide
0.0000004 - 0.000048
(2E)-N-methyl-N-[(3-methyl-1-benzothiophen-2-yl)methyl]-3-(2-oxo-1,4-dihydro-2H-spiro[1,8-naphthyridine-3,4'-piperidin]-6-yl)prop-2-enamide
0.00003
(2E)-N-methyl-N-[(3-methyl-1-benzothiophen-2-yl)methyl]-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)prop-2-enamide
-
-
0.0000007 - 0.000026
(2E)-N-methyl-N-[(3-methyl-1-benzothiophen-2-yl)methyl]-3-[3-(2-morpholin-4-ylethyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-6-yl]prop-2-enamide
0.0002 - 0.00084
(2E)-N-methyl-N-[(3-methyl-1H-indol-2-yl)methyl]-3-(4-oxo-2,3,4,5-tetrahydro-1H-pyrido[2,3-b][1,4]diazepin-8-yl)prop-2-enamide
0.000024 - 0.000028
(2E)-N-[(5-fluoro-3-methyl-1-benzothiophen-2-yl)methyl]-N-methyl-3-(1'-methyl-2-oxo-1,4-dihydro-2H-spiro[1,8-naphthyridine-3,4'-piperidin]-6-yl)prop-2-enamide
0.000025 - 0.000031
(2E)-N-[(5-fluoro-3-methyl-1-benzothiophen-2-yl)methyl]-N-methyl-3-(4-oxo-2,3,4,5-tetrahydro-1H-pyrido[2,3-b][1,4]diazepin-8-yl)prop-2-enamide
0.0000023 - 0.0000043
(E)-N-methyl-N-(1-methyl-1H-indol-2-ylmethyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide
0.000096 - 0.000104
2-(2'-amino-4'-chloro-phenoxy)-5-chloro-phenol
0.0001
2-(2-amino-4-chlorophenoxy)-5-chlorophenol
pH not specified in the publication, temperature not specified in the publication
0.0136
2-(3-hydroxy-5-methylphenoxy)-5-methoxy-3-methyl phenol
-
in 10 mM sodium phosphate, pH 7.2, at 25°C
0.000000022 - 0.000022
2-(o-tolyloxy)-5-hexylphenol
0.0002
2-decyl-1-methyl-5-(4-nitrophenoxy)pyridin-4(1H)-one
IC50 above 0.05 mM, wild type enzyme, at pH 8.0 and 30°C
0.000018 - 0.000091
3-bromo-N-(4-fluorobenzyl)-1-benzothiophene-2-carboxamide
0.00013 - 0.00062
3-formyl-2-phenoxy phenol
0.00013
3-hydroxy-4-phenoxybenzaldehyde
pH not specified in the publication, temperature not specified in the publication
0.00018 - 0.001
4-(2',4'-dichlorophenoxy)-3-hydroxybenzaldehyde
0.00021 - 0.0013
4-(2',4'-dichlorophenoxy)-3-hydroxybenzoic acid
0.00038 - 0.00185
4-(2',4'-dichlorophenoxy)-3-hydroxybenzyl alcohol
0.00032 - 0.00275
4-(2',4'-dichlorophenoxy)-3-hydroxybenzylchloride
0.00018
4-(2,4-dichlorophenoxy)-3-hydroxybenzaldehyde
pH not specified in the publication, temperature not specified in the publication
0.008
4-decyl-1-[(4-nitrophenyl)methyl]pyridin-2(1H)-one
wild type enzyme, at pH 8.0 and 30°C
0.0001
5-decyl-2-(4-nitrophenoxy)phenol
wild type enzyme, at pH 8.0 and 30°C
0.00004 - 0.0021
acetoacetyl-CoA
2.4
CoASH
-
-
0.015
curcumin
pH 7.5, 22°C
0.9
decanoyl-CoA
-
at pH 7.5 and 30°C
0.0084 - 0.29
diazaborine
0.0000106 - 0.000084
epigallocatechin gallate
0.0001 - 0.00015
indole
0.00011 - 0.0068
isoniazid
0.0071
luteolin
pH 7.5, 22°C
0.000029 - 0.022
NADH
0.0054
palmitic acid
-
at pH 7.5 and 30°C
0.02
palmitoyl-CoA
-
-
0.04
pentacyano (isoniazid)ferrate-II
-
pH 7.5, 25°C
0.000011
sodium (4-[2-[([[5-(pyridin-2-ylsulfanyl)-1,3-thiazol-2-yl]carbamoyl]amino)methyl]-1H-imidazol-4-yl]phenoxy)acetate
-
0.00000003 - 0.036
triclosan
0.002 - 0.18
triclosane
additional information
additional information
-