1.3.1.72: DELTA24-sterol reductase

This is an abbreviated version!
For detailed information about DELTA24-sterol reductase, go to the full flat file.

Reaction

Synonyms

24,25-reductase, 24,25-sterol reductase, 24-dehydrocholesterol reductase, 24-reductase, 3 beta-hydroxysteroid-DELTA 24 reductase, 3-beta-hydroxysterol-DELTA24-reductase, 3beta -hydroxysterol DELTA24-reductase, 3beta-hydroxysteroid-DELTA24 reductase, 3beta-hydroxysterol DELTA24-reductase, 3beta-hydroxysterol-delta24 reductase, ArDWF1, C-24 reductase, dehydrocholesterol reductase, DELTA24 reductase, DELTA24-dehydrocholesterol reductase, DELTA24-reductase, DELTA24-sterol-DELTA24-reductase, desmosterol reductase, DHCR24, DHCR24-1, DHCR24-2, DIM, DIMINUTO/DWARF1, Dimunito/Dwarf1, DWARF1, DWF1, hydroxy steroid DELTA24-reductase, lanosterol 24-reductase, lanosterol DELTA24-reductase, lanosterol reductase, More, OsDWF1, reductase, hydroxy steroid DELTA24-, seladin-1, sterol 24,25-reductase, sterol 24-reductase, sterol 24DELTA-reductase, sterol C-24 reductase, sterol DELTA24 reductase, sterol DELTA24-reductase, sterol-DELTA24-reductase, ZmDWF1

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.1 With NAD⁺ or NADP⁺ as acceptor

                1.3.1.72 DELTA24-sterol reductase

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Results	in table
8	Activating Compound
32	AA Sequence
5	Application
1	CAS Registry Number
20	Cloned(Commentary)
34	Cofactor
351	Disease/ Diagnostics
13	Expression
42	General Information
17	IC50 Value
77	Inhibitors
7	Ki Value [mM]
10	KM Value [mM]
34	Localization
2	Molecular Weight [Da]
54	Natural Substrates/ Products (Substrates)
49	Organism
1	Oxidation Stability
12	Pathway
5	pH Optimum
3	Posttranslational Modification
35	Protein Variants
2	Purification (Commentary)
9	Reaction
3	Reaction Type
49	Reference
79	Source Tissue
3	Specific Activity [micromol/min/mg]
116	Substrates and Products (Substrate)
4	Subunits
113	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]

IC50 Value

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IC50 Value on EC 1.3.1.72 - DELTA24-sterol reductase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0000029

(1R,3aR,5aS,7S,9aS,9bR,11aR)-9a,11a-dimethyl-1-[(2R,3E)-4-phenylbut-3-en-2-yl]-2,3,3a,5,5a,6,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[a]phenanthren-7-ol

Homo sapiens

-

at 37°C, pH not specified in the publication

764619

-

0.000823

(2S)-2-[(1R,3aR,5aS,7S,9aS,9bR,11aR)-7-hydroxy-9a,11a-dimethyl-2,3,3a,5,5a,6,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[a]phenanthren-1-yl]-N-methylpropanamide

Homo sapiens

-

at 37°C, pH not specified in the publication

764619

-

0.000198

(3S,20S)-20-(aminomethyl)-pregn-7-en-3-yl acetate

Homo sapiens

-

at 37°C, pH not specified in the publication

764619

-

0.0000001

(3S,20S)-20-(hydroxymethyl)-pregn-7-en-3-ol

Homo sapiens

-

at 37°C, pH not specified in the publication

764619

-

0.000805

(3S,20S)-20-(methoxyaminocarbonyl)-pregn-7-en-3-ylacetate

Homo sapiens

-

at 37°C, pH not specified in the publication

764619

-

0.000203

(3S,20S)-20-[((E)-2-methylbut-2-enoyloxy)methyl]-pregn-7-en-3-yl acetate

Homo sapiens

-

at 37°C, pH not specified in the publication

764619

-

0.0000063

(3S,20S)-20-[((E)-but-2-enoyloxy)methyl]-pregn-7-en-3-yl acetate

Homo sapiens

-

at 37°C, pH not specified in the publication

764619

-

0.0169

(3S,20S)-20-[(butanoylamino)methyl]-pregn-7-en-3-ylacetate

Homo sapiens

-

at 37°C, pH not specified in the publication

764619

-

0.0000055

(3S,20S)-20-[(dimethylamino)acetoxymethyl]-pregn-7-en-3-yl acetate

Homo sapiens

-

at 37°C, pH not specified in the publication

764619

-

0.0000042

(3S,20S)-20-[(formyloxy)methyl]-pregn-7-en-3-yl acetate

Homo sapiens

-

at 37°C, pH not specified in the publication

764619

-

0.0000025

(7S,9aR,11aS)-1-[(2S)-1-hydroxypropan-2-yl]-9a,11a-dimethyl-2,3,3a,3b,4,6,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[a]phenanthren-7-ol

Homo sapiens

-

at 37°C, pH not specified in the publication

764619

-

0.0000033

(7S,9aS,11aR)-1-[(2S)-1-hydroxypropan-2-yl]-9a,11a-dimethyl-2,3,3a,5,5a,6,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[a]phenanthren-7-yl acetate

Homo sapiens

-

at 37°C, pH not specified in the publication

764619

-

0.002

24(R,S),25-epimino-lanosterol

Manduca sexta

-

iminiolanosterol, IL, potent inhibitor, IC50: 0.002 mM

288498

0.00015

3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one

Rattus norvegicus

-

U18666A, non-competitive inhibition, Ki: 0.000157 mM, IC50 about 0.00015 mM, 690fold higher affinity for the enzyme than substrate lanosterol

288496

1.019

hesperidin

Leishmania donovani

E9BQ02

pH and temperature not specified in the publication

763824

0.000005

SH42

Mus musculus

-

pH and temperature not specified in the publication

765679

-

0.0008

Triparanol

Rattus norvegicus

-

non-competitive inhibition, specific inhibitor, Ki: 0.000523 mM, IC50 about 0.0008 mM, 208fold higher affinity for the enzyme than substrate lanosterol

288496