1.3.1.71: DELTA24(241)-sterol reductase

This is an abbreviated version!
For detailed information about DELTA24(241)-sterol reductase, go to the full flat file.

Word Map on EC 1.3.1.71

1.3.1.71

brefeldin

tridemorph

lamin

copper

schizosaccharomyces

fenpropimorph

pombe

azasterol

Reaction

Synonyms

24-methylene sterol 24(28)-reductase, C-24(28) reductase, C-24(28) sterol reductase, C24(28) reductase, DELTA24(28)-sterol methylreductase, Erg4p, Erg6, S-adenosylmethionine:sterol C-24 methyltransferase, SAM:SMT, SMR, sterol DELTA24(28)-methylene reductase, sterol DELTA24(28)-reductase

ECTree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.1.71 DELTA24(241)-sterol reductase

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Results	in table
1	Activating Compound
40	AA Sequence
1	CAS Registry Number
4	Cloned(Commentary)
6	Cofactor
2	General Stability
6	Inhibitors
1	KM Value [mM]
2	Localization
1	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
12	Organism
6	Pathway
2	pH Optimum
1	pH Range
4	Protein Variants
1	Purification (Commentary)
2	Reaction
12	Reference
1	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
22	Substrates and Products (Substrate)
1	Subunits
18	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Inhibitors

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Inhibitors on EC 1.3.1.71 - DELTA24(241)-sterol reductase

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20-piperidin-2-yl-5alpha-pregnan-20(R),3beta-diol

Paracoccidioides brasiliensis

i.e. AZA-1, inhibits the enzyme and the DELTA24-sterol methyltransferase, leads to accumulation of ergosta-5,7,24(28)-trien-3beta-ol in vivo

654205

22-piperidin-2-yl-5alpha-pregnan-3beta,22(S)-diol

Paracoccidioides brasiliensis

i.e. AZA-2, specific inhibition of the enzyme, leads to accumulatin of ergosta-5,7,22,24(28)-tetraen-3beta-ol in vivo

654205

22-piperidin-3-yl-5alpha-pregnan-3beta,22(S)-diol

Paracoccidioides brasiliensis

i.e. AZA-3, inhibits the enzyme, major proliferative effect and accumulation of lanosterol in vivo

654205

23-Azacholesterol

2 entries

additional information

Paracoccidioides brasiliensis

sterol composition with or without addition of azasterol analogue inhibitors, overview

654205