1.3.1.70: DELTA14-sterol reductase

This is an abbreviated version!
For detailed information about DELTA14-sterol reductase, go to the full flat file.

Reaction

Synonyms

14-dehydrocholesterol reductase, 14-reductase, 14-SR, 3 beta-hydroxysterol-DELTA14-reductase, 3beta-hydroxysterol DELTA14-reductase, C-14 reductase, C-14 sterol reductase, C14-SR, C14-sterol reductase, C14SR, DELTA14-reductase, DELTA14-SR, DELTA14SR, DELTA7,14-steroid 14-reductase, DELTA7,14-sterol 14-reductase, DELTA7,14-sterol DELTA14-reductase, DELTA7,14-sterol-14-reductase, DELTA8,14-hydroxy steroid DELTA14(15)-reductase, DELTA8,14-steroid 14-reductase, DELTA8,14-sterol 14-reductase, DELTA8,14-sterol DELTA14-reductase, DELTA8,14-sterol-14-reductase, DHCR14, ERG 24, ERG24, erg24-1, erg24A, erg24B, fackel, FACKEL protein, FgERG24A, FgERG24B, FK, fk-J3158, integral membrane sterol reductase, lamin B receptor, lamin-B receptor, LBR, MaSR1, reductase, DELTA8,14-hydroxy steroid DELTA14(15)-, SR-1, sterol 14-reductase, sterol C-14 reductase, sterol C14-reductase, sterol DELTA14,15-reductase, sterol DELTA14-reductase, TM7SF2

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.1 With NAD⁺ or NADP⁺ as acceptor

                1.3.1.70 DELTA14-sterol reductase

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Results	in table
10	Activating Compound
966	AA Sequence
3	Application
1	CAS Registry Number
16	Cloned(Commentary)
25	Cofactor
1	Crystallization (Commentary)
92	Disease/ Diagnostics
8	Expression
20	General Information
7	General Stability
12	IC50 Value
82	Inhibitors
16	KM Value [mM]
35	Localization
1	Metals/Ions
6	Molecular Weight [Da]
44	Natural Substrates/ Products (Substrates)
40	Organism
15	Pathway
2	PDB ID
6	pH Optimum
6	pH Range
61	Protein Variants
7	Purification (Commentary)
10	Reaction
3	Reaction Type
36	Reference
64	Source Tissue
2	Specific Activity [micromol/min/mg]
2	Storage Stability
100	Substrates and Products (Substrate)
6	Subunits
90	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]

Synonyms

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Synonyms on EC 1.3.1.70 - DELTA14-sterol reductase

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

14-dehydrocholesterol reductase

Homo sapiens

O76062

-

765069

14-reductase

-

-

-

-

14-SR

Oryctolagus cuniculus

-

-

713446

3 beta-hydroxysterol-DELTA14-reductase

Mus musculus

Q71KT5

-

744648

3beta-hydroxysterol DELTA14-reductase

3 entries

C-14 reductase

3 entries

C-14 sterol reductase

3 entries

C14-SR

2 entries

C14-sterol reductase

Homo sapiens

O76062, Q14739

-

765069

C14SR

3 entries

DELTA14-reductase

2 entries

DELTA14-SR

-

-

-

-

DELTA14SR

-

-

-

-

DELTA7,14-steroid 14-reductase

-

-

-

-

DELTA7,14-sterol 14-reductase

-

-

-

-

DELTA7,14-sterol DELTA14-reductase

-

-

-

-

DELTA7,14-sterol-14-reductase

-

-

-

-

DELTA8,14-hydroxy steroid DELTA14(15)-reductase

-

-

-

-

DELTA8,14-steroid 14-reductase

-

-

-

-

DELTA8,14-sterol 14-reductase

-

-

-

-

DELTA8,14-sterol DELTA14-reductase

-

-

-

-

DELTA8,14-sterol-14-reductase

-

-

-

-

DHCR14

Homo sapiens

O76062

-

765069

ERG 24

Saccharomyces cerevisiae

-

ERG24 represents C-14 reductase

288494

ERG24

7 entries

erg24-1

Saccharomyces cerevisiae

-

-

288494

erg24A

2 entries

erg24B

2 entries

fackel

Arabidopsis thaliana

Q9LDR4

-

746161

FACKEL protein

-

-

-

-

FgERG24A

Fusarium graminearum

-

-

725903

FgERG24B

Fusarium graminearum

-

-

725903

FK

Arabidopsis thaliana

-

-

657046

fk-J3158

Arabidopsis thaliana

Q9LDR4

-

746161

integral membrane sterol reductase

2 entries

lamin B receptor

Homo sapiens

-

-

672378

lamin-B receptor

Homo sapiens

Q14739

-

765069

LBR

2 entries

MaSR1

2 entries

reductase, DELTA8,14-hydroxy steroid DELTA14(15)-

-

-

-

-

SR-1

Homo sapiens

-

-

656304

sterol 14-reductase

-

-

-

-

sterol C-14 reductase

9 entries

sterol C14-reductase

-

-

-

-

sterol DELTA14,15-reductase

-

-

-

-

sterol DELTA14-reductase

2 entries

TM7SF2

4 entries

3beta-hydroxysterol DELTA14-reductase

Homo sapiens

-

besides the endoplasmic reticulum 3beta-hydroxysterol DELTA14-reductase (C14SR) encoded by TM7SF2 gene, the lamin B receptor (LBR) of the inner nuclear membrane possesses 3beta-hydroxysterol DELTA14-reductase activity

672378

3beta-hydroxysterol DELTA14-reductase

Homo sapiens

O76062

-

654166, 711302

3beta-hydroxysterol DELTA14-reductase

Mus musculus

Q71KT5

-

744648

C-14 reductase

-

-

-

-

C-14 reductase

Arabidopsis thaliana

Q9LDR4

-

746161

C-14 reductase

Candida albicans

-

-

725863

C-14 sterol reductase

-

-

-

-

C-14 sterol reductase

Neurospora crassa

P38670

-

764764

C-14 sterol reductase

Neurospora crassa DSM 1257

P38670

-

-

C14-SR

Homo sapiens

O76062, Q14739

-

765069

C14-SR

Mus musculus

Q71KT5

-

744648

C14SR

Homo sapiens

-

-

672378

C14SR

Methylotuvimicrobium alcaliphilum

G4SW86

-

745882

C14SR

Methylotuvimicrobium alcaliphilum 20Z

G4SW86

-

-

DELTA14-reductase

-

-

-

-

DELTA14-reductase

Sus scrofa

-

-

655352

ERG24

Aspergillus fumigatus

B0XMW7, B0XP65

-

763997

ERG24

Aspergillus fumigatus FGSC A1163

B0XMW7, B0XP65

-

-

ERG24

Candida albicans

-

-

723885

ERG24

Neurospora crassa

P38670

-

764764

ERG24

Neurospora crassa DSM 1257

P38670

-

-

ERG24

Saccharomyces cerevisiae

-

-

688770

ERG24

Saccharomyces cerevisiae

-

ERG24 represents C-14 reductase

288494

erg24A

Aspergillus fumigatus

B0XMW7

-

763997

erg24A

Aspergillus fumigatus FGSC A1163

B0XMW7

-

-

erg24B

Aspergillus fumigatus

B0XP65

-

763997

erg24B

Aspergillus fumigatus FGSC A1163

B0XP65

-

-

integral membrane sterol reductase

Methylotuvimicrobium alcaliphilum

G4SW86

-

745882

integral membrane sterol reductase

Methylotuvimicrobium alcaliphilum 20Z

G4SW86

-

-

LBR

Homo sapiens

-

-

672378

LBR

Homo sapiens

Q14739

-

765069

MaSR1

Methylotuvimicrobium alcaliphilum

G4SW86

-

745882

MaSR1

Methylotuvimicrobium alcaliphilum 20Z

G4SW86

-

-

sterol C-14 reductase

-

-

-

-

sterol C-14 reductase

Arabidopsis thaliana

-

-

657046

sterol C-14 reductase

Aspergillus fumigatus

B0XMW7, B0XP65

-

763997

sterol C-14 reductase

Aspergillus fumigatus FGSC A1163

B0XMW7, B0XP65

-

-

sterol C-14 reductase

Candida albicans

-

-

654204, 723885

sterol C-14 reductase

Fusarium graminearum

-

-

725903

sterol C-14 reductase

Homo sapiens

-

-

656304

sterol C-14 reductase

Neurospora crassa

-

-

656304, 656798

sterol C-14 reductase

Saccharomyces cerevisiae

-

-

688770

sterol DELTA14-reductase

-

-

-

-

sterol DELTA14-reductase

Oryctolagus cuniculus

-

-

713446

TM7SF2

Homo sapiens

O76062

-

765069

TM7SF2

Methylotuvimicrobium alcaliphilum

G4SW86

-

745882

TM7SF2

Methylotuvimicrobium alcaliphilum 20Z

G4SW86

-

-

TM7SF2

Mus musculus

Q71KT5

-

744648