1.3.1.70: DELTA14-sterol reductase
This is an abbreviated version!
For detailed information about DELTA14-sterol reductase, go to the full flat file.
Word Map on EC 1.3.1.70
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1.3.1.70
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lamins
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envelope
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chromatin
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heterochromatin
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nucleoplasm
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ergosterol
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lanosterol
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emerin
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lamina-associated
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greenberg
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laminopathies
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14alpha-demethylase
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fenpropimorph
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ff-mas
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chromatin-binding
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hypolobulated
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pharmacology
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pelger-huet
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agriculture
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analysis
- 1.3.1.70
- lamins
- envelope
- chromatin
- heterochromatin
- nucleoplasm
- ergosterol
- lanosterol
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emerin
-
lamina-associated
-
greenberg
- laminopathies
-
14alpha-demethylase
- fenpropimorph
-
ff-mas
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chromatin-binding
-
hypolobulated
- pharmacology
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pelger-huet
- agriculture
- analysis
Reaction
Synonyms
14-dehydrocholesterol reductase, 14-reductase, 14-SR, 3 beta-hydroxysterol-DELTA14-reductase, 3beta-hydroxysterol DELTA14-reductase, C-14 reductase, C-14 sterol reductase, C14-SR, C14-sterol reductase, C14SR, DELTA14-reductase, DELTA14-SR, DELTA14SR, DELTA7,14-steroid 14-reductase, DELTA7,14-sterol 14-reductase, DELTA7,14-sterol DELTA14-reductase, DELTA7,14-sterol-14-reductase, DELTA8,14-hydroxy steroid DELTA14(15)-reductase, DELTA8,14-steroid 14-reductase, DELTA8,14-sterol 14-reductase, DELTA8,14-sterol DELTA14-reductase, DELTA8,14-sterol-14-reductase, DHCR14, ERG 24, ERG24, erg24-1, erg24A, erg24B, fackel, FACKEL protein, FgERG24A, FgERG24B, FK, fk-J3158, integral membrane sterol reductase, lamin B receptor, lamin-B receptor, LBR, MaSR1, reductase, DELTA8,14-hydroxy steroid DELTA14(15)-, SR-1, sterol 14-reductase, sterol C-14 reductase, sterol C14-reductase, sterol DELTA14,15-reductase, sterol DELTA14-reductase, TM7SF2
ECTree
1.3.1.70 DELTA14-sterol reductaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 1.3.1.70 - DELTA14-sterol reductase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+
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presumably the natural substrate
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?
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + NADPH + H+
4alpha-methylfecosterol + NADP+
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step in the biosynthesis of the brassicasterol phytohormones, catalyzed by enzyme FK
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?
4alpha-methyl-8,14,24(28)-ergostatrien-3beta-ol + NADPH
4alpha-methyl-8,24(28)-ergostadien-3beta-ol + NADP+
5alpha-cholesta-8,14-dien-3beta-ol + NADPH
5alpha-cholesta-8-en-3beta-ol + NADP+
the substrate accumulates in patients suffering autosomal recessive HEM/Greenberg skeletal dysplasia
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?
follicular fluid meiosis-activating sterol + NADPH
testicular meiosis-activating sterol + NADP+
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?
isofucosterol + NADPH
sitosterol + NADP+
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step in the biosynthesis of the brassicasterol phytohormones, catalyzed by bifunctinal enzyme DIM1/CBB1/DWF1
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?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
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?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
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probably the natural substrate
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?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
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probably the natural substrate
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?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
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?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
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?
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
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?
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
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?
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
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?
4alpha-methyl-8,14,24(28)-ergostatrien-3beta-ol + NADPH
4alpha-methyl-8,24(28)-ergostadien-3beta-ol + NADP+
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4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol
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?
4alpha-methyl-8,14,24(28)-ergostatrien-3beta-ol + NADPH
4alpha-methyl-8,24(28)-ergostadien-3beta-ol + NADP+
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4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol
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?
additional information
?
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brassicasterols have regulatory function in the plants concerning growth and development, the enzyme is up-regulated by several growth-promoting hormones including brassinolide and auxin, overview
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?
additional information
?
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14-reductase has a important regulatory role in the overall cholesterol synthetic pathway
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?
additional information
?
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important essential enzyme of cholesterol biosynthesis from lanosterol
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?
additional information
?
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enzyme plays a key role in sterol biosynthesis, sterol content in vivo
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?
additional information
?
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enzyme involved in sterol, phytosterol, biosynthesis, DELTA8,14-sterols are intermediates in the biosynthesis of higher plant sterols, phytosterols
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?
additional information
?
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14-reductase has a important regulatory role in the overall cholesterol synthetic pathway
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?
additional information
?
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important essential enzyme of cholesterol biosynthesis from lanosterol
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?
additional information
?
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enzyme plays a key role in sterol biosynthesis, sterol content in vivo
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?
additional information
?
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enzyme-deficiency causes the lethal autosomal recessive HEM/Greenberg skeletal dysplasia, characterized by short limbs, fetal hydrops, abnormal chondro-osseous calcification
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?
additional information
?
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enzyme-deficiency causes the lethal autosomal recessive HEM/Greenberg skeletal dysplasia, characterized by short limbs, fetal hydrops, abnormal chondro-osseous calcification
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?
additional information
?
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enzyme-deficiency causes the lethal autosomal recessive HEM/Greenberg skeletal dysplasia, characterized by short limbs, fetal hydrops, abnormal chondro-osseous calcification
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?
additional information
?
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C14SR is encoded by the TM7SF2 gene. TM7SF2 but not LBR, gene expression is regulated by cell sterol levels in HepG2 (human) and H-35 (rat) hepatoma cells. Primary role of C14SR in human cholesterol biosynthesis
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?
additional information
?
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role of LBR in the cholesterol biosynthesis pathway is unclear
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?
additional information
?
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enzyme plays a key role in sterol biosynthesis
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?
additional information
?
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enzyme plays a key role in sterol biosynthesis, sterol content in vivo
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?
additional information
?
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catalyzes anaerobically NADPH-dependent reduction of 14-double bond of 8,14-diene or 7,14-diene sterols that are sterol intermediates formed during C-32 demethylation in cholesterol biosynthesis from lanosterol in mammals
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?
additional information
?
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catalyzes anaerobically NADPH-dependent reduction of 14-double bond of 8,14-diene or 7,14-diene sterols that are sterol intermediates formed during C-32 demethylation in cholesterol biosynthesis from lanosterol in mammals
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?
additional information
?
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reduction of 14-double bond of sterol-conjugated dienes
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?
additional information
?
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14-reductase has a important regulatory role in the overall cholesterol synthetic pathway
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?
additional information
?
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microsomal enzyme of cholesterol biosynthesis from lanosterol
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?
additional information
?
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important essential enzyme of cholesterol biosynthesis from lanosterol
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?
additional information
?
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reduction of DELTA8,14-intermediate in ergosterol biosynthetic pathway to DELTA8-intermediate occurs by the trans addition of two hydrogens to the 14alpha- and 15beta-positions
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?
additional information
?
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enzyme of biosynthetic pathways of ergosterol, major sterol in yeast, and cholesterol including a DELTA8,14-sterol intermediate as result of demethylation of lanosterol at C-14
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?
additional information
?
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essential enzyme of ergosterol, yeast sterol, biosynthesis from lanosterol
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?
additional information
?
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essential enzyme of ergosterol, yeast sterol, biosynthesis from lanosterol
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?
additional information
?
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reduction of DELTA8,14-intermediate in ergosterol biosynthetic pathway to DELTA8-intermediate occurs by the trans addition of two hydrogens to the 14alpha- and 15beta-positions
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?
additional information
?
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enzyme of biosynthetic pathways of ergosterol, major sterol in yeast, and cholesterol including a DELTA8,14-sterol intermediate as result of demethylation of lanosterol at C-14
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?
additional information
?
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essential enzyme of ergosterol, yeast sterol, biosynthesis from lanosterol
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?
additional information
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enzyme is involved in de novo synthesis of progesterone from lanosterol via cholesterol, pathway overview
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?
additional information
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DELTA8,14 derivatives are the only substrates to be transformed under normal biosynthetic conditions
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