1.3.1.6: fumarate reductase (NADH)
This is an abbreviated version!
For detailed information about fumarate reductase (NADH), go to the full flat file.
Word Map on EC 1.3.1.6
-
1.3.1.6
-
nitrate
-
malate
-
shewanella
-
fad
-
flavoproteins
-
fumarase
-
iron-sulfur
-
succinogenes
-
ascaris
-
flavocytochrome
-
helminth
-
oneidensis
-
wolinella
-
viologen
-
anthelmintic
-
frigidimarina
-
succinate-ubiquinone
-
tetraheme
-
menaquinol
-
narghji
-
thiabendazole
-
sdhcdab
-
c4-dicarboxylate
-
geobacter
-
flavinylation
-
succinate:quinone
-
dmsabc
-
hymenolepis
-
cyma
-
putrefaciens
-
medicine
-
drug development
- 1.3.1.6
- nitrate
- malate
- shewanella
- fad
- flavoproteins
- fumarase
-
iron-sulfur
- succinogenes
- ascaris
-
flavocytochrome
-
helminth
- oneidensis
-
wolinella
- viologen
-
anthelmintic
- frigidimarina
-
succinate-ubiquinone
-
tetraheme
- menaquinol
-
narghji
- thiabendazole
- sdhcdab
-
c4-dicarboxylate
- geobacter
-
flavinylation
-
succinate:quinone
- dmsabc
-
hymenolepis
-
cyma
- putrefaciens
- medicine
- drug development
Reaction
Synonyms
ABB37_00293, FRD, FRdABCD, FRDg, FRDm1, FRDm2, FRDS, Frds1p, fumarate reductase, KPA86010, KPK_2907, mitochondrial rhodoquinol-fumarate reductase, NADH-dependent fumarate reductase, NADH-FR, NADH-FRD, NADH-fumarate reductase, NFRD, QFR
ECTree
Advanced search results
Reference
Reference on EC 1.3.1.6 - fumarate reductase (NADH)
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Hopgood, M.F.; Walker, D.J.
Succinic acid production by rumen bacteria: III Enzymatic studies on the formation of succinate by Ruminococcus flavefaciens
Aust. J. Biol. Sci.
22
1413-1424
1969
Ruminococcus flavefaciens
Aue, B.J.; Deibel, R.H.
Fumarate reductase activity of Streptococcus faecalis
J. Bacteriol.
93
1770-1776
1967
Enterococcus faecalis
Dorn, M.; Andreesen, J.R.; Gottschalk, G.
Fumarate reductase of Clostridium formicoaceticum. A peripheral membrane protein
Arch. Microbiol.
119
7-11
1978
Clostridium formicaceticum
Hillier, A.J.; Jericho, R.E.; Green, S.M.; Jago, G.R.
Properties and function of fumarate reductase (NADH) in Streptococcus lactis
Aust. J. Biol. Sci.
32
625-635
1979
Enterococcus faecalis, Lactococcus lactis
Wetzstein, H.G.; Gottschalk, G.
A sodium-stimulated membrane-bound fumarate reductase system in Bacteroides amylophilus
Arch. Microbiol.
143
157-162
1985
Ruminobacter amylophilus
Meinhardt, S.W.; Glass, T.L.
Characterization of the NADH dehydrogenase and fumarate reductase of Fibrobacter succinogenes subsp. succinogenes S85
Arch. Microbiol.
162
329-334
1994
Fibrobacter succinogenes
-
Christmas, P.B.; Turrens, J.F.
Separation of NADH-fumarate reductase and succinate dehydrogenase activities in Trypanosoma cruzi
FEMS Microbiol. Lett.
183
225-228
2000
Trypanosoma cruzi
Chen, M.; Zhai, L.; Christensen, S.B.; Theander, T.G.; Kharazmi, A.
Inhibition of fumarate reductase in Leishmania major and L. donovani by chalcones
Antimicrob. Agents Chemother.
45
2023-2029
2001
Leishmania donovani, Leishmania major
Chen, M.; Bennedsen, M.; Zhai, L.; Kharazmi, A.
Purification and enzymatic activity of an NADH-fumarate reductase and other mitochondrial activities of Leishmania parasites
APMIS
109
801-808
2001
Leishmania donovani, Leishmania major
Besteiro, S.; Biran, M.; Biteau, N.; Coustou, V.; Baltz, T.; Canioni, P.; Bringaud, F.
Succinate secreted by Trypanosoma brucei is produced by a novel and unique glycosomal enzyme: NADH-dependent fumarate reductase
J. Biol. Chem.
22
38001-38012
2002
Trypanosoma brucei (Q8ITL2)
-
Pankhurst, K.L.; Mowat, C.G.; Miles, C.S.; Leys, D.; Walkinshaw, M.D.; Reid, G.A.; Chapman, S.K.
Role of His505 in the soluble fumarate reductase from Shewanella frigidimarina
Biochemistry
41
8551-8556
2002
Shewanella frigidimarina
Rothery, E.L.; Mowat, C.G.; Miles, C.S.; Walkinshaw, M.D.; Reid, G.A.; Chapman, S.K.
Histidine 61: an important heme ligand in the soluble fumarate reductase from Shewanella frigidimarina
Biochemistry
42
13160-13169
2003
Shewanella frigidimarina
Denicola, A.; Rubbo, H.; Haden, L.; Turrens, J.F.
Extramitochondrial localization of NADH-fumarate reductase in trypanosomatids
Comp. Biochem. Physiol. B
133
23-27
2002
Leishmania donovani, Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani S-2
Enomoto, K.; Arikawa, Y.; Muratsubaki, H.
Physiological role of soluble fumarate reductase in redox balancing during anaerobiosis in Saccharomyces cerevisiae
FEMS Microbiol. Lett.
215
103-108
2002
Saccharomyces cerevisiae
Coustou, V.; Besteiro, S.; Riviere, L.; Biran, M.; Biteau, N.; Franconi, J.M.; Boshart, M.; Baltz, T.; Bringaud, F.
A mitochondrial NADH-dependent fumarate reductase involved in the production of succinate excreted by procyclic Trypanosoma brucei
J. Biol. Chem.
280
16559-16570
2005
Trypanosoma brucei (Q5BU12), Trypanosoma brucei (Q5BU14), Trypanosoma brucei (Q8ITL2), Trypanosoma brucei
Baughn, A.D.; Malamy, M.H.
The essential role of fumarate reductase in haem-dependent growth stimulation of Bacteroides fragilis
Microbiology
149
1551-1558
2003
Bacteroides fragilis (Q7X478), Bacteroides fragilis (Q7X479), Bacteroides fragilis (Q7X480), Bacteroides fragilis
Kayser, O.; Chen, M.; Kharazmi, A.; Kiderlen, A.F.
Aurones interfere with Leishmania major mitochondrial fumarate reductase
Z. Naturforsch. C
57c
717-720
2002
Leishmania major
-
Hudson, J.M.; Heffron, K.; Kotlyar, V.; Sher, Y.; Maklashina, E.; Cecchini, G.; Armstrong, F.A.
Electron transfer and catalytic control by the iron-sulfur clusters in a respiratory enzyme, E. coli fumarate reductase
J. Am. Chem. Soc.
127
6977-6989
2005
Escherichia coli
Zaunmueller, T.; Kelly, D.J.; Gloeckner, F.O.; Unden, G.
Succinate dehydrogenase functioning by a reverse redox loop mechanism and fumarate reductase in sulphate-reducing bacteria
Microbiology
152
2443-2453
2006
Desulfovibrio desulfuricans
Matsumoto, J.; Sakamoto, K.; Shinjyo, N.; Kido, Y.; Yamamoto, N.; Yagi, K.; Miyoshi, H.; Nonaka, N.; Katakura, K.; Kita, K.; Oku, Y.
Anaerobic NADH-fumarate reductase system is predominant in the respiratory chain of Echinococcus multilocularis, providing a novel target for the chemotherapy of alveolar echinococcosis
Antimicrob. Agents Chemother.
52
164-170
2008
Echinococcus multilocularis, Echinococcus multilocularis Nemuro
Mercado-Lubo, R.; Gauger, E.J.; Leatham, M.P.; Conway, T.; Cohen, P.S.
A Salmonella enterica serovar typhimurium succinate dehydrogenase/fumarate reductase double mutant is avirulent and immunogenic in BALB/c mice
Infect. Immun.
76
1128-1134
2008
Salmonella enterica
Buettner, F.F.; Bendallah, I.M.; Bosse, J.T.; Dreckmann, K.; Nash, J.H.; Langford, P.R.; Gerlach, G.F.
Analysis of the Actinobacillus pleuropneumoniae ArcA regulon identifies fumarate reductase as a determinant of virulence
Infect. Immun.
76
2284-2295
2008
Actinobacillus pleuropneumoniae
Iwata, F.; Shinjyo, N.; Amino, H.; Sakamoto, K.; Islam, M.K.; Tsuji, N.; Kita, K.
Change of subunit composition of mitochondrial complex II (succinate-ubiquinone reductase/quinol-fumarate reductase) in Ascaris suum during the migration in the experimental host
Parasitol. Int.
57
54-61
2008
Ascaris suum
Shiomi, K.; Hatano, H.; Morimoto, H.; Ui, H.; Sakamoto, K.; Kita, K.; Tomoda, H.; Lee, E.W.; Heo, T.R.; Kawagishi, H.; Omura, S.
Decursin and decursinol angelate selectively inhibit NADH-fumarate reductase of Ascaris suum
Planta Med.
73
1478-1481
2007
Ascaris suum
Camarasa, C.; Faucet, V.; Dequin, S.
Role in anaerobiosis of the isoenzymes for Saccharomyces cerevisiae fumarate reductase encoded by OSM1 and FRDS1
Yeast
24
391-401
2007
Saccharomyces cerevisiae
Osanai, A.; Harada, S.; Sakamoto, K.; Shimizu, H.; Inaoka, D.K.; Kita, K.
Crystallization of mitochondrial rhodoquinol-fumarate reductase from the parasitic nematode Ascaris suum with the specific inhibitor flutolanil
Acta Crystallogr. Sect. F
65
941-944
2009
Ascaris suum
Pessanha, M.; Rothery, E.L.; Miles, C.S.; Reid, G.A.; Chapman, S.K.; Louro, R.O.; Turner, D.L.; Salgueiro, C.A.; Xavier, A.V.
Tuning of functional heme reduction potentials in Shewanella fumarate reductases
Biochim. Biophys. Acta
1787
113-120
2009
Shewanella oneidensis, Shewanella frigidimarina, Shewanella frigidimarina NCIMB400, Shewanella oneidensis MR-1 / ATCC 700550
Vieites, M.; Smircich, P.; Parajon-Costa, B.; Rodriguez, J.; Galaz, V.; Olea-Azar, C.; Otero, L.; Aguirre, G.; Cerecetto, H.; Gonzalez, M.; Gomez-Barrio, A.; Garat, B.; Gambino, D.
Potent in vitro anti-Trypanosoma cruzi activity of pyridine-2-thiol N-oxide metal complexes having an inhibitory effect on parasite-specific fumarate reductase
J. Biol. Inorg. Chem.
13
723-735
2008
Trypanosoma cruzi
Tomitsuka, E.; Kita, K.; Esumi, H.
The NADH-fumarate reductase system, a novel mitochondrial energy metabolism, is a new target for anticancer therapy in tumor microenvironments
Ann. N. Y. Acad. Sci.
1201
44-49
2010
Homo sapiens
Weingarten, R.A.; Taveirne, M.E.; Olson, J.W.
The dual-functioning fumarate reductase is the sole succinate:quinone reductase in Campylobacter jejuni and is required for full host colonization
J. Bacteriol.
191
5293-5300
2009
Campylobacter jejuni (Q0PBA0), Campylobacter jejuni (Q0PBA1), Campylobacter jejuni (Q0PBA2), Campylobacter jejuni, Campylobacter jejuni NCTC 11168 (Q0PBA0), Campylobacter jejuni NCTC 11168 (Q0PBA1), Campylobacter jejuni NCTC 11168 (Q0PBA2)
Tomitsuka, E.; Kita, K.; Esumi, H.
Regulation of succinate-ubiquinone reductase and fumarate reductase activities in human complex II by phosphorylation of its flavoprotein subunit
Proc. Jpn. Acad. Ser. B
85
258-265
2009
Homo sapiens
Tomitsuka, E.; Kita, K.; Esumi, H.
An anticancer agent, pyrvinium pamoate inhibits the NADH-fumarate reductase system - a unique mitochondrial energy metabolism in tumour microenvironments
J. Biochem.
152
171-183
2012
Homo sapiens
Edwards, C.; Copes, N.; Brito, A.; Canfield, J.; Bradshaw, P.
Malate and fumarate extend lifespan in Caenorhabditis elegans
PLoS ONE
8
e58345
2013
Caenorhabditis elegans
Mori, M.; Morimoto, H.; Kim, Y.; Ui, H.; Nonaka, K.; Masuma, R.; Sakamoto, K.; Kita, K.; Tomoda, H.; Shiomi, K.; Omura, S.
Ukulactones A and B, new NADH-fumarate reductase inhibitors produced by Penicillium sp. FKI-3389
Tetrahedron
67
6582-6586
2011
Ascaris suum
-
Yang, L.; Luebeck, M.; Ahring, B.K.; Luebeck, P.S.
Enhanced succinic acid production in Aspergillus saccharolyticus by heterologous expression of fumarate reductase from Trypanosoma brucei
Appl. Microbiol. Biotechnol.
100
1799-1809
2016
Trypanosoma brucei (Q8ITL2), Trypanosoma brucei
Liu, W.C.; Wang, Y.Y.; Liu, J.H.; Ke, A.B.; Zheng, Z.H.; Lu, X.H.; Luan, Y.S.; Xiu, Z.L.; Dong, Y.S.
Wortmannilactones I-L, new NADH-fumarate reductase inhibitors, induced by adding suberoylanilide hydroxamic acid to the culture medium of Talaromyces wortmannii
Bioorg. Med. Chem. Lett.
26
5328-5333
2016
Ascaris suum
Kaifuchi, S.; Mori, M.; Nonaka, K.; Masuma, R.; ?mura, S.; Shiomi, K.
Ukulactone C, a new NADH-fumarate reductase inhibitor produced by Talaromyces sp. FKI-6713
J. Gen. Appl. Microbiol.
61
57-62
2015
Ascaris suum
Salusjaervi, L.; Kaunisto, S.; Holmstroem, S.; Vehkomaeki, M.L.; Koivuranta, K.; Pitkaenen, J.P.; Ruohonen, L.
Overexpression of NADH-dependent fumarate reductase improves D-xylose fermentation in recombinant Saccharomyces cerevisiae
J. Ind. Microbiol. Biotechnol.
40
1383-1392
2013
Trypanosoma brucei (Q8ITL2), Trypanosoma brucei
Kim, S.H.; Mamuad, L.L.; Kim, D.W.; Kim, S.K.; Lee, S.S.
Fumarate reductase-producing Enterococci reduce methane production in rumen fermentation in vitro
J. Microbiol. Biotechnol.
26
558-566
2016
Enterococcus faecalis, Enterococcus faecalis SROD5, Enterococcus faecium, Enterococcus faecium SROD
Merlino, A.; Vieites, M.; Gambino, D.; Coitino, E.L.
Homology modeling of T. cruzi and L. major NADH-dependent fumarate reductases: ligand docking, molecular dynamics validation, and insights on their binding modes
J. Mol. Graph. Model.
48
47-59
2014
Leishmania major (E9AEQ8), Leishmania major, Trypanosoma cruzi (Q4CYX1), Trypanosoma cruzi, Trypanosoma cruzi CL Brener (Q4CYX1)
Serebryakova, M.V.; Bertsova, Y.V.; Sokolov, S.S.; Kolesnikov, A.A.; Baykov, A.A.; Bogachev, A.V.
Catalytically important flavin linked through a phosphoester bond in a eukaryotic fumarate reductase
Biochimie
149
34-40
2018
Leptomonas pyrrhocoris (A0A0N0E041), Leptomonas pyrrhocoris
html completed