1.3.1.6: fumarate reductase (NADH)
This is an abbreviated version!
For detailed information about fumarate reductase (NADH), go to the full flat file.
Word Map on EC 1.3.1.6
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1.3.1.6
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nitrate
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malate
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shewanella
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fad
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flavoproteins
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fumarase
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iron-sulfur
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succinogenes
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ascaris
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flavocytochrome
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helminth
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oneidensis
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wolinella
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viologen
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anthelmintic
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frigidimarina
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succinate-ubiquinone
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tetraheme
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menaquinol
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narghji
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thiabendazole
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sdhcdab
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c4-dicarboxylate
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geobacter
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flavinylation
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succinate:quinone
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dmsabc
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hymenolepis
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cyma
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putrefaciens
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medicine
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drug development
- 1.3.1.6
- nitrate
- malate
- shewanella
- fad
- flavoproteins
- fumarase
-
iron-sulfur
- succinogenes
- ascaris
-
flavocytochrome
-
helminth
- oneidensis
-
wolinella
- viologen
-
anthelmintic
- frigidimarina
-
succinate-ubiquinone
-
tetraheme
- menaquinol
-
narghji
- thiabendazole
- sdhcdab
-
c4-dicarboxylate
- geobacter
-
flavinylation
-
succinate:quinone
- dmsabc
-
hymenolepis
-
cyma
- putrefaciens
- medicine
- drug development
Reaction
Synonyms
ABB37_00293, FRD, FRdABCD, FRDg, FRDm1, FRDm2, FRDS, Frds1p, fumarate reductase, KPA86010, KPK_2907, mitochondrial rhodoquinol-fumarate reductase, NADH-dependent fumarate reductase, NADH-FR, NADH-FRD, NADH-fumarate reductase, NFRD, QFR
ECTree
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Inhibitors
Inhibitors on EC 1.3.1.6 - fumarate reductase (NADH)
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4,6,3'-hydroxy-4'-methoxy-2-[phenylhydroxymethylene]-3(2H)-benzofuran-3-one
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4,6,4'-hydroxy-3'-methoxy-2-[phenylhydroxymethylene]-3(2H)-benzofuran-3-one
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4,6,4'-triacetyl-3',5'-dimethoxy-2-[phenylhydroxymethylene]-3(2H)-benzofuran-3-one
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i.e. bracteintriacetate
6-hydroxy-2-[(2,3,4-trihydroxyphenyl)-methylene]-3(2H)-benzofuran-3-one-5-beta-D-glucopyranoside
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i.e. bractein
6-hydroxy-3',4'-dimethoxy-2-[phenylhydroxymethylene]-3(2H)-benzofuran-3-one
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ClHgSO3H
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inhibition with all cofactors except the methyl viologen dependent activity
KCN
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inhibition with all cofactors except the methyl viologen dependent activity
N-(4-[[2-(4-tert-butylphenyl)ethyl]amino]phthalazin-6-yl)prop-2-enamide
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N-[2-(4-tert-butylphenyl)ethyl]-5-(1-methylethoxy)phthalazin-1-amine
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Pd-(pyridine-2-thiol N-oxide)2
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inhibitory effect of metal-pyridine-2-thiol N-oxide complexes, marked increase is obeserved in the inhibitory effect with respect to that of the free ligand, inhibition in a dose-dependent manner, a clear relief of the growth inhibition produced by the metal-mpo complex is observed in the presence of 5 mM succinate
Pt-(pyridine-2-thiol N-oxide)2
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inhibitory effect of metal-pyridine-2-thiol N-oxide complexes, inhibition observed 2 is similar to that obtained with the ligand alone, a clear relief of the growth inhibition produced by the metal-mpo complex is observed in the presence of 5 mM succinate
pyridine-2-thiol N-oxide
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2-mercaptopyridine N-oxide (mpo) is a bioactive ligand with a potential as antitrypanosomal agent
Triton X-100
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complete loss of NADH dependent activity at concentration of 0.05%, up to 17fold increase in methyl viologen dependent activity
pyrvinium pamoate
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an anthelmintic drug, has an anticancer effect within tumor-mimicking microenvironments, biological mechanism of pyrvinium is the inhibition of the NADH-fumarate reductase system. Under normal conditions, pyrvinium pamoate activates complex II activity and inhibits complex I activity. Pyrvinium pamoate activates the mitochondrial respiratory chain via complex II, despite inhibiting complex I. In cancer cells under hypoxic and glucose-deprived conditions, the activation of SQR by pyrvinium pamoate disappeared and NADH-fumarate reductase activity is inhibited. Pyrvinium pamoate becomes cytotoxic to cancer cells under tumor microenvironmental conditions
pyrvinium pamoate
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anthelmintic, has an anti-cancer effect within tumour-mimicking microenvironments. Pyrvinium pamoate inhibits NADH-fumarate reductase activities in both parasites and mammalian mitochondria and increases the activity of complex II, succinate-ubiquinone reductase, which is part of fumarate reductase, in mitochondria from human cancer cells cultured under normoxia-normoglycemic conditions but not under hypoxia-hypoglycemic conditions
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polyketide isolated from a culture broth of Penicillium sp. FKI-3389, shows potent inhibitory activity
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polyketide isolated from a culture broth of Penicillium sp. FKI-3389. Inhibitory activity is 200 times weaker than that of epimer ukulactone A
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inhibitory potency of aurones and auronols, overview
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additional information
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inactivation by irradiation at 254 nm, can be partially restored by addition of 2,3-dimethyl-1,4-naphthoquinone
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