1.3.1.48: 13,14-dehydro-15-oxoprostaglandin 13-reductase

This is an abbreviated version!
For detailed information about 13,14-dehydro-15-oxoprostaglandin 13-reductase, go to the full flat file.

Word Map on EC 1.3.1.48

1.3.1.48

eicosanoids

15-hydroxyprostaglandins

15-pgdh

cyclooxygenases

acylfulvene

Reaction

(13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate

Synonyms

15-hydroxyprostaglandin dehydrogenase, 15-keto-PG reductase, 15-ketoprostaglandin DELTA-13-reductase, 15-ketoprostaglandin DELTA13-reductase, 15-ketoprostaglandinDELTA13-reductase, 15-oxoprostaglandin 13-oxidase, 15-oxoprostaglandin 13-reductase, 15-oxoprostaglandin DELTA13-reductase, 15-oxoprostaglandin-DELTA13-reductase, 15-PGDH, Ad-PGR, bifunctional leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, bifunctional LTB4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, DELTA13-15-ketoprostaglandin reductase, leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin 13-reductase, leukotriene B4 dehydrogenase, leukotriene B4-12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, LTB4 12-HD/PGR, LTBDH/PGR, NAD(P)H-dependent alkenal/one oxidoreductase, PG reductase, PGR, PGR-2, PGR1, prostaglandin 13-reductase, prostaglandin DELTA13-reductase, prostaglandin reductase 1, reductase, 15-oxo-DELTA13-prostaglandin

ECTree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.1.48 13,14-dehydro-15-oxoprostaglandin 13-reductase

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Results	in table
2927	AA Sequence
1	CAS Registry Number
9	Cloned(Commentary)
21	Cofactor
3	Crystallization (Commentary)
35	Disease/ Diagnostics
3	General Information
22	IC50 Value
55	Inhibitors
5	Ki Value [mM]
72	KM Value [mM]
3	Localization
1	Metals/Ions
9	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
21	Organism
6	Pathway
22	PDB ID
3	pH Optimum
2	pH Range
13	Purification (Commentary)
1	Reaction
4	Reaction Type
21	Reference
31	Source Tissue
22	Specific Activity [micromol/min/mg]
8	Storage Stability
123	Substrates and Products (Substrate)
3	Subunits
31	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
28	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.3.1.48 - 13,14-dehydro-15-oxoprostaglandin 13-reductase

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11alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+

(13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate + NAD(P)H + H+

Homo sapiens

P15428

744677

15-ketoprostaglandin E + NAD(P)H

3 entries

15-oxoprostaglandin F1alpha + NAD(P)H

3 entries

prostaglandin E2 + NADP+

15-ketoprostaglandin E2 + NADPH + H+

Homo sapiens

746356

additional information

2 entries