1.3.1.24: biliverdin reductase
This is an abbreviated version!
For detailed information about biliverdin reductase, go to the full flat file.
Word Map on EC 1.3.1.24
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1.3.1.24
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heme
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oxygenase-1
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monoxide
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cytoprotective
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repolarization
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beat-to-beat
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rosenthal
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hyperbilirubinemia
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palliation
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tetrapyrrole
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tdp
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torsades
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diagnostics
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proarrhythmia
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medicine
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galenic
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univentricular
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pharmacology
- 1.3.1.24
- heme
- oxygenase-1
-
monoxide
-
cytoprotective
-
repolarization
-
beat-to-beat
-
rosenthal
-
hyperbilirubinemia
-
palliation
- tetrapyrrole
- tdp
-
torsades
- diagnostics
-
proarrhythmia
- medicine
-
galenic
-
univentricular
- pharmacology
Reaction
Synonyms
biliverdin IXalpha reductase, biliverdin IXbeta reductase, biliverdin reductase, biliverdin reductase A, biliverdin reductase B, Biliverdin reductase-A, biliverdin-IXalpha reductase, BLVR subtype B, BLVRA, BLVRB, BV reductase, BVR, BVR-A, BVR-B, BVRA, BVRB, F-BVR, F420H2-dependent biliverdin reductase, hBVR, hBVR-A, reductase, biliverdin, Rv2074, slr1784
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Reaction
Reaction on EC 1.3.1.24 - biliverdin reductase
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bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+
catalysis via hydride transfer from NADH
bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+
induced fit docking is emplyed to study the substrate binding modes to hBVR-A of biliverdin-IXalpha and four analogues. Substrate binding modes are examined further by performing molecular dynamics (MD) simulations followed by molecular mechanics Poisson-Boltzmann surface area (MM-PBSA) calculations. On the basis of our calculations, the energetically preferred pathway consists of an initial protonation of the pyrrolic nitrogen on the biliverdin substrate followed by hydride transfer to yield the reduction product
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