1.3.1.22: 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.3.1.22

1.3.1.22

androgen

prostate

dihydrotestosterone

srd5a2

finasteride

genitalia

5alpha-reduced

hypospadias

3alpha-hydroxysteroid

pseudohermaphroditism

5alpha-r1

medicine

5alpha-reduction

17beta-hsds

1.3.99.5

hirsutism

17beta-hydroxysteroid

virilization

pharmacology

analysis

Reaction

Synonyms

3-oxosteroid 5alpha-reductase, 3-oxosteroid DELTA4-dehydrogenase, 4-ene-3-oxosteroid 5alpha-reductase, 4-ene-5alpha-reductase, 5 alpha-R2, 5 alpha-reductase type 2, 5-alpha reductase I, 5-alpha reductase II, 5-alpha-reductase type 1, 5-alpha-reductase type 2, 5a-reductase type 1, 5a-reductase type 2, 5A2, 5alpha-R1, 5alpha-R2, 5alpha-reductase 1, 5alpha-reductase II, 5alpha-reductase type 1, 5alpha-reductase type 2, 5alpha-reductase type II, 5alpha-SR2, 5alphaR, 5alphaR type 2, 5alphaR1, 5alphaR2, AtDET2, brainneurosteroidogenic 5x02-reductase 1, cholest-4-en-3-one 5alpha-reductase, cortisone alpha-reductase, cortisone DELTA 4-5alphareductase, DCC71_03205, DELTA4-3-ketosteroid 5alpha-oxidoreductase, DELTA4-3-ketosteroid reductase (5alpha), DELTA4-3-oxosteroid-5 alpha-reductase, DELTA4-5alpha-reductase, DELTA4-steroid 5alpha-reductase (progesterone), EC 1.3.1.30, EC 1.3.1.4, LeDET2, microsomal steroid reductase (5alpha), More, NADPH:DELTA4-3-oxosteroid-5alpha-oxidoreductase, neurosteroidogenic 5alpha-reductase 1, progesterone 5alpha-reductase, reduced nicotinamide adenine dinucleotide phosphate:DELTA4-3-ketosteroid 5alpha-oxidoreductase, reductase, cholestenone 5alpha-, reductase, cortisone DELTA: 4-5alpha-, reductase, progesterone 5alpha-, S5alphaR, SRD5A1, SRD5A2, SRDA1, SRDA2, SRDA3, steroid 5-alpha reductase, steroid 5-alpha-reductase, steroid 5alpha reductase type 2, steroid 5alpha-hydrogenase, steroid 5alpha-reductase, steroid 5alpha-reductase type II, testosterone 5alpha-reductase, testosterone delta4-5alpha-reductase, testosterone delta4-hydrogenase, type 1 5alpha-reductase, type 1 5alphaR, type 1 SR, type 1 steroid 5alpha reductase, type 1 steroid 5alpha-reductase, type 2 5alpha-reductase, type 2 5alphaR, type 2 SR, type 2 steroid 5alpha reductase, type 2 steroid 5alpha-reductase, type II 5alpha-reductase, type-1 5alpha-reductase, type-2 5alpha-reductase

ECTree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.1.22 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
19	Activating Compound
2076	AA Sequence
14	Application
3	CAS Registry Number
13	Cloned(Commentary)
96	Cofactor
3	Crystallization (Commentary)
278	Disease/ Diagnostics
4	Expression
3	General Information
4	General Stability
61	IC50 Value
447	Inhibitors
80	Ki Value [mM]
98	KM Value [mM]
56	Localization
6	Metals/Ions
7	Molecular Weight [Da]
26	Natural Substrates/ Products (Substrates)
158	Organism
13	Pathway
1	PDB ID
38	pH Optimum
9	pH Range
2	pH Stability
41	Protein Variants
6	Purification (Commentary)
8	Reaction
3	Reaction Type
154	Reference
1	Renatured (Commentary)
169	Source Tissue
14	Specific Activity [micromol/min/mg]
4	Storage Stability
172	Substrates and Products (Substrate)
4	Subunits
134	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
3	Temperature Range [°C]
3	Temperature Stability [°C]

pH Optimum

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

pH Optimum on EC 1.3.1.22 - 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to pH Optimum Search

5.2 - 5.6

mutant G34R

5.5

5.5 - 7.5

5.7

in testis microsomes of 5 month-old animals

5.8 - 7.5

6 - 6.5

mutant P181L

6 - 7.2

6.2

female

6.3

in testis microsomes of 6 month-old animals

6.5

6.6

6.9

7 - 8

7 - 9

human: 2 forms, 1. pH-optimum 5.5 (only in fibroblasts derived from genital skin), 2. pH-optimum 7-9 (in both genital and nongenital skin regions and in fibroblast from all skin regions)

7.2

7.3 - 7.6

7.4

7.5

recombinant monkey 5alpha-reductase isozyme 1

396219