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BRENDA support

1.3.1.21: 7-dehydrocholesterol reductase

This is an abbreviated version!
For detailed information about 7-dehydrocholesterol reductase, go to the full flat file.

Word Map on EC 1.3.1.21

Reaction

cholesterol
+
NADP+
=
cholesta-5,7-dien-3beta-ol
+
NADPH
+
H+

Synonyms

3-hydroxysterol DELTA7-reductase, 3beta-hydroxysterol DELTA7-reductase, 3beta-hydroxysterol-DELTA7-reductase, 7-dehydrocholesterol DELTA7 reductase, 7-dehydrocholesterol DELTA7-reductase, 7-DHC reductase, 7-DHCR, Csa7G447780, DAF-36, DELTA5,7-sterol DELTA7-reductase, Des7, Dhcr7, Dhcr7-AS-1, Dhcr7-AS-2, Dhcr7-AS-4, Dwarf5 protein, DWF5, Neverland, Nvd, reductase, 7-dehydrocholesterol, Sterol delta-7-reductase, sterol DELTA7 reductase, sterol DELTA7-reductase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.21 7-dehydrocholesterol reductase

Source Tissue

Source Tissue on EC 1.3.1.21 - 7-dehydrocholesterol reductase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
of healthy persons, heterozygous persons, and Smith-Lemli-Opitz syndrome patients
Manually annotated by BRENDA team
-
exocrine, high desmosterol synthesis
Manually annotated by BRENDA team
-
of healthy persons, heterozygous persons, and Smith-Lemli-Opitz syndrome patients
Manually annotated by BRENDA team
-
coexpression of enzyme and Sonic Hedgehog, Shh, during midline development in embryo. Enzyme functions as an negative regulator in Hedghog signaling at the level or downstream of Smoothend and affects intracellular Hedgehog signaling
Manually annotated by BRENDA team
with holoprosencephaly at gestation age of 21 to 33 weeks
Manually annotated by BRENDA team
-
human epidermal keratinocyte
Manually annotated by BRENDA team
-
progenitor cells, immature cells, and adult cells, differentially expressed transcripts and enzyme expression levels during development and differentiation, overview
Manually annotated by BRENDA team
-
15-20% of total activiy in brain, lipid exchange between microsomes and myelin
Manually annotated by BRENDA team
-
during early embryonic development, the expression of Xdhcr7 is first of all spatially restricted to the Spemann’s organizer and later to the notochord. In both tissues, Xdhcr7 is coexpressed with Sonic hedgehog, Shh
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
during early embryonic development, the expression of Xdhcr7 is first of all spatially restricted to the Spemann’s organizer and later to the notochord. In both tissues, Xdhcr7 is coexpressed with Sonic hedgehog, Shh
Manually annotated by BRENDA team
-
low activity
Manually annotated by BRENDA team
additional information