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1.3.1.20: trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

This is an abbreviated version!
For detailed information about trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, go to the full flat file.

Word Map on EC 1.3.1.20

Reaction

trans-1,2-Dihydrobenzene-1,2-diol
+
NADP+
=
catechol
 +
NADPH
 +
H+

Synonyms

AKR1C1, AKR1C2, DD, DDH, DDH1, DDH2, dehydrogenase, trans-1,2-dihydrobenzene-1,2-diol, DHDH, dihydrodiol dehydrogenase, More

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

Specific Activity

Specific Activity on EC 1.3.1.20 - trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0067
-
pH 7.4, cytosolic fraction of parental 2008 cell
0.011
-
extract, substrate naphthalene dihydrodiol
0.0213
-
pH 7.4, cytosolic fraction of 2008 cell expressing isoform 2
0.024
-
extract, substrate naphthalene dihydrodiol
0.0263
-
pH 7.4, cytosolic fraction of 2008 cell expressing isoform 1
0.0328
-
pH 7.4, cytosolic fraction of 2008/C13* cell
0.038
-
extract, substrate naphthalene dihydrodiol
0.04
R148A and R202A mutant, 25 mM Tris-HCl, pH 7.5, 0.25 mM NADP+
0.05
wild type enzyme in dimeric form, 25 mM Tris-HCl, pH 7.5, 0.25 mM NADP+
0.11 - 0.12
-
pH 10.0, kidney cortex, substrate trans-benzene dihydrodiol
0.21
DD4, substrate androsterone
0.73
-
DD4 recombinant double mutant S145C/L311V, purified, substrate (S)-indan-1-ol
1.2
monomeric form
1.5
-
DD4 recombinant mutant S145C, purified, substrate (S)-indan-1-ol
2.1
recombinant DD1, substrate 1-acenaphthenol
2.23
-
recombinant DD4, substrate (S)-indan-1-ol
2.5
recombinant DD2, substrate 1-acenaphthenol
2.8
recombinant 3alpha-hydroxysteroid/dihydrodiol dehydrogenase
2000
-
substrate 1-indanol, 2008 cells constitutively overexpressing enzyme
26000
-
substrate 1-acenaphthol, 2008 cells constitutively overexpressing enzyme
33000
-
substrate 1-acenaphthol, 2008/C13* cells
35000
-
substrate camphorquinone, 2008 cells
5.525
-
purified enzyme
5.65
-
purified enzyme
500
-
substrate 1-indanol, 2008 cells
6000
-
substrate 1-indanol, 2008/C13* cells
65000
-
substrate camphorquinone, 2008/C13* cells
7.3
-
co-purified enzyme, D-xylose dehydrogenase activity
7000
-
substrate 1-acenaphthol, 2008 cells
71000
-
substrate camphorquinone, 2008 cells constitutively overexpressing enzyme
8
-
co-purified enzyme, dihydrodiol dehydrogenase activity
additional information