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1.3.1.20: trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

This is an abbreviated version!
For detailed information about trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, go to the full flat file.

Word Map on EC 1.3.1.20

Reaction

trans-1,2-Dihydrobenzene-1,2-diol
+
NADP+
=
catechol
+
NADPH
+
H+

Synonyms

AKR1C1, AKR1C2, DD, DDH, DDH1, DDH2, dehydrogenase, trans-1,2-dihydrobenzene-1,2-diol, DHDH, dihydrodiol dehydrogenase, More

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

Reference

Reference on EC 1.3.1.20 - trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Asada, Y.; Aoki, S.; Ishikura, S.; Usami, N.; Hara, A.
Roles of His-79 and Tyr-180 of D-xylose/dihydrodiol dehydrogenase in catalytic function
Biochem. Biophys. Res. Commun.
278
333-337
2000
Macaca fuscata
Manually annotated by BRENDA team
Aoki, S.; Ishikura, S.; Asada, Y.; Usami, N.; Hara, A.
Identity of dimeric dihydrodiol dehydrogenase as NADP+-dependent D-xylose dehydrogenase in pig liver
Chem. Biol. Interact.
130-132
775-784
2001
Canis sp., Oryctolagus cuniculus, Homo sapiens, Macaca fuscata, Sus scrofa
Manually annotated by BRENDA team
Nakagawa, M.; Matsuura, K.; Hara, A.; Sawada, H.; Bunai, H.; Ohya, I.
Dimeric dihydrodiol dehydrogenase in monkey kidney. Substrate specificity, stereospecificity of hydrogen transfer, and distribution
J. Biochem.
106
1104-1109
1989
Macaca fascicularis, Macaca fuscata
Manually annotated by BRENDA team
Penning, T.M.; Sharp, R.B.; Smithgall, T.E.
Non-K-region o-quinones as enzyme-generated inactivators of dihydrodiol dehydrogenase
Biochemistry
28
4505-4511
1989
Rattus norvegicus
Manually annotated by BRENDA team
Nakagawa, M.; Tsukada, F.; Nakayama, T.; Matsuura, K.; Hara, A.; Sawada, H.
Identification of two dihydrodiol dehydrogenases associated with 3(17)alpha-hydroxysteroid dehydrogenase activity in mouse kidney
Biochem. J.
106(4)
633-638
1989
Mus musculus
Manually annotated by BRENDA team
Hara, A.; Harada, T.; Nakagawa, M.; Matsuura, K.; Nakayama, T.; Sawada, H.
Isolation from pig lens of two proteins with dihydrodiol dehydrogenase and aldehyde reductase activities
Biochem. J.
264
403-407
1989
Sus scrofa
Manually annotated by BRENDA team
Smithgall, T.E.; Harvey, R.G.; Penning, T.M.
Spectroscopic identification of ortho-quinones as the products of polycyclic aromatic trans-dihydrodiol oxidation catalyzed by dihydrodiol dehydrogenase. A potential route of proximate carcinogen metabolism
J. Biol. Chem.
263
1814-1820
1988
Rattus norvegicus
Manually annotated by BRENDA team
Hara, A.; Mouri, K.; Sawada, H.
Purification and partial characterization of dimeric dihydrodiol dehydrogenase from monkey kidney
Biochem. Biophys. Res. Commun.
145
1260-1266
1987
Macaca fuscata
Manually annotated by BRENDA team
Matsuura, K.; Hara, A.; Nakayama, T.; Nakagawa, M.; Sawada, H.
Purification and properties of two multiple forms of dihydrodiol dehydrogenase from guinea-pig testis
Biochim. Biophys. Acta
912
270-277
1987
Cavia porcellus
Manually annotated by BRENDA team
Smithgall, T.E.; Harvey, R.G.; Penning, T.M.
Regio- and stereospecificity of homogeneous 3alpha-hydroxysteroid-dihydrodiol dehydrogenase for trans-dihydrodiol metabolites of polycyclic aromatic hydrocarbons
J. Biol. Chem.
261
6184-6191
1986
Rattus norvegicus
Manually annotated by BRENDA team
Boutin, J.A.; Shikita, M.; Talalay, P.
Rat liver microsomal 3alpha-hydroxysteroid dehydrogenase and dihydrodiol dehydrogenase: solubilization, separation and partial purification
Biochem. Biophys. Res. Commun.
135
795-801
1986
Rattus norvegicus
Manually annotated by BRENDA team
Bolcsak, L.E.; Nerland, D.E.
Purification of mouse liver benzene dihydrodiol dehydrogenases
J. Biol. Chem.
258
7252-7255
1983
Mus musculus
Manually annotated by BRENDA team
Vogel, K.; Bentley, P.; Platt, K.L.; Oesch, F.
Rat liver cytoplasmic dihydrodiol dehydrogenase. Purification to apparent homogeneity and properties
J. Biol. Chem.
255
9621-9625
1980
Rattus norvegicus
Manually annotated by BRENDA team
Terada, T.; Fujita, N.; Sugihara, Y.; Sato, R.; Takagi, T.; Maeda, M.
Site-directed mutagenesis studies of bovine liver cytosolic dihydrodiol dehydrogenase: the role of Asp-50, Tyr-55, Lys-84, His-117, Cys-145 and Cys-193 in enzymatic activity
Chem. Biol. Interact.
130-132
833-845
2001
Bos taurus
Manually annotated by BRENDA team
Nanjo, H.; Nishinaka, T.; Nagai, M.; Terada, T.; Mizoguchi, T.; Nishihara, T.
Unique dihydrodiol specific dehydrogenase of bovine liver: Inhibition studies and comparison with aldo/keto reductase
Adv. Exp. Med. Biol.
328
371-377
1993
Bos taurus
Manually annotated by BRENDA team
Kume, T.; Iwasa, H.; Shiraishi, H.; Yokoi, T.; Nagashima, K.; Otsuka, M.; Terada, T.; Takagi, T.; Hara, A.; Kamataki, T.
Characterization of a novel variant (S145C/L311V) of 3alpha-hydroxysteroid/dihydrodiol dehydrogenase in human liver
Pharmacogenetics
9
763-771
1999
Homo sapiens
Manually annotated by BRENDA team
Miyabe, Y.; Amano, T.; Deyashiki, Y.; Hara, A.; Tsukada, F.
Kinetic studies of the inhibition of a human liver 3alpha-hydroxysteroid/dihydrodiol dehydrogenase isozyme by bile acids and anti-inflammatory drugs
Biol. Pharm. Bull.
18
9-12
1995
Homo sapiens
Manually annotated by BRENDA team
Sato, K.; Nakanishi, M.; Deyashiki, Y.; Hara, A.; Matsuura, K.; Ohya, I.
Purification and characterization of dimeric dihydrodiol dehydrogenase from dog liver
J. Biochem.
116
711-717
1994
Canis sp.
Manually annotated by BRENDA team
Deyashiki, Y.; Tamada, Y.; Miyabe, Y.; Nakanishi, M.; Matsuura, K.; Hara, A.
Expression and kinetic properties of a recombinant 3alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzyme of human liver
J. Biochem.
118
285-290
1995
Homo sapiens
Manually annotated by BRENDA team
Nanjo, H.; Adachi, H.; Morihana, S.; Mizoguchi, T.; Nishihara, T.; Terada, T.
Enzymic characterization of a novel bovine liver dihydrodiol dehydrogenase - reaction mechanism and bile acid dehydrogenase activity
Biochim. Biophys. Acta
1244
53-61
1995
Bos taurus
Manually annotated by BRENDA team
Hoog, S.S.; Pawlowski, J.E.; Alzari, P.M.; Penning, T.M.; Lewis, M.
Three-dimensional structure of rat liver 3.alpha-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamily
Proc. Natl. Acad. Sci. USA
91
2517-2521
1994
Rattus norvegicus
Manually annotated by BRENDA team
El-Kabbani, O.; Chung, R.P.T.; Ramsland, P.A.; Asada, Y.; Ishikura, S.; Usami, N.; Hara, A.
Crystallization and preliminary x-ray diffraction analysis of monkey dimeric dihydrodiol dehydrogenase
Acta Crystallogr. Sect. D
58
163-164
2002
Macaca fuscata
Manually annotated by BRENDA team
Hara, A.; Matsuura, K.; Tamada, Y.; Sato, K.; Miyabe, Y.; Deyashiki, Y.; Ishida, N.
Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells
Biochem. J.
313
373-376
1996
Homo sapiens (Q04828)
Manually annotated by BRENDA team
Burczynski, M.E.; Harvey, R.G.; Penning, T.M.
Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to the activated o-quinone metabolite benzo[a]pyrene-7,8-dione
Biochemistry
37
6781-6790
1998
Homo sapiens (P42330)
Manually annotated by BRENDA team
Matsuura, K.; Hara, A.; Deyashiki, Y.; Iwasa, H.; Kume, T.; Ishikura, S.; Shiraishi, H.; Katagiri, Y.
Roles of the C-terminal domains of human dihydrodiol dehydrogenase isoforms in the binding of substrates and modulators: probing with chimeric enzymes
Biochem. J.
336
429-436
1998
Homo sapiens
Manually annotated by BRENDA team
Matsuura, K.; Deyashiki, Y.; Sato, K.; Ishida, N.; Miwa, G.; Hara, A.
Identification of amino acid residues responsible for differences in substrate specificity and inhibitor sensitivity between two human liver dihydrodiol dehydrogenase isoenzymes by site-directed mutagenesis
Biochem. J.
323
61-64
1997
Homo sapiens
Manually annotated by BRENDA team
Bennett, M.J.; Albert, R.H.; Jez, J.M.; Ma, H.; Penning, T.M.; Lewis, M.
Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3alpha-hydroxysteroid/dihydrodiol dehydrogenase
Structure
5
799-812
1997
Rattus norvegicus
Manually annotated by BRENDA team
Deng, H.B.; Adikari, M.; Parekh, H.K.; Simpkins, H.
Ubiquitous induction of resistance to platinum drugs in human ovarian, cervical, germ-cell and lung carcinoma tumor cells overexpressing isoforms 1 and 2 of dihydrodiol dehydrogenase
Cancer Chemother. Pharmacol.
54
301-307
2004
Homo sapiens
Manually annotated by BRENDA team
Seike, K.; Murata, M.; Hirakawa, K.; Deyashiki, Y.; Kawanishi, S.
Oxidative DNA damage induced by benz[a]anthracene dihydrodiols in the presence of dihydrodiol dehydrogenase
Chem. Res. Toxicol.
17
1445-1451
2004
Mus musculus
Manually annotated by BRENDA team
Higaki, Y.; Kamiya, T.; Usami, N.; Shintani, S.; Shiraishi, H.; Ishikura, S.; Yamamoto, I.; Hara, A.
Molecular characterization of two monkey dihydrodiol dehydrogenases
Drug Metab. Pharmacokinet.
17
348-356
2002
Macaca fuscata fuscata (Q95JH4), Macaca fuscata fuscata (Q95JH6), Macaca fascicularis (Q95JH5), Macaca fascicularis (Q95JH7)
Manually annotated by BRENDA team
Wang, L.S.; Chow, K.C.; Wu, Y.C.; Lin, T.Y.; Li, W.Y.
Inverse expression of dihydrodiol dehydrogenase and glutathione-S-transferase in patients with esophageal squamous cell carcinoma
Int. J. Cancer
111
246-251
2004
Homo sapiens
Manually annotated by BRENDA team
Deng, H.B.; Parekh, H.K.; Chow, K.C.; Simpkins, H.
Increased expression of dihydrodiol dehydrogenase induces resistance to cisplatin in human ovarian carcinoma cells
J. Biol. Chem.
277
15035-15043
2002
Homo sapiens
Manually annotated by BRENDA team
Yang, M.D.; Wu, C.C.; Chiou, S.H.; Chiu, C.F.; Lin, T.Y.; Chiang, I.P.; Chow, K.C.
Reduction of dihydrodiol dehydrogenase expression in resected hepatocellular carcinoma
Oncol. Rep.
10
271-276
2003
Homo sapiens
Manually annotated by BRENDA team
Tang, D.W.; Chang, K.W.; Chi, C.W.; Liu, T.Y.
Hydroxychavicol modulates benzo[a]pyrene-induced genotoxicity through induction of dihydrodiol dehydrogenase
Toxicol. Lett.
152
235-243
2004
Homo sapiens
Manually annotated by BRENDA team
Hung, J.J.; Chow, K.C.; Wang, H.W.; Wang, L.S.
Expression of dihydrodiol dehydrogenase and resistance to chemotherapy and radiotherapy in adenocarcinoma cells of lung
Anticancer Res.
26
2949-2956
2006
Homo sapiens
Manually annotated by BRENDA team
Cheng, Y.W.; Tsai, H.J.; Wu, J.Y.; Hsu, Y.F.; Chen, C.Y.; Hao, N.J.; Lee, H.
A possible role for dihydrodiol dehydrogenase in the formation of benzo[a]pyrene-DNA adducts in lung cancer cells and tumor tissues
Environ. Mol. Mutagen.
48
14-21
2006
Homo sapiens
Manually annotated by BRENDA team
Chen, Y.J.; Yuan, C.C.; Chow, K.C.; Wang, P.H.; Lai, C.R.; Yen, M.S.; Wang, L.S.
Overexpression of dihydrodiol dehydrogenase is associated with cisplatin-based chemotherapy resistance in ovarian cancer patients
Gynecol. Oncol.
97
110-117
2005
Homo sapiens
Manually annotated by BRENDA team
Chow, K.C.; Lu, M.P.; Wu, M.T.
Expression of dihydrodiol dehydrogenase plays important roles in apoptosis- and drug-resistance of A431 squamous cell carcinoma
J. Dermatol. Sci.
41
205-212
2006
Homo sapiens
Manually annotated by BRENDA team
Carbone, V.; Sumii, R.; Ishikura, S.; Asada, Y.; Hara, A.; El-Kabbani, O.
Structure of monkey dimeric dihydrodiol dehydrogenase in complex with isoascorbic acid
Acta Crystallogr. Sect. D
64
532-542
2008
Macaca fuscata, Macaca fascicularis (Q9TQS6)
Manually annotated by BRENDA team
Pan, B.F.; Nelson, J.A.
Dihydrodiol dehydrogenase in drug resistance and sensitivity of human carcinomas
Cancer Chemother. Pharmacol.
59
697-702
2007
Homo sapiens
Manually annotated by BRENDA team
Carbone, V.; Hara, A.; El-Kabbani, O.
Structural and functional features of dimeric dihydrodiol dehydrogenase
Cell. Mol. Life Sci.
65
1464-1474
2008
Macaca fascicularis, Sus scrofa, Bos taurus (Q148L6), Pongo abelii (Q5R5J5), Mus musculus (Q9DBB8)
Manually annotated by BRENDA team
Wang, H.W.; Lin, C.P.; Chiu, J.H.; Chow, K.C.; Kuo, K.T.; Lin, C.S.; Wang, L.S.
Reversal of inflammation-associated dihydrodiol dehydrogenases (AKR1C1 and AKR1C2) overexpression and drug resistance in nonsmall cell lung cancer cells by wogonin and chrysin
Int. J. Cancer
120
2019-2027
2007
Homo sapiens (P52895), Homo sapiens (Q04828)
Manually annotated by BRENDA team
Carbone, V.; Endo, S.; Sumii, R.; Chung, R.P.; Matsunaga, T.; Hara, A.; El-Kabbani, O.
Structures of dimeric dihydrodiol dehydrogenase apoenzyme and inhibitor complex: probing the subunit interface with site-directed mutagenesis
Proteins Struct. Funct. Bioinform.
70
176-187
2007
Macaca fascicularis
-
Manually annotated by BRENDA team
Chang, H.C.; Chen, Y.L.; Chan, C.P.; Yeh, K.T.; Kuo, S.J.; Ko, C.J.; Fang, H.Y.
Overexpression of dihydrodiol dehydrogenase as a prognostic marker in resected gastric cancer patients
Digest. Dis. Sci.
54
342-347
2009
Homo sapiens
Manually annotated by BRENDA team
Carbone, V.; Endo, S.; Sumii, R.; Chung, R.; Matsunaga, T.; Hara, A.; El-Kabbani, O.
Structures of dimeric dihydrodiol dehydrogenase apoenzyme and inhibitor complex: Probing the subunit interface with site-directed mutagenesis
Proteins Struct. Funct. Genet.
70
176-187
2008
Macaca fascicularis (Q9TQS6)
Manually annotated by BRENDA team
Liu, D.; Pan, L.; Li, Z.; Cai, Y.; Miao, J.
Metabolites analysis, metabolic enzyme activities and bioaccumulation in the clam Ruditapes philippinarum exposed to benzo[a]pyrene
Ecotoxicol. Environ. Saf.
107
251-259
2014
Ruditapes philippinarum
Manually annotated by BRENDA team