1.3.1.20: trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
This is an abbreviated version!
For detailed information about trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, go to the full flat file.
Word Map on EC 1.3.1.20
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1.3.1.20
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dihydrodiol
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trans-dihydrodiols
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medicine
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polycyclic
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catechols
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nadp+-dependent
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benzenedihydrodiol
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indomethacin
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penning
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alpha-hydroxysteroids
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o-quinones
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talalay
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anti-diol
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1.1.1.184
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+/-trans-7,8-dihydroxy-7,8-dihydrobenzoapyrene
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non-k-region
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benzaanthracene
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alicyclic
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trans-1,2-dihydrodiols
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dicoumarol
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chrysene
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benzoapyrene-7,8-dione
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harvey
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pah-induced
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androsterone
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diagnostics
- 1.3.1.20
- dihydrodiol
-
trans-dihydrodiols
- medicine
-
polycyclic
- catechols
-
nadp+-dependent
- benzenedihydrodiol
- indomethacin
-
penning
-
alpha-hydroxysteroids
- o-quinones
-
talalay
-
anti-diol
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1.1.1.184
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+/-trans-7,8-dihydroxy-7,8-dihydrobenzoapyrene
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non-k-region
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benzaanthracene
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alicyclic
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trans-1,2-dihydrodiols
- dicoumarol
- chrysene
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benzoapyrene-7,8-dione
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harvey
-
pah-induced
- androsterone
- diagnostics
Reaction
Synonyms
AKR1C1, AKR1C2, DD, DDH, DDH1, DDH2, dehydrogenase, trans-1,2-dihydrobenzene-1,2-diol, DHDH, dihydrodiol dehydrogenase, More
ECTree
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Inhibitors
Inhibitors on EC 1.3.1.20 - trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
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chenodeoxycholic acid
DD2 very sensitive, DD1 less sensitive, recombinant DD1
chrysin
inhibits enzyme expression at concentrations higher than 0.01 mM; inhibits enzyme expression at concentrations higher than 0.01 mM
doxorubicin hydrochloride
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50% inhibition at 0.000706 mM, parental 2008 cell, at 0.000377, 2008/C13* cell, at 0.000375 mM, 2008 cell expressing isoform 2
melphalan
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50% inhibition at 0.009 mM, parental 2008 cell, at 0.0088, 2008/C13* cell, at 0.0057 mM, 2008 cell expressing isoform 2
paclitaxel
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50% inhibition at 0.0000393 mM, parental 2008 cell, at 0.0000101, 2008/C13* cell, at 0.0000283 mM, 2008 cell expressing isoform 2
Ursodeoxycholic acid
very sensitiv: DD2, less sensitiv: DD1, recombinant DD1
vincristine
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50% inhibition at 0.000021 mM, parental 2008 cell, at 0.000016, 2008/C13* cell, at 0.0000136 mM, 2008 cell expressing isoform 2
wogonin
inhibits enzyme expression at concentrations higher than 0.0025 mM; inhibits enzyme expression at concentrations higher than 0.0025 mM
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i.e. DTNB, inhibits wild-type enzyme and mutant C145S
5,5'-dithiobis(2-nitrobenzoic acid)
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inhibits DD1 and DD3, inhibition can be overcome by androsterone for DD1 and by benzenedihydrodiol for DD3, not vice versa
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50% inhibition at 0.0358 mM, parental 2008 cell, at 0.578, 2008/C13* cell, at 0.0974 mM, 2008 cell expressing isoform 1, at 0.0871 mM, 2008 cell expressing isoform 2
carboplatin
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50% inhibition at 0.036 mM, 2008 cells, at 0.578 mM, 2008/C13* cells, at 0.097 mM, cells constitutively overexpressing enzyme
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50% inhibition at 0.0021 mM, parental 2008 cell, at 0.0186, 2008/C13* cell, at 0.0161 mM, 2008 cell expressing isoform 1, at 0.0062 mM, 2008 cell expressing isoform 2
cisplatin
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50% inhibition at 0.002 mM, 2008 cells, at 0.019 mM, 2008/C13* cells, at 0.016 mM, cells constitutively overexpressing enzyme
additional information
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DD4 is inhibited by steroidal anti-inflammatory drugs
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additional information
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DD2, product inhibition and inhibition mechanism of bile acids and anti-inflammatory drugs
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additional information
enzyme expression is not inhibited by baicalin and baicalein; enzyme expression is not inhibited by baicalin and baicalein
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additional information
enzyme expression is not inhibited by baicalin and baicalein; enzyme expression is not inhibited by baicalin and baicalein
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additional information
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inhibition by nonsteroidal antiinflammatory drugs
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