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1.3.1.20: trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

This is an abbreviated version!
For detailed information about trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, go to the full flat file.

Word Map on EC 1.3.1.20

Reaction

trans-1,2-Dihydrobenzene-1,2-diol
+
NADP+
=
catechol
+
NADPH
+
H+

Synonyms

AKR1C1, AKR1C2, DD, DDH, DDH1, DDH2, dehydrogenase, trans-1,2-dihydrobenzene-1,2-diol, DHDH, dihydrodiol dehydrogenase, More

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

Inhibitors

Inhibitors on EC 1.3.1.20 - trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
1,7-phenanthroline
DD1, recombinant DD1, but DD2 less sensitive
1-Indanone
-
recombinant DD4
17beta-estradiol
2,6-dihydroxyanthraquinone
3',3'',5',5''-tetrabromophenolphthalein
-
recombinant DD4
4-hydroxyacetophenone
4-hydroxybenzaldehyde
-
-
4-hydroxybenzophenone
-
-
4-hydroxyphenylglyoxal
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
5alpha-androstan-3,17-dione
-
DD3
5alpha-Androstan-3-beta-ol-17-one
-
-
5alpha-Pregnan-3beta-21-one
-
-
5beta-androstan-3,17-dione
-
DD3
5beta-Androstan-3alpha-ol-17-one
-
DD3
5beta-androstan-3beta-ol-17-one
-
-
5beta-Pregnan-3beta-ol-20-one
-
-
androsterone
-
DD3
ascorbate
-
-
Barbital
Benzo[a]pyrene-7,8-dione
-
-
Betamethasone
Bromophenol blue
-
recombinant DD4
carboplatin
chenodeoxycholic acid
DD2 very sensitive, DD1 less sensitive, recombinant DD1
chrysin
inhibits enzyme expression at concentrations higher than 0.01 mM; inhibits enzyme expression at concentrations higher than 0.01 mM
Cibacron blue
-
-
cisplatin
cyclopentane-1,1-diacetic acid NaCl
-
inhibits only isoform F2
Dehydrolithocholic acid
-
DD2
dexamethasone
Dienstrol
-
-
diphosphate
-
high concentration: F2 slight inhibition, F1 stimulation
doxorubicin hydrochloride
-
50% inhibition at 0.000706 mM, parental 2008 cell, at 0.000377, 2008/C13* cell, at 0.000375 mM, 2008 cell expressing isoform 2
Flufenamic acid
glutathione
-
wild-type and mutant C145S
Hexestrol
Ibuprofen
very sensitive: DD2, less sensitive: DD1, recombinant DD1
indomethacin
isoascorbic acid
KCl
-
increase in Km-value for D-xylose and NADP+
L-ascorbic acid
lithocholic acid
medroxyprogesterone
-
DD4 wild-type and mutants
Medroxyprogesterone acetate
-
recombinant: DD1, DD4, CDD1-4, CDD4-1
melphalan
-
50% inhibition at 0.009 mM, parental 2008 cell, at 0.0088, 2008/C13* cell, at 0.0057 mM, 2008 cell expressing isoform 2
MgCl2
N-ethylmaleimide
-
wild-type and mutant C145S
naphthalene-1,2-dione
-
-
naproxen
-
DD2
p-chloromercuribenzene sulfonate
-
stronger effect on isoform F2
p-chloromercuribenzoate
-
stronger effect on isoform F1
p-chloromercuriphenyl sulfonate
paclitaxel
-
50% inhibition at 0.0000393 mM, parental 2008 cell, at 0.0000101, 2008/C13* cell, at 0.0000283 mM, 2008 cell expressing isoform 2
Phenol red
-
recombinant DD4
Phenolphthalein
phenolphthalein phosphate
-
recombinant DD4
phosphate buffer
-
inhibitionn of mutant enzymes H79Q and Y180F
-
quercitrin
SO42-
-
inhibits only isoform F1
sorbinil
Stilbestrol
testosterone
-
-
Thiol-blocking reagents
-
F1
-
Thymolphthalein
-
recombinant DD4
Ursodeoxycholic acid
very sensitiv: DD2, less sensitiv: DD1, recombinant DD1
ursodeoxylithocholic acid
-
DD2
vincristine
-
50% inhibition at 0.000021 mM, parental 2008 cell, at 0.000016, 2008/C13* cell, at 0.0000136 mM, 2008 cell expressing isoform 2
wogonin
inhibits enzyme expression at concentrations higher than 0.0025 mM; inhibits enzyme expression at concentrations higher than 0.0025 mM
additional information
-