1.3.1.2: dihydropyrimidine dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about dihydropyrimidine dehydrogenase (NADP+), go to the full flat file.

Reaction

Synonyms

4,5-dihydrothymine: oxidoreductase, dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate), DHPDH, DHPDHase, DHU dehydrogenase, dihydropyrimidine dehydrogenase, dihydrothymine dehydrogenase, Dihydrouracil dehydrogenase, dihydrouracil dehydrogenase (NADP), dihydrouracil dehydrogenase (NADP+), DPD, DPYD, hydropyrimidine dehydrogenase

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.1 With NAD⁺ or NADP⁺ as acceptor

                1.3.1.2 dihydropyrimidine dehydrogenase (NADP+)

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Results	in table
5	Activating Compound
2252	AA Sequence
13	Application
1	CAS Registry Number
8	Cloned(Commentary)
70	Cofactor
4	Crystallization (Commentary)
42	Disease/ Diagnostics
5	General Information
9	General Stability
6	IC50 Value
79	Inhibitors
19	kcat/KM [mM/s]
21	Ki Value [mM]
74	KM Value [mM]
19	Localization
11	Metals/Ions
21	Molecular Weight [Da]
50	Natural Substrates/ Products (Substrates)
57	Organism
11	Pathway
40	PDB ID
8	pH Optimum
2	pH Range
1	pH Stability
20	Protein Variants
23	Purification (Commentary)
7	Reaction
3	Reaction Type
57	Reference
51	Source Tissue
27	Specific Activity [micromol/min/mg]
4	Storage Stability
146	Substrates and Products (Substrate)
11	Subunits
29	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
1	Temperature Stability [°C]
17	Turnover Number [1/s]

Disease

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Disease on EC 1.3.1.2 - dihydropyrimidine dehydrogenase (NADP+)

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Breast Neoplasms

Antitumor effect of combination of S-1 and docetaxel on the human breast cancer xenograft transplanted into SCID mice.

16685389

Carcinoma, Hepatocellular

Dihydrouracil dehydrogenase activity in normal, differentiating and regnerating liver and in hepatomas.

4397791

Chickenpox

Inhibition of fluorouracil catabolism in cancer patients by the antiviral agent (E)-5-(2-bromovinyl)-2'-deoxyuridine.

8045919

dihydropyrimidine dehydrogenase (nadp+) deficiency

A screening method for dihydropyrimidine dehydrogenase deficiency with colorimetric detection of urinary uracil.

2624179

dihydropyrimidine dehydrogenase (nadp+) deficiency

Acute confusion induced by a high-dose infusion of 5-fluorouracil and folinic acid.

7858459

Head and Neck Neoplasms

A phase II study of S-1 in patients with metastatic breast cancer--a Japanese trial by the S-1 Cooperative Study Group, Breast Cancer Working Group.

15550867

Herpes Simplex

Inhibition of fluorouracil catabolism in cancer patients by the antiviral agent (E)-5-(2-bromovinyl)-2'-deoxyuridine.

8045919

Herpes Zoster

Inhibition of fluorouracil catabolism in cancer patients by the antiviral agent (E)-5-(2-bromovinyl)-2'-deoxyuridine.

8045919

Neoplasms

Antitumor effect of combination of S-1 and docetaxel on the human breast cancer xenograft transplanted into SCID mice.

16685389

Neoplasms

Comparison of dihydropyrimidine dehydrogenase from human, rat, pig and cow liver. Biochemical and immunological properties.

8373446

Neoplasms

Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators.

8862723

Neoplasms

Effect of administration of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on the anti-tumor efficacy of 5-fluoro-2'-deoxyuridine against murine colon tumor C26-10.

10927027

Neoplasms

Enzymes of uracil catabolism in normal and neoplastic human tissues.

3931905

Thiamine Deficiency

Acute confusion induced by a high-dose infusion of 5-fluorouracil and folinic acid.

7858459

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