1.3.1.15: dihydroorotate dehydrogenase (NADP+)

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For detailed information about dihydroorotate dehydrogenase (NADP+), go to the full flat file.

Reaction

Synonyms

reductase, orotate (reduced nicotinamide adenine dinucleotide phosphate), triphosphopyridine-linked dihydroorotic dehydrogenase

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.1 With NAD⁺ or NADP⁺ as acceptor

                1.3.1.15 dihydroorotate dehydrogenase (NADP+)

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1	AA Sequence
1	CAS Registry Number
4	Cofactor
5	Inhibitors
3	KM Value [mM]
1	Localization
1	Metals/Ions
2	Natural Substrates/ Products (Substrates)
2	Organism
2	pH Optimum
1	pH Range
1	Purification (Commentary)
1	Reaction
3	Reaction Type
2	Reference
1	Specific Activity [micromol/min/mg]
2	Storage Stability
4	Substrates and Products (Substrate)
2	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]
1	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.3.1.15 - dihydroorotate dehydrogenase (NADP+)

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SYSTEMATIC NAME

IUBMB Comments

(S)-dihydroorotate:NADP+ oxidoreductase

Binds FMN and FAD [2]. Other class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1) or NAD+ (EC 1.3.1.14) as electron acceptor. The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor .