1.3.1.12: prephenate dehydrogenase

This is an abbreviated version!
For detailed information about prephenate dehydrogenase, go to the full flat file.

Word Map on EC 1.3.1.12

1.3.1.12

l-tyrosine

h-protein

arogenate

hyperglycinemia

nonketotic

4-hydroxyphenylpyruvate

aminomethyltransferase

dahp

3-deoxy-d-arabino-heptulosonate

cyclohexadienyl

7-phosphate

dimethylglycine

tetrahydrofolate-dependent

glycine-cleavage

aminomethyl

folate-binding

Reaction

Synonyms

AceF, AroQ, bifunctional T-protein, chorismate mutase-prephenate dehydratase, chorismate mutase-prephenate dehydrogenase bifunctional enzyme, chorismate mutase-T:prephenate dehydrogenase bifunctional enzyme, Chorismate mutase/prephenate dehydratase, CM-PD, CM-TyrAp, CM/PDT/PDHG, CMPD, dehydrogenase, prephenate, hydroxyphenylpyruvate synthase, PD, PDH, pdhE-1, PDHG, T-protein, TYR1, tyrA, TyrA dehydrogenase, TyrAp

ECTree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.1.12 prephenate dehydrogenase

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Results	in table
8	Activating Compound
11849	AA Sequence
2	Application
3	CAS Registry Number
21	Cloned(Commentary)
37	Cofactor
5	Crystallization (Commentary)
4	General Information
21	General Stability
1	IC50 Value
105	Inhibitors
7	kcat/KM [mM/s]
26	Ki Value [mM]
82	KM Value [mM]
6	Metals/Ions
33	Molecular Weight [Da]
60	Natural Substrates/ Products (Substrates)
277	Organism
8	Pathway
21	PDB ID
11	pH Optimum
3	pH Range
1	pI Value
1	Posttranslational Modification
18	Protein Variants
36	Purification (Commentary)
3	Reaction
4	Reaction Type
80	Reference
29	Specific Activity [micromol/min/mg]
13	Storage Stability
140	Substrates and Products (Substrate)
18	Subunits
79	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
4	Temperature Range [°C]
6	Temperature Stability [°C]
51	Turnover Number [1/s]

Purification

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Purification on EC 1.3.1.12 - prephenate dehydrogenase

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5 entries

by Ni-NTA column

Aquifex aeolicus

674545

by nickel-affinity chromatography

Aquifex aeolicus

677010

chorismate mutase-prephenate dehydrogenase bifunctional enzyme

3 entries

copurification with arogenate dehydrogenase

2 entries

copurification with pretyrosine dehydrogenase

Pseudomonas aeruginosa

390547

His-rMtPDH, to near homogeneity by Ni-NTA affinity chromatography, ca. 94% pure

Mycobacterium tuberculosis

676965

His6-tagged proteins, to homogeneity by gel filtration

Escherichia coli

671431

Ni-NTA column chromatography

Haemophilus influenzae

740113

not associated with other enzymatic activities

Cupriavidus necator

3542

one-step procedure by affinity chromatography

partial

recombinant enzyme

recombinant His-tagged enzyme from Escherichia coli by nickel affinity chromatography, cleavage of the tag by TEV protease

Haemophilus influenzae

P43902

710738

recombinant His-tagged wild-type enzyme and enzyme fragments

recombinant protein

together with arogenate dehydrogenase

Microtetraspora glauca

390511

wild-type and mutant enzyme

Escherichia coli

390552