1.3.1.105: 2-methylene-furan-3-one reductase

This is an abbreviated version!
For detailed information about 2-methylene-furan-3-one reductase, go to the full flat file.

Reaction

Synonyms

FaEO, SIEO

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.1 With NAD⁺ or NADP⁺ as acceptor

                1.3.1.105 2-methylene-furan-3-one reductase

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Results	in table
27	AA Sequence
4	Cloned(Commentary)
6	Cofactor
1	Crystallization (Commentary)
2	Expression
1	General Information
1	Inhibitors
9	kcat/KM [mM/s]
9	KM Value [mM]
1	Localization
2	Metals/Ions
3	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
6	Organism
2	Pathway
1	pH Optimum
1	pH Range
3	Purification (Commentary)
1	Reaction
6	Reference
4	Source Tissue
16	Substrates and Products (Substrate)
3	Subunits
5	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
6	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 1.3.1.105 - 2-methylene-furan-3-one reductase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(2E)-2-butylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADH + H+

2-butyl-4-hydroxy-5-methyl-3(2H)-furanone + NAD+

2 entries

(2E)-4-hydroxy-5-methyl-2-propylidene-3(2H)-furanone + NADH + H+

4-hydroxy-5-methyl-2-propyl-3(2H)-furanone + NAD+

2 entries

(2E)-ethylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADH + H+

2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NAD+

2 entries

(2E)-ethylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADPH + H+

2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + 5-ethyl-4-hydroxy-2-methyl-3(2H)-furanone + NADP+

Fragaria vesca

O23939

-

722809

-

-

?

4-hydroxy-5-methyl-2-methylene-3(2H)-furanone + NADH + H+

(2R)-4-hydroxy-2,5-dimethyl-3(2H)-furanone + NAD+

Fragaria vesca

O23939

kcat/Km for NADH is 7.5fold lower than for NADPH, Re-specific, i.e. the 4R-hydride of NAD(P)H is transferred

722809

-

-

?

4-hydroxy-5-methyl-2-methylene-3(2H)-furanone + NADH + H+

4-hydroxy-2,5-dimethyl-3(2H)-furanone + NAD+

2 entries

4-hydroxy-5-methyl-2-methylene-3(2H)-furanone + NADPH + H+

(2R)-4-hydroxy-2,5-dimethyl-3(2H)-furanone + NADP+

Fragaria vesca

O23939

kcat/Km for NADH is 7.5fold lower than for NADPH, Re-specific, i.e. the 4R-hydride of NAD(P)H is transferred

722809

-

-

?

4-hydroxy-5-methyl-2-methylene-3(2H)-furanone + NADPH + H+

4-hydroxy-2,5-dimethyl-3(2H)-furanone + NADP+

Fragaria x ananassa

Q941I0

-

723403

-

-

?

9,10-phenanthrenequinone + NADH + H+

? + NAD+

Fragaria x ananassa

Q941I0

-

722429

-

-

?

additional information

?

-

2 entries

(2E)-2-butylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADH + H+

2-butyl-4-hydroxy-5-methyl-3(2H)-furanone + NAD+

Fragaria x ananassa

Q941I0

-

722429

-

-

?

(2E)-2-butylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADH + H+

2-butyl-4-hydroxy-5-methyl-3(2H)-furanone + NAD+

Solanum lycopersicum

-

-

722429

-

-

?

(2E)-4-hydroxy-5-methyl-2-propylidene-3(2H)-furanone + NADH + H+

4-hydroxy-5-methyl-2-propyl-3(2H)-furanone + NAD+

Fragaria x ananassa

Q941I0

-

722429

-

-

?

(2E)-4-hydroxy-5-methyl-2-propylidene-3(2H)-furanone + NADH + H+

4-hydroxy-5-methyl-2-propyl-3(2H)-furanone + NAD+

Solanum lycopersicum

-

-

722429

-

-

?

(2E)-ethylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADH + H+

2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NAD+

Fragaria x ananassa

Q941I0

-

722429

-

-

?

(2E)-ethylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADH + H+

2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NAD+

Solanum lycopersicum

-

-

722429

-

-

?

4-hydroxy-5-methyl-2-methylene-3(2H)-furanone + NADH + H+

4-hydroxy-2,5-dimethyl-3(2H)-furanone + NAD+

Fragaria x ananassa

Q941I0

-

722429, 723403

-

-

?

4-hydroxy-5-methyl-2-methylene-3(2H)-furanone + NADH + H+

4-hydroxy-2,5-dimethyl-3(2H)-furanone + NAD+

Solanum lycopersicum

-

-

722429

-

-

?

additional information

?

-

Fragaria x ananassa

Q941I0

no reaction with (2E)-2-hexenal, (3E)-3-hexen-2-one, (3E)-5-methyl-3-hexen-2-one, cyclohexa-1,2-dione, buta-2,3-dione, coumarin, astaxanthin, cinnamyl aldehyde, 4-coumaric acid, ferulic acid, dimethoxycinnamic acid, or benzil

722429

-

-

?

additional information

?

-

Solanum lycopersicum

-

no reaction with (2E)-2-hexenal, (3E)-3-hexen-2-one, (3E)-5-methyl-3-hexen-2-one, cyclohexa-1,2-dione, buta-2,3-dione, coumarin, astaxanthin, cinnamyl aldehyde, 4-coumaric acid, ferulic acid, dimethoxycinnamic acid, or benzil

722429

-

-

?