1.3.1.104: enoyl-[acyl-carrier-protein] reductase (NADPH)

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For detailed information about enoyl-[acyl-carrier-protein] reductase (NADPH), go to the full flat file.

Reaction

trans-2,3-dehydroacyl-[acyl-carrier protein]

Synonyms

enoyl-ACP reductase, enoyl-acyl carrier protein reductase, enoyl-[acyl carrier protein] (reduced nicotinamide adenine dinucleotide phosphate) reductase, ENR, ETR1, FabI, FabL, Fabl2, JamJ, NADPH 2-enoyl Co A reductase, NWMN_0881, YgaA

ECTree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.1.104 enoyl-[acyl-carrier-protein] reductase (NADPH)

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Results	in table
624	AA Sequence
2	Application
7	Cloned(Commentary)
7	Cofactor
2	Crystallization (Commentary)
4	General Information
1	General Stability
1	IC50 Value
7	Inhibitors
2	Ki Value [mM]
4	KM Value [mM]
1	Localization
1	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
21	Organism
12	Pathway
2	PDB ID
1	pH Optimum
31	Protein Variants
1	Reaction
15	Reference
1	Specific Activity [micromol/min/mg]
14	Substrates and Products (Substrate)
6	Subunits
25	Synonyms
1	Systematic Name
5	Temperature Stability [°C]
2	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 1.3.1.104 - enoyl-[acyl-carrier-protein] reductase (NADPH)

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crotonyl-CoA + NADPH + H+

butanoyl-CoA + NADP+

2 entries

crotonyl-CoA + NADPH + H+

butyryl-CoA + NADP+

uncultured bacterium pBF1

763903

crotonyl-N-acetylcysteamine + NADPH + H+

butyryl-N-acetylcysteamine + NADP+

Staphylococcus aureus

Q9RMI3

390504

crotonyl-[acyl-carrier-protein] + NADPH + H+

butyryl-[acyl-carrier-protein] + NADP+

5 entries

gama-chloro-beta-methylcrotonyl-[acyl-carrier-protein] + NADPH + H+

gama-chloro-beta-methylbutanoyl-[acyl-carrier-protein] + NADP+

Lyngbya majuscula

Q6E7K0

743859

trans-2-octenoyl-N-acetylcysteamine + NADPH + H+

octanoyl-N-acetylcysteamine + NADP+

3 entries

additional information

uncultured bacterium pBF1

the enzyme shows no 7-alpha hydroxysteroid dehydrogenase activity when tested with cholic acid substrate and NADH and NADPH cofactors. The purified protein does not utilize NADH as a cofactor when tested with crotonyl-[CoA] as substrate

763903