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1.3.1.104: enoyl-[acyl-carrier-protein] reductase (NADPH)

This is an abbreviated version!
For detailed information about enoyl-[acyl-carrier-protein] reductase (NADPH), go to the full flat file.

Reaction

acyl-[acyl-carrier protein]
+
NADP+
=
trans-2,3-dehydroacyl-[acyl-carrier protein]
+
NADPH
+
H+

Synonyms

enoyl-ACP reductase, enoyl-acyl carrier protein reductase, enoyl-[acyl carrier protein] (reduced nicotinamide adenine dinucleotide phosphate) reductase, ENR, ETR1, FabI, FabL, Fabl2, JamJ, NADPH 2-enoyl Co A reductase, NWMN_0881, YgaA

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.104 enoyl-[acyl-carrier-protein] reductase (NADPH)

Inhibitors

Inhibitors on EC 1.3.1.104 - enoyl-[acyl-carrier-protein] reductase (NADPH)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
AFN-1252
antibiotic AFN-1252, i.e. (2E)-N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)prop-2-enamide, only binds to the NADPH form of FabI
Hexachlorophene
-
triclosan
additional information
-
the enzyme is resistant to triclosan
-