Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.3.1.10: enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)

This is an abbreviated version!
For detailed information about enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific), go to the full flat file.

Word Map on EC 1.3.1.10

Reaction

acyl-[acyl-carrier protein]
+
NADP+
=
trans-2,3-dehydroacyl-[acyl-carrier protein]
+
NADPH
+
H+

Synonyms

1-cyclohexenylcarbonyl coenzyme A reductase, 2-enoyl thioester reductase, 2-trans-enoyl-ACP reductase, acyl-ACP dehydrogenase, beta-ketoacyl reductase, enoyl acyl-carrier-protein reductase, enoyl reductase, enoyl thioester reductase, enoyl-ACP reductase, enoyl-ACP reductase II, enoyl-ACP reductase III, enoyl-ACP-reductase II, enoyl-acyl carrier protein reductase, enoyl-[acyl carrier protein] reductase, enoyl-[acyl-carrier-protein] reductase, ENR, Etr1p, fabG4, FabI, FabK, FabL, Fabl2, More, Mrf1p, NADPH 2-enoyl Co A reductase, reductase, enoyl-[acyl carrier protein] (reduced nicotinamide adenine dinucleotide phosphate), trans-enoyl-[acyl-carrier-protein] reductase, YgaA

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)

Reference

Reference on EC 1.3.1.10 - enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Shimakata, T.; Stumpf, P.K.
The procaryotic nature of the fatty acid synthetase of developing Carthamus tinctorius L. (Safflower) seeds
Arch. Biochem. Biophys.
217
144-154
1982
Carthamus tinctorius
Manually annotated by BRENDA team
Saito, K.; Kawaguchi, A.; Seyama, Y.; Yamakawa, T.; Okuda, S.
Steric course of reaction catalyzed by the enoyl acyl-carrier-protein reductase of Escherichia coli
Eur. J. Biochem.
116
581-586
1981
Escherichia coli
Manually annotated by BRENDA team
Sedgwick, B.; Morris, C.
Stereochemical course of hydrogen transfer catalysed be the enoyl reductase enzyme of the yeast fatty acid synthethase
J. Chem. Soc. Chem. Commun.
1980
96-97
1980
Saccharomyces cerevisiae
-
Manually annotated by BRENDA team
Seyama, Y.; Kasama, T.; Yamakawa, T.; Kawaguchi, A.; Saito, K.; Okuda, S.
Origin of hydrogen atoms in the fatty acids synthesized with yeast fatty acid synthetase
J. Biochem.
82
1325-1329
1977
Saccharomyces cerevisiae, Escherichia coli
Manually annotated by BRENDA team
Weeks, G.; Wakil, S.J.
Enoyl acyl carrier protein reductase from Escherichia coli
Methods Enzymol.
14
66-73
1969
Escherichia coli
-
Manually annotated by BRENDA team
Weeks, G.; Wakil, S.J.
Studies on the mechanism of fatty acid synthesis. 18. Preparation and general properties of the enoyl acyl carrier protein reductases from Escherichia coli
J. Biol. Chem.
243
1180-1189
1968
Escherichia coli
Manually annotated by BRENDA team
Saito, K.; Kawaguchi, A.; Okuda, S.; Seyama, Y.; Yamakawa, T.
Incorporation of hydrogen atoms from deuterated water and stereospecifically deuterium-labeled nicotin amide nucleotides into fatty acids with the Escherichia coli fatty acid synthetase system
Biochim. Biophys. Acta
618
202-213
1980
Escherichia coli
Manually annotated by BRENDA team
Bergler, H.; Fuchsbichler, S.; Hoegenauer, G.; Turnowsky, F.
The enoyl-[acyl-carrier-protein] reductase (FabI) of Escherichia coli, which catalyzes a key regulatory step in fatty acid biosynthesis, accepts NADH and NADPH as cofactors and is inhibited by palmitoyl-CoA
Eur. J. Biochem.
242
689-694
1996
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Heath, R.J.; Li, J.; Roland, G.E.; Rock, C.O.
Inhibition of the Staphylococcus aureus NADPH-dependent enoyl-acyl carrier protein reductase by triclosan and hexachlorophene
J. Biol. Chem.
275
4654-4659
2000
Escherichia coli, Staphylococcus aureus (Q9RMI3), Staphylococcus aureus
Manually annotated by BRENDA team
Heath, R.J.; Su, N.; Murphy, C.K.; Rock, C.O.
The enoyl-[acyl-carrier-protein] reductases FabI and FabL from Bacillus subtilis
J. Biol. Chem.
275
40128-40133
2000
Bacillus subtilis, Bacillus subtilis (P71079)
Manually annotated by BRENDA team
Turnowsky, F.; Fuchs, K.; Jeschek, C.; Hogenauer, G.
EnvM genes of Salmonella typhimurium and Escherichia coli
J. Bacteriol.
171
6555-6565
1989
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Bergler, H.; Hogenauer, G.; Turnowsky, F.
Sequences of the envM gene and of two mutated alleles in Escherichia coli
J. Gen. Microbiol.
138
2093-2100
1992
Escherichia coli
Manually annotated by BRENDA team
Heath, R.J.; Rock, C.O.
A triclosan-resistant bacterial enzyme
Nature
406
145-146
2000
Streptococcus pneumoniae
Manually annotated by BRENDA team
Wang, P.; Denoya, C.D.; Morgenstern, M.R.; Skinner, D.D.; Kimberlee, K.W.; Digate, R.; Patton, S.; Banavali, N.; Schuler, G.; Speedie, M.K.; Reynolds, K.A.
Cloning and characterization of the gene encoding 1-cyclohexenylcarbonyl coenzyme A reductase from Streptomyces collinus
J. Bacteriol.
178
6873-6881
1996
Streptomyces collinus
Manually annotated by BRENDA team
Airenne, T.T.; Torkko, J.M.; Van den plas, S.; Sormunen, R.T.; Kastaniotis, A.J.; Wierenga, R.K.; Kalervo Hiltunen, J.
Structure-function analysis of enoyl thioester reductase involved in mitochondrial maintenance
J. Mol. Biol.
327
47-59
2003
Candida tropicalis, Saccharomyces cerevisiae (P38071), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Kim, K.H.; Park, J.K.; Ha, B.H.; Moon, J.H.; Kim, E.E.
Crystallization and preliminary X-ray crystallographic analysis of enoyl-ACP reductase III (FabL) from Bacillus subtilis
Acta Crystallogr. Sect. F
63
246-248
2007
Bacillus subtilis, Bacillus subtilis 168
Manually annotated by BRENDA team
Xu, H.; Sullivan, T.J.; Sekiguchi, J.; Kirikae, T.; Ojima, I.; Stratton, C.F.; Mao, W.; Rock, F.L.; Alley, M.R.; Johnson, F.; Walker, S.G.; Tonge, P.J.
Mechanism and inhibition of saFabI, the enoyl reductase from Staphylococcus aureus
Biochemistry
47
4228-4236
2008
Staphylococcus aureus
Manually annotated by BRENDA team
Gurvitz, A.
A novel circuit overrides Adr1p control during expression of Saccharomyces cerevisiae 2-trans-enoyl-ACP reductase Etr1p of mitochondrial type 2 fatty acid synthase
FEMS Microbiol. Lett.
297
255-260
2009
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Kim, S.J.; Ha, B.H.; Kim, K.H.; Hong, S.K.; Shin, K.J.; Suh, S.W.; Kim, E.E.
Dimeric and tetrameric forms of enoyl-acyl carrier protein reductase from Bacillus cereus
Biochem. Biophys. Res. Commun.
400
517-522
2010
Bacillus cereus, Bacillus cereus (Q81GI3), Bacillus cereus 6A5, Bacillus cereus DSM 31 (Q81GI3)
Manually annotated by BRENDA team
Kwon, Y.J.; Fang, Y.; Xu, G.H.; Kim, W.G.
Aquastatin A, a new inhibitor of enoyl-acyl carrier protein reductase from Sporothrix sp. FN611
Biol. Pharm. Bull.
32
2061-2064
2009
Staphylococcus aureus
Manually annotated by BRENDA team
Hevener, K.E.; Mehboob, S.; Boci, T.; Truong, K.; Santarsiero, B.D.; Johnson, M.E.
Expression, purification and characterization of enoyl-ACP reductase II, FabK, from Porphyromonas gingivalis
Protein Expr. Purif.
85
100-108
2012
Porphyromonas gingivalis (Q7MAW0), Porphyromonas gingivalis, Porphyromonas gingivalis W83 (Q7MAW0)
Manually annotated by BRENDA team
Dutta, D.; Bhattacharyya, S.; Roychowdhury, A.; Biswas, R.; Das, A.
Crystal structure of hexanoyl-CoA bound to beta-ketoacyl reductase FabG4 of Mycobacterium tuberculosis
Biochem. J.
450
127-139
2013
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Yao, J.; Maxwell, J.B.; Rock, C.O.
Resistance to AFN-1252 arises from missense mutations in Staphylococcus aureus enoyl-acyl carrier protein reductase (FabI)
J. Biol. Chem.
288
36261-36271
2013
Staphylococcus aureus, Staphylococcus aureus RN4220
Manually annotated by BRENDA team
Hevener, K.; Santarsiero, B.; Lee, H.; Jones, J.; Boci, T.; Johnson, M.; Mehboob, S.
Structural characterization of Porphyromonas gingivalis enoyl-ACP reductase II (FabK)
Acta Crystallogr. Sect. F
74
105-112
2018
Porphyromonas gingivalis (Q7MAW0), Porphyromonas gingivalis, Porphyromonas gingivalis ATCC BAA-308 (Q7MAW0)
Manually annotated by BRENDA team
Khan, R.; Zeb, A.; Roy, N.; Magar, R.; Kim, H.; Lee, K.; Lee, S.
Biochemical and structural basis of triclosan resistance in a novel enoyl-acyl carrier protein reductase
Antimicrob. Agents Chemother.
62
e00648
2018
uncultured bacterium pBF1 (A0A1C9U547)
Manually annotated by BRENDA team