1.21.99.4: thyroxine 5'-deiodinase

This is an abbreviated version!
For detailed information about thyroxine 5'-deiodinase, go to the full flat file.

Reaction

Synonyms

5DI , 5DII , 5DIII , D1 5'-deiodinase, D2 5'-deiodinase, deiodinase, diiodothyronine 5'-deiodinase, Dio, DIO1, DIO2, DIOI , DIOII , DIOIII , EC 1.97.1.10, EC 3.8.1.4, ID-1, ID-2, ID-3, iodothyronine 5'-deiodinase, Iodothyronine 5'-monodeiodinase, iodothyronine 5-deiodinase, iodothyronine deiodinase 2, iodothyronine deiodinase D2, iodothyronine inner ring monodeiodinase, iodothyronine outer ring monodeiodinase, L-thyroxine iodohydrolase (reducing), thyroxine 5-deiodinase, Thyroxine deiodinase, type 1 5'-deiodinase, type 1 deiodinase, Type 1 DI , type 1 iodothyronine deiodinase, type 2 5'-deiodinase, type 2 deiodinase, Type 2 DI , type 2 iodothyronine deiodinase, type 3 deiodinase, Type 3 DI , type I iodothyronine 5'-deiodinase, type I iodothyronine deiodinase, type I-like deiodinase, type II iodothyronine deiodinase, type II-like deiodinase, Type-I 5'deiodinase , Type-II 5'deiodinase , Type-III 5'deiodinase , types 1 iodothyronine selenodeiodinase, types 2 iodothyronine selenodeiodinase, XL-15

ECTree

     1 Oxidoreductases

         1.21 Catalysing the reaction X-H + Y-H = X-Y

             1.21.99 With unknown physiological acceptors

                1.21.99.4 thyroxine 5'-deiodinase

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Results	in table
59	Activating Compound
30	AA Sequence
8	Application
1	CAS Registry Number
19	Cloned(Commentary)
18	Cofactor
908	Disease/ Diagnostics
22	Expression
16	General Information
4	General Stability
26	IC50 Value
91	Inhibitors
79	KM Value [mM]
35	Localization
7	Metals/Ions
12	Molecular Weight [Da]
71	Natural Substrates/ Products (Substrates)
239	Organism
2	Pathway
17	pH Optimum
1	pH Range
4	Posttranslational Modification
15	Protein Variants
4	Purification (Commentary)
16	Reaction
2	Reaction Type
94	Reference
1	Renatured (Commentary)
213	Source Tissue
54	Specific Activity [micromol/min/mg]
1	Storage Stability
127	Substrates and Products (Substrate)
19	Subunits
118	Synonyms
1	Systematic Name
15	Temperature Optimum [°C]
3	Temperature Stability [°C]
3	Turnover Number [1/s]

Natural Substrates Products

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of the Enzyme Summary Page.

Natural Substrates Products on EC 1.21.99.4 - thyroxine 5'-deiodinase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

3,3',5'-triiodo-L-thyronine + AH2

3,3'-diiodo-L-thyronine + iodide + A + H+

4 entries

3,3',5'-triiodo-L-thyronine + AH2

3,3'-diiodothyronine + iodide + A + H+

Rattus norvegicus

-

-

639396

-

-

?

3,3',5'-triiodothyronine + AH2

3,3'-diiodothyronine + iodide + A + H+

10 entries

3,3',5-triiodothyronine + AH2

3,3'-diiodothyronine + iodide + A + H+

Rattus sp.

-

isoenzyme type II and type III

639400, 639408

-

-

?

3,3',5-triiodothyronine + AH2

3,5-diiodothyronine + iodide + A + H+

Rattus sp.

-

-

639400

-

-

?

3,5'-diiodo-L-thyronine + AH2

3-iodothyronine + iodide + A + H+

Rattus norvegicus

-

-

639396

-

-

?

L-thyroxine + AH2

3,3',5'-triiodo-L-thyronine + iodide + A + H+

3 entries

L-thyroxine + AH2

3,3',5'-triiodothyronine + iodide + A + H+

3 entries

L-thyroxine + AH2

3,3',5-triiodo-L-thyronine + iodide + A + H+

4 entries

L-thyroxine + AH2

3,3',5-triiodothyronine + iodide + A + H+

4 entries

L-thyroxine + AH2

3,5,3'-triiodo-L-thyronine + iodide + A + H+

8 entries

L-thyroxine + electron acceptor

3,3',5-triiodothyronine + iodide + reduced electron acceptor

Mus musculus

Q9Z1Y9

the enzyme is regulated at the pretranslational level

659941

-

-

?

L-thyroxine + reduced acceptor

3,3',5-triiodo-L-thyronine + iodide + acceptor + H+

Homo sapiens

-

-

745770, 746231

-

-

?

additional information

?

-

3 entries

3,3',5'-triiodo-L-thyronine + AH2

3,3'-diiodo-L-thyronine + iodide + A + H+

Homo sapiens

-

isozyme type I

644806

-

-

?

3,3',5'-triiodo-L-thyronine + AH2

3,3'-diiodo-L-thyronine + iodide + A + H+

Mus musculus

-

isozyme type I

644806

-

-

?

3,3',5'-triiodo-L-thyronine + AH2

3,3'-diiodo-L-thyronine + iodide + A + H+

Rattus norvegicus

-

isozyme type I

644806

-

-

?

3,3',5'-triiodo-L-thyronine + AH2

3,3'-diiodo-L-thyronine + iodide + A + H+

vertebrata

-

isozyme type I

644806

-

-

?

3,3',5'-triiodothyronine + AH2

3,3'-diiodothyronine + iodide + A + H+

Bos taurus

-

-

639412

-

-

?

3,3',5'-triiodothyronine + AH2

3,3'-diiodothyronine + iodide + A + H+

Cavia porcellus

-

-

639412

-

-

?

3,3',5'-triiodothyronine + AH2

3,3'-diiodothyronine + iodide + A + H+

Gallus gallus

-

-

639410, 639412

-

-

?

3,3',5'-triiodothyronine + AH2

3,3'-diiodothyronine + iodide + A + H+

Homo sapiens

-

-

639405, 639409, 639412

-

-

?

3,3',5'-triiodothyronine + AH2

3,3'-diiodothyronine + iodide + A + H+

Mus musculus

-

-

639405, 639412, 715736

-

-

?

3,3',5'-triiodothyronine + AH2

3,3'-diiodothyronine + iodide + A + H+

Oncorhynchus mykiss

-

isoenzyme type I

639410

-

-

?

3,3',5'-triiodothyronine + AH2

3,3'-diiodothyronine + iodide + A + H+

Ovis aries

-

-

639412

-

-

?

3,3',5'-triiodothyronine + AH2

3,3'-diiodothyronine + iodide + A + H+

Rattus sp.

-

-

639414

-

-

?

3,3',5'-triiodothyronine + AH2

3,3'-diiodothyronine + iodide + A + H+

Rattus sp.

-

isoenzyme type I

639400, 639403, 639404, 639405, 639406, 639407, 639408, 639409, 639410, 639412

-

-

?

3,3',5'-triiodothyronine + AH2

3,3'-diiodothyronine + iodide + A + H+

Sus scrofa

-

-

639412

-

-

?

L-thyroxine + AH2

3,3',5'-triiodo-L-thyronine + iodide + A + H+

Mus musculus

Q61153

isoenzyme Dio1

700153

-

-

?

L-thyroxine + AH2

3,3',5'-triiodo-L-thyronine + iodide + A + H+

Rattus norvegicus

-

isozymes type II and I, production of 3,3',5-triiodo-L-thyronine

644806

hormonally inactive

-

?

L-thyroxine + AH2

3,3',5'-triiodo-L-thyronine + iodide + A + H+

vertebrata

-

isozymes type II and I, production of 3,3',5-triiodo-L-thyronine

644806

hormonally inactive

-

?

L-thyroxine + AH2

3,3',5'-triiodothyronine + iodide + A + H+

Oncorhynchus mykiss

-

idothyronine 5'-deiodinase type I

639410

-

-

?

L-thyroxine + AH2

3,3',5'-triiodothyronine + iodide + A + H+

Rattus sp.

-

-

639414

-

-

?

L-thyroxine + AH2

3,3',5'-triiodothyronine + iodide + A + H+

Rattus sp.

-

idothyronine 5'-deiodinase type I

639400, 639410

-

-

?

L-thyroxine + AH2

3,3',5-triiodo-L-thyronine + iodide + A + H+

Homo sapiens

-

-

644806

from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active

-

?

L-thyroxine + AH2

3,3',5-triiodo-L-thyronine + iodide + A + H+

Mus musculus

-

-

644806

from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active

-

?

L-thyroxine + AH2

3,3',5-triiodo-L-thyronine + iodide + A + H+

Rattus norvegicus

-

-

644806

from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active

-

?

L-thyroxine + AH2

3,3',5-triiodo-L-thyronine + iodide + A + H+

vertebrata

-

-

644806

from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active

-

?

L-thyroxine + AH2

3,3',5-triiodothyronine + iodide + A + H+

Oncorhynchus mykiss

-

thyronine 5'-deiodinase type II

639410

-

-

?

L-thyroxine + AH2

3,3',5-triiodothyronine + iodide + A + H+

Rattus norvegicus

P24389

in kidney and liver cells the enzyme can serve as an enzymic barrier to the entry of the prohormone thyroxine and the source of bioactive 3,3',5-triiodothyronine for the cell

659155

-

-

?

L-thyroxine + AH2

3,3',5-triiodothyronine + iodide + A + H+

Rattus sp.

-

-

639411

-

-

?

L-thyroxine + AH2

3,3',5-triiodothyronine + iodide + A + H+

Rattus sp.

-

thyronine 5'-deiodinase type II

639400, 639410, 639415, 639416

-

-

?

L-thyroxine + AH2

3,5,3'-triiodo-L-thyronine + iodide + A + H+

Homo sapiens

-

-

699169, 700172, 700176, 713974

-

-

?

L-thyroxine + AH2

3,5,3'-triiodo-L-thyronine + iodide + A + H+

Homo sapiens

-

isozymes type II and I, production of 3,3',5-triiodo-L-thyronine

644806

hormonally inactive

-

?

L-thyroxine + AH2

3,5,3'-triiodo-L-thyronine + iodide + A + H+

Homo sapiens

P49895

activation and deactivation of thyroid hormone

701298

-

-

r

L-thyroxine + AH2

3,5,3'-triiodo-L-thyronine + iodide + A + H+

Mus musculus

-

-

714664, 715736, 716774

-

-

?

L-thyroxine + AH2

3,5,3'-triiodo-L-thyronine + iodide + A + H+

Mus musculus

-

-

700655

-

-

r

L-thyroxine + AH2

3,5,3'-triiodo-L-thyronine + iodide + A + H+

Mus musculus

Q61153

-

700153

-

-

?

L-thyroxine + AH2

3,5,3'-triiodo-L-thyronine + iodide + A + H+

Mus musculus

-

isozymes type II and I, production of 3,3',5-triiodo-L-thyronine

644806

hormonally inactive

-

?

L-thyroxine + AH2

3,5,3'-triiodo-L-thyronine + iodide + A + H+

Rattus norvegicus

-

-

639396, 701040

-

-

?

additional information

?

-

Homo sapiens

-

thyronines and thyronamines are two groups of endogenous iodine-containing signaling molecules that are substrates of three deiodinase isozymes, which catalyze the sequential reductive removal of iodine from the respective precursor molecule. Development of a analytical method applying liquid chromatography/tandem mass spectrometry, overview

718384

-

-

?

additional information

?

-

Mus musculus

-

thyronines and thyronamines are two groups of endogenous iodine-containing signaling molecules that are substrates of three deiodinase isozymes, which catalyze the sequential reductive removal of iodine from the respective precursor molecule. Development of a analytical method applying liquid chromatography/tandem mass spectrometry, overview

718384

-

-

?

additional information

?

-

Rattus norvegicus

-

L-hormone analogues are preferentially deiodinated via the T4-5'-deiodination pathway, whereas D-analogues produce products via the T4-5-deiodination pathway

639396

-

-

?