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1.21.99.4: thyroxine 5'-deiodinase

This is an abbreviated version!
For detailed information about thyroxine 5'-deiodinase, go to the full flat file.

Word Map on EC 1.21.99.4

Reaction

3,3',5-triiodo-L-thyronine
+
Iodide
+
acceptor
+
H+
=
L-thyroxine
+
reduced acceptor

Synonyms

5DI , 5DII , 5DIII , D1 5'-deiodinase, D2 5'-deiodinase, deiodinase, diiodothyronine 5'-deiodinase, Dio, DIO1, DIO2, DIOI , DIOII , DIOIII , EC 1.97.1.10, EC 3.8.1.4, ID-1, ID-2, ID-3, iodothyronine 5'-deiodinase, Iodothyronine 5'-monodeiodinase, iodothyronine 5-deiodinase, iodothyronine deiodinase 2, iodothyronine deiodinase D2, iodothyronine inner ring monodeiodinase, iodothyronine outer ring monodeiodinase, L-thyroxine iodohydrolase (reducing), thyroxine 5-deiodinase, Thyroxine deiodinase, type 1 5'-deiodinase, type 1 deiodinase, Type 1 DI , type 1 iodothyronine deiodinase, type 2 5'-deiodinase, type 2 deiodinase, Type 2 DI , type 2 iodothyronine deiodinase, type 3 deiodinase, Type 3 DI , type I iodothyronine 5'-deiodinase, type I iodothyronine deiodinase, type I-like deiodinase, type II iodothyronine deiodinase, type II-like deiodinase, Type-I 5'deiodinase , Type-II 5'deiodinase , Type-III 5'deiodinase , types 1 iodothyronine selenodeiodinase, types 2 iodothyronine selenodeiodinase, XL-15

ECTree

     1 Oxidoreductases
         1.21 Catalysing the reaction X-H + Y-H = X-Y
             1.21.99 With unknown physiological acceptors
                1.21.99.4 thyroxine 5'-deiodinase

IC50 Value

IC50 Value on EC 1.21.99.4 - thyroxine 5'-deiodinase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.001
(2E)-2-(3,4-dihydroxybenzylidene)-4,6-dihydroxy-1-benzofuran-3(2H)-one
Rattus norvegicus
-
pH 7.4, 37°C
0.01
(2E)-2-(3,4-dihydroxybenzylidene)-6-hydroxy-1-benzofuran-3(2H)-one
Rattus norvegicus
-
pH 7.4, 37°C
0.0005
(2E)-4,6-dihydroxy-2-(4-hydroxy-3-iodobenzylidene)-1-benzofuran-3(2H)-one
Rattus norvegicus
-
pH 7.4, 37°C
0.001
(2E)-4,6-dihydroxy-2-(4-hydroxybenzylidene)-1-benzofuran-3(2H)-one
Rattus norvegicus
-
pH 7.4, 37°C
0.005
(4-[(E)-(4,6-dihydroxy-3-oxo-1-benzofuran-2(3H)-ylidene)methyl]phenoxy)acetic acid
Rattus norvegicus
-
pH 7.4, 37°C
0.008
2-(3,4-dihydroxybenzyl)-4,6-dihydroxy-1-benzofuran-3(2H)-one
Rattus norvegicus
-
pH 7.4, 37°C
0.003
2-amino-3-[4-[(4-hydroxy-3,5-diiodophenyl)thio]-3,5-diiodophenyl]propanoate
Rattus norvegicus
-
-
0.001
3',5'-diiodothyronine
Rattus norvegicus
-
pH 7.4, 37°C
0.0003
3,3',5'-triiodothyronine
Rattus norvegicus
-
pH 7.4, 37°C
0.008
3,5,3'-triiodo-5'-nitrothyronine
Rattus norvegicus
-
pH 7.4, 37°C
0.007
3,5,5'-triiodo-2'-methylthyronine
Rattus norvegicus
-
pH 7.4, 37°C
0.008
3,5-diiodo-2'-hydroxythyronine
Rattus norvegicus
-
pH 7.4, 37°C
0.014
3,5-diiodo-3',5'-dinitrothyronine
Rattus norvegicus
-
pH 7.4, 37°C
0.013
3,5-diiodo-3'-hydroxythyronine
Rattus norvegicus
-
pH 7.4, 37°C
0.012
3,5-diiodo-4'-amino-3',5'-dimethylthyronine
Rattus norvegicus
-
pH 7.4, 37°C
0.008
aurothioglucose
Rattus norvegicus
-
pH 7.4, 37°C
0.002
ethyl 4-(4-hydroxy-3,5-diiodobenzoyl)phenyl carbonate
Rattus norvegicus
-
pH 7.4, 37°C
0.0015
N-acetyl-3,5,3'-triiodo-5'-nitrothyronine
Rattus norvegicus
-
pH 7.4, 37°C
0.007
N-acetyl-3,5-diiodo-3',5'-dinitrothyronine
Rattus norvegicus
-
pH 7.4, 37°C
0.004
N-acetyl-3,5-diiodo-3'-bromo-5'-nitrothyronine
Rattus norvegicus
-
pH 7.4, 37°C
0.005 - 0.01
propylthiouracil
Felis catus
-
native and recombinant enzyme, IC50: 0.005-0.01 mM
0.0002
Tetraiodothyroacetic acid
Rattus norvegicus
-
pH 7.4, 37°C
0.0003
[4-(4-hydroxy-3,5-diiodophenoxy)phenyl]acetic acid
Rattus norvegicus
-
pH 7.4, 37°C
0.0015
[4-(4-hydroxy-3,5-dinitrophenoxy)-3,5-diiodophenyl]acetic acid
Rattus norvegicus
-
pH 7.4, 37°C
0.0005
[4-(4-hydroxy-3-iodo-5-nitrophenoxy)-3,5-diiodophenyl]acetate
Rattus norvegicus
-
pH 7.4, 37°C
0.0008
[4-(4-hydroxy-3-iodo-5-nitrophenoxy)phenyl]acetic acid
Rattus norvegicus
-
pH 7.4, 37°C