1.21.4.4: betaine reductase
This is an abbreviated version!
For detailed information about betaine reductase, go to the full flat file.
Word Map on EC 1.21.4.4
-
1.21.4.4
-
carnitine
-
choline
-
microbiota
-
metagenomic
-
dysbiosis
-
trimethylamine-n-oxide
- 1.21.4.4
- carnitine
- choline
- microbiota
-
metagenomic
-
dysbiosis
- trimethylamine-n-oxide
Reaction
Synonyms
reductase, betaine
ECTree
Advanced search results
Systematic Name
Systematic Name on EC 1.21.4.4 - betaine reductase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
acetyl-phosphate trimethylamine:thioredoxin disulfide oxidoreductase (N,N,N-trimethylglycine-forming)
The reaction is observed only in the direction of betaine reduction. The enzyme from Eubacterium acidaminophilum consists of subunits A, B and C. Subunit B contains selenocysteine and a pyruvoyl group, and is responsible for betaine binding and trimethylamine release. Subunit A, which also contains selenocysteine, is reduced by thioredoxin, and is needed to convert the carboxymethyl group into a ketene equivalent, in turn used by subunit C to produce acetyl phosphate. Only subunit B distinguishes this enzyme from EC 1.21.4.2 (glycine reductase) and EC 1.21.4.3 (sarcosine reductase).