1.21.1.1: iodotyrosine deiodinase

This is an abbreviated version!
For detailed information about iodotyrosine deiodinase, go to the full flat file.

Word Map on EC 1.21.1.1

1.21.1.1

thyroid

iodide

deiodination

hypothyroidism

diiodotyrosine

thyroglobulin

dehalogenation

halotyrosines

iodothyronine

nitroreductase

goiter

bromo

chlorotyrosine

organification

diagnostics

synthesis

medicine

Reaction

Synonyms

DEHAL1, Dehal1 protein, DEHAL1B, EC 1.22.1.1, iodotyrosine dehalogenase 1, iodotyrosine deiodinase, IYD, lyd, NADH oxidase/flavin reductase, SUP-18, SUP-18 IYD, TDH

ECTree

1 Oxidoreductases

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.1.1 iodotyrosine deiodinase

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Results	in table
7	Activating Compound
892	AA Sequence
4	Application
12	Cloned(Commentary)
25	Cofactor
5	Crystallization (Commentary)
69	Disease/ Diagnostics
6	Expression
15	General Information
6	IC50 Value
38	Inhibitors
14	kcat/KM [mM/s]
25	KM Value [mM]
10	Localization
8	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
199	Organism
14	PDB ID
2	pH Optimum
1	pH Range
1	Posttranslational Modification
20	Protein Variants
10	Purification (Commentary)
3	Reaction
33	Reference
2	Renatured (Commentary)
35	Source Tissue
16	Specific Activity [micromol/min/mg]
2	Storage Stability
60	Substrates and Products (Substrate)
9	Subunits
22	Synonyms
1	Systematic Name
17	Turnover Number [1/s]

KM Value

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KM Value on EC 1.21.1.1 - iodotyrosine deiodinase

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4.1

2-iodophenol

Homo sapiens

F4KU78

pH and temperature not specified in the publication

744363

0.0011 - 0.44

3,5-diiodo-L-tyrosine

8 entries

0.008

3-bromo-L-tyrosine

Drosophila melanogaster

E1JIB2

at pH 7.4, temperature not specified in the publication

746394

0.021

3-chloro-L-tyrosine

Drosophila melanogaster

E1JIB2

at pH 7.4, temperature not specified in the publication

746394

0.001 - 0.05

3-iodo-L-tyrosine

11 entries

0.027

NADPH

Rattus norvegicus

method 125I release, pH 7.4, 37°C

704839

additional information

3 entries