1.21.1.1: iodotyrosine deiodinase

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For detailed information about iodotyrosine deiodinase, go to the full flat file.

Reaction

Synonyms

DEHAL1, Dehal1 protein, DEHAL1B, EC 1.22.1.1, iodotyrosine dehalogenase 1, iodotyrosine deiodinase, IYD, lyd, NADH oxidase/flavin reductase, SUP-18, SUP-18 IYD, TDH

ECTree

     1 Oxidoreductases

         1.21 Catalysing the reaction X-H + Y-H = X-Y

             1.21.1 With NAD⁺ or NADP⁺ as acceptor

                1.21.1.1 iodotyrosine deiodinase

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Results	in table
7	Activating Compound
892	AA Sequence
4	Application
12	Cloned(Commentary)
25	Cofactor
5	Crystallization (Commentary)
69	Disease/ Diagnostics
6	Expression
15	General Information
6	IC50 Value
38	Inhibitors
14	kcat/KM [mM/s]
25	KM Value [mM]
10	Localization
8	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
199	Organism
14	PDB ID
2	pH Optimum
1	pH Range
1	Posttranslational Modification
20	Protein Variants
10	Purification (Commentary)
3	Reaction
33	Reference
2	Renatured (Commentary)
35	Source Tissue
16	Specific Activity [micromol/min/mg]
2	Storage Stability
60	Substrates and Products (Substrate)
9	Subunits
22	Synonyms
1	Systematic Name
17	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 1.21.1.1 - iodotyrosine deiodinase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.017

4-hydroxy-2',3,4',5,6'-pentachlorobiphenyl

Homo sapiens

-

pH 7.4, 25°C

728830

0.011

benzbromarone

Homo sapiens

-

pH 7.4, 25°C

728830

0.0008

erythrosine B

Homo sapiens

-

pH 7.4, 25°C

728830

0.0008

phloxine B

Homo sapiens

-

pH 7.4, 25°C

728830

0.0002

Rose bengal

Homo sapiens

-

pH 7.4, 25°C

728830

0.019

triclosan

Homo sapiens

-

pH 7.4, 25°C

728830