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1.21.1.1: iodotyrosine deiodinase

This is an abbreviated version!
For detailed information about iodotyrosine deiodinase, go to the full flat file.

Word Map on EC 1.21.1.1

Reaction

3-iodo-L-tyrosine
+
NADP+
+
Iodide
=
3,5-diiodo-L-tyrosine
+
NADPH
+
H+

Synonyms

DEHAL1, Dehal1 protein, DEHAL1B, EC 1.22.1.1, iodotyrosine dehalogenase 1, iodotyrosine deiodinase, IYD, lyd, NADH oxidase/flavin reductase, SUP-18, SUP-18 IYD, TDH

ECTree

     1 Oxidoreductases
         1.21 Catalysing the reaction X-H + Y-H = X-Y
             1.21.1 With NAD+ or NADP+ as acceptor
                1.21.1.1 iodotyrosine deiodinase

Engineering

Engineering on EC 1.21.1.1 - iodotyrosine deiodinase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
G258D
a naturally occuring sup-18 loss-of-function mutation
G258S
a naturally occuring sup-18 loss-of-function mutation
G280R
a naturally occuring sup-18 loss-of-function mutation
R289K
a naturally occuring sup-18 loss-of-function mutation
S137N
a naturally occuring sup-18 loss-of-function mutation
T271I
a naturally occuring sup-18 loss-of-function mutation
T322P
a naturally occuring sup-18 loss-of-function mutation
E154Q
the mutation diminishes the affinity of the enzyme for 3,5-diiodo-L-tyrosine by 30fold
K179Q
the mutation diminishes the affinity of the enzyme for 3,5-diiodo-L-tyrosine by 46fold
Y158F
the mutation results in a 7fold decrease in the enzyme's affinity for 3,5-diiodo-L-tyrosine
A220T
naturally occuring mutation involved in iodotyrosine deiodinase
I116T
naturally occuring mutation involved in iodotyrosine deiodinase deficiency, the mutant shows highly reduced activity compared to te wild-type enzyme
R101W
naturally occuring mutation involved in iodotyrosine deiodinase deficiency, the mutant shows highly reduced activity compared to te wild-type enzyme
E153Q
K178Q
upon expression in Escherichia coli, inactive and insoluble
Y157F
additional information