1.2.4.4: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) This is an abbreviated version! For detailed information about 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring), go to the full flat file .
Reaction
3-methyl-2-oxobutanoate +
[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine =
[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine +
CO2 +
2 H+
Synonyms 2-oxoisocaproate dehydrogenase, 2-oxoisovalerate dehydrogenase, 2-oxoisovalerate dehydrogenase (lipoate), 2-oxoisovalerate dehydrogenase subunit alpha, alpha-keto-beta-methylvalerate dehydrogenase, alpha-ketoacid dehydrogenase, alpha-ketoisocaproate dehydrogenase, alpha-ketoisocaproic dehydrogenase, alpha-ketoisocaproic-alpha-keto-beta-methylvaleric dehydrogenase, alpha-ketoisovalerate dehydrogenase, alpha-oxoisocaproate dehydrogenase, BCDH, BCKA dehydrogenase, BCKADC, BCKD, BCKDC, BCKDH, BCKDH E1-alpha, BCKDH E1-beta, BCKDHA, BCKDHB, BCKDHc, BCOA, BCOAD, BDKG, Bkd, bkdF, branched chain alpha-ketoacid dehydrogenase complex, branched chain keto acid dehydrogenase, branched-chain (-2-oxoacid BCD) dehydrogenase, branched-chain 2-keto acid dehydrogenase, branched-chain 2-oxo acid dehydrogenase, branched-chain alpha-keto acid decarboxylase/dehydrogenase, branched-chain alpha-keto acid dehydrogenase, branched-chain alpha-keto acid dehydrogenase complex, branched-chain alpha-keto acid dehydrogenase E1beta subunit, branched-chain alpha-ketoacid dehydrogenase, branched-chain alpha-ketoacid dehydrogenase complex, branched-chain alpha-ketoacid dehydrogenase enzyme complex, branched-chain alpha-ketoacid dehydrogenase multienzyme complex, branched-chain alpha-oxo acid dehydrogenase, branched-chain keto acid dehydrogenase, branched-chain keto acid dehydrogenase complex, branched-chain ketoacid dehydrogenase, branched-chain ketoacid dehydrogenase E1, dehydrogenase, 2-oxoisocaproate, dehydrogenase, 2-oxoisovalerate (lipoate), dehydrogenase, branched chain alpha-keto acid, DHalpha, dihydrolipoyl acyl-transferase, dihydrolipoyl transacylase, E1b, E1b component, E1b component of the 2-oxo acid dehydrogenase complex, E2, EC 1.2.4.3, More
ECTree
KM Value
KM Value on EC 1.2.4.4 - 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
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0.0133
2-oxo-4-methylthiobutanoate
-
-
0.028 - 4.38
2-oxo-isovalerate
0.0075 - 0.056
2-oxobutanoate
0.29 - 2.5
2-oxoglutarate
0.00067 - 0.568
3-methyl-2-oxobutanoate
0.01 - 0.25
3-methyl-2-oxopentanoate
0.0062 - 0.2
4-methyl-2-oxopentanoate
0.0105 - 0.0172
DL-3-methyl-2-oxopentanoate
0.00055 - 0.04
thiamine diphosphate
additional information
additional information
-
0.028
2-oxo-isovalerate
-
E1b component mutant S302Aalpha
0.048
2-oxo-isovalerate
-
wild-type E1b component
0.05
2-oxo-isovalerate
-
recombinant wild-type component E1b, and mutant D295Aalpha, pH 7.5, 22°C
0.059
2-oxo-isovalerate
-
recombinant wild-type E1b component, pH 7.5, 22°C
0.118
2-oxo-isovalerate
-
recombinant E1b component mutant H291Nalpha, pH 7.5, 22°C
0.119
2-oxo-isovalerate
-
wild type enzyme
0.193
2-oxo-isovalerate
-
E1b component mutant S292Nalpha
0.203
2-oxo-isovalerate
-
recombinant E1b component mutant H291Qalpha, pH 7.5, 22°C
0.206
2-oxo-isovalerate
-
recombinant E1b component mutant H291Aalpha, pH 7.5, 22°C
0.23
2-oxo-isovalerate
-
recombinant component E1b mutant R301Aalpha, pH 7.5, 22°C
0.25
2-oxo-isovalerate
-
recombinant component E1b mutant Y300Falpha, pH 7.5, 22°C
0.34
2-oxo-isovalerate
-
recombinant component E1b mutant Y300Aalpha, pH 7.5, 22°C
2.33
2-oxo-isovalerate
-
recombinant component E1b mutant R287Aalpha, pH 7.5, 22°C
4.38
2-oxo-isovalerate
-
E1b component mutant S292Dalpha
0.0075
2-oxobutanoate
-
-
0.0258
2-oxobutanoate
-
-
0.29
2-oxoglutarate
-
-
0.00067
3-methyl-2-oxobutanoate
-
-
0.0106
3-methyl-2-oxobutanoate
-
-
0.011
3-methyl-2-oxobutanoate
-
-
0.013
3-methyl-2-oxobutanoate
-
-
0.0156
3-methyl-2-oxobutanoate
-
-
0.028
3-methyl-2-oxobutanoate
-
-
0.0372
3-methyl-2-oxobutanoate
-
-
0.04
3-methyl-2-oxobutanoate
-
-
0.056
3-methyl-2-oxobutanoate
-
wild-type enzyme and mutant enzyme D297A
0.058
3-methyl-2-oxobutanoate
-
mutant enzyme T294A
0.059
3-methyl-2-oxobutanoate
-
mutant enzyme G290A and S298A
0.062
3-methyl-2-oxobutanoate
-
mutant enzyme I289A and H291A
0.064
3-methyl-2-oxobutanoate
-
mutant enzyme S295A
0.091
3-methyl-2-oxobutanoate
-
-
0.213
3-methyl-2-oxobutanoate
-
-
0.46
3-methyl-2-oxobutanoate
-
-
0.568
3-methyl-2-oxobutanoate
-
mutant enzyme S293A
0.01
3-methyl-2-oxopentanoate
-
-
0.014
3-methyl-2-oxopentanoate
-
-
0.0199
3-methyl-2-oxopentanoate
-
-
0.0219
3-methyl-2-oxopentanoate
-
-
0.037
3-methyl-2-oxopentanoate
-
-
0.25
3-methyl-2-oxopentanoate
-
-
0.0062
4-methyl-2-oxopentanoate
-
-
0.0087
4-methyl-2-oxopentanoate
-
-
0.011
4-methyl-2-oxopentanoate
-
-
0.0146
4-methyl-2-oxopentanoate
-
-
0.015
4-methyl-2-oxopentanoate
-
-
0.0215
4-methyl-2-oxopentanoate
-
-
0.0218
4-methyl-2-oxopentanoate
-
-
0.05
4-methyl-2-oxopentanoate
-
-
0.2
4-methyl-2-oxopentanoate
-
-
0.033
coenzyme A
-
-
0.0105
DL-3-methyl-2-oxopentanoate
-
-
0.0172
DL-3-methyl-2-oxopentanoate
-
-
0.03
NAD+
-
-
0.0387
NAD+
-
reaction with DL-3-methyl-2-oxopentanoate
0.0395
NAD+
-
reaction with 3-methyl-2-oxobutanoate
0.0423
NAD+
-
reaction with 4-methyl-2-oxopentanoate
0.12
NAD+
-
reaction with 3-methyl-2-oxobutanoate
0.173
pyruvate
-
-
0.00055
thiamine diphosphate
-
recombinant wild-type E1b component, pH 7.5, 22°C
0.0014
thiamine diphosphate
-
recombinant E1b component mutant H291Nalpha, pH 7.5, 22°C
0.007
thiamine diphosphate
-
recombinant wild-type component E1b, pH 7.5, 22°C
0.009
thiamine diphosphate
-
recombinant E1b component mutant H291Qalpha, pH 7.5, 22°C
0.017
thiamine diphosphate
-
recombinant component E1b mutant D295Aalpha, pH 7.5, 22°C
0.024
thiamine diphosphate
-
recombinant component E1b mutant R287Aalpha, pH 7.5, 22°C
0.024
thiamine diphosphate
-
recombinant E1b component mutant H291Aalpha, pH 7.5, 22°C
0.029
thiamine diphosphate
-
recombinant component E1b mutants R301Aalpha and Y300Falpha, pH 7.5, 22°C
0.04
thiamine diphosphate
-
recombinant component E1b mutant Y300Aalpha, pH 7.5, 22°C
additional information
additional information
-
-
-
additional information
additional information
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-
-
additional information
additional information
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-
-
additional information
additional information
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binding between E1b, wild-type and mutant, and E2b/lipoic acid-bearing domain components and thermodynamics, overall reaction kinetics, overview
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additional information
additional information
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kinetics of the overall reaction, thermodynamics and dissociation constants of interaction between component E1b and the lipoic acid-bearing domain of component E2b
-
additional information
additional information
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kinetics, wild-type and mutant E1b components
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additional information
additional information
thermodynamics
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additional information
additional information
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thermodynamics
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