1.2.1.9: glyceraldehyde-3-phosphate dehydrogenase (NADP+)
This is an abbreviated version!
For detailed information about glyceraldehyde-3-phosphate dehydrogenase (NADP+), go to the full flat file.
Word Map on EC 1.2.1.9
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1.2.1.9
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groes
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chaperonins
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refolding
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atpase
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heat-shock
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co-chaperonins
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rhodanese
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groel-groes
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chloroplast
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heptameric
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tubulins
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double-ring
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encapsulate
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misfolded
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machine
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malate
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anti-hsp60
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equatorial
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t-complex
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rubisco
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cage
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toroid
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mg-atp
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co-chaperone
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cryo-electron
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endosymbiotic
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chlamydial
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amp-pnp
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atp-induced
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aphid
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endosymbionts
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molten
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hetero-oligomeric
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coarse-grained
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protein-folding
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back-to-back
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nonnative
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trachomatis
- 1.2.1.9
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groes
- chaperonins
-
refolding
- atpase
-
heat-shock
-
co-chaperonins
- rhodanese
- groel-groes
- chloroplast
-
heptameric
-
tubulins
-
double-ring
-
encapsulate
-
misfolded
-
machine
- malate
-
anti-hsp60
-
equatorial
-
t-complex
- rubisco
-
cage
-
toroid
- mg-atp
-
co-chaperone
-
cryo-electron
-
endosymbiotic
-
chlamydial
- amp-pnp
-
atp-induced
-
aphid
-
endosymbionts
-
molten
-
hetero-oligomeric
-
coarse-grained
-
protein-folding
-
back-to-back
-
nonnative
-
trachomatis
Reaction
Synonyms
ALDH11A3, apo-GAPDH, apo-glyceraldehyde-3-phosphate dehydrogenase, At2g24270, CagapC, CbgapC, CsgapC, dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate), E268A-GAPN, GAP dehydrogenase, GAPC, GAPDH, GAPDH (A4), GAPDHN, GAPN, glyceraldehyde 3-phosphate dehydrogenase, glyceraldehyde 3-phosphate dehydrogenase (NADP), glyceraldehyde 3-phosphate:NADP+ reductase, non-phosphorylating, glyceraldehyde phosphate dehydrogenase (NADP), glyceraldehyde-3-phosphate dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase (NADP+), Glyceraldehyde-3-phosphate dehydrogenase [NADP+], glyceraldehyde-3-phosphate:NADP reductase, NADP+-dependent GAPDH, NADP+-dependent glyceraldehyde 3-phosphate dehydrogenase, NADP+-GAPDH, NADP-ALDH11A3, NADP-dependent ALDH11A3, NADP-dependent glyceraldehyde 3-phosphate dehydrogenase, NADP-dependent glyceraldehyde-3-phosphate dehydrogenase, NADP-dependent nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase, NADP-glyceraldehyde phosphate dehydrogenase, NADP-glyceraldehyde-3-phosphate dehydrogenase, NADPH-dependent GAPDH, NADPH-glyceraldehyde-3-phosphate dehydrogenase, non phosphorylating glyceraldehyde-3-phosphate dehydrogenase, non-phosphorylating GAP dehydrogenase, Non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase, non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase, non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase GAPN, non-phosphorylating glyceraldehyde-phosphate dehydrogenase, non-phosphorylating NADP+-dependent Ga3PDHase, non-phosphorylating NADP+-dependent glyceraldehyde-3-phosphate dehydrogenase, non-phosphorylating NADP-dependent glyceraldehyde-3-phosphate dehydrogenase, nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase, nonphosphorylating NADP-dependent glyceraldehyde-3-phosphate dehydrogenase, NP-Ga3PDHase, NP-GAPDH, OsALDH11, SSO3194, St-GAPN, STK_24770, triose phosphate dehydrogenase, Triosephosphate dehydrogenase
ECTree
1.2.1.9 glyceraldehyde-3-phosphate dehydrogenase (NADP+)Advanced search results
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results (Inhibitors
Inhibitors on EC 1.2.1.9 - glyceraldehyde-3-phosphate dehydrogenase (NADP+)
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
chloroplast protein CP12
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the chloroplast protein CP12 behaves as a negative regulator of GAPDH activity
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diphosphate
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after interaction with the 14-3-3 regulatory protein the phosphorylated enzyme exhibits higher sensitivity to inhibition
galactonate
slight inhibition; slight inhibition (1.2 to 1.3fold); slight inhibition (1.2 to 1.3fold)
hydrazin
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protonated and neutral form, compete with the attacking water molecule for the binding site E268, inhibition mechanism
hydroxylamine
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protonated and neutral form, compete with the attacking water molecule for the binding site E268, inhibition mechanism
SIN-1
causes Tyr nitration which causes inhibition of activity, a mass spectrometric analysis identifies Tyr318 as the best candidate
ATP
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after interaction with the 14-3-3 regulatory protein the phosphorylated enzyme exhibits higher sensitivity to inhibition
Diamide
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the inhibition with diamide is reversed by addition of dithiothreitol
Diamide
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sensitive to inactivation by diamide, inactivation is protected by D-glyceraldehyde 3-phosphate (with no effect by NADP+) and it is completely reversed by 2-mercaptoethanol
L-Glyceraldehyde 3-phosphate
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competitive below 0.04 mM, non-competitive above 0.075 mM
Mg2+
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near 75% of the activity is lost when 5 mM Mg2+ is included in the incubation medium
Mg2+
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near 75% of the activity is lost when 5 mM Mg2+ is included in the incubation medium
NADPH
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NADPH causes a large inhibition in enzyme activity even at very low concentrations (0.01-0.02?mM)
NADPH
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under oxidized conditions, NADPH causes a large inhibition in enzyme activity even at very low concentrations (0.01-0.02 mM)
additional information
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glyceraldehyde and ADP have no effect on GAPN activity; not inhibited by glyceraldehyde and ADP; not inhibited by glyceraldehyde and ADP
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additional information
glyceraldehyde and ADP have no effect on GAPN activity; not inhibited by glyceraldehyde and ADP; not inhibited by glyceraldehyde and ADP
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additional information
glyceraldehyde and ADP have no effect on GAPN activity; not inhibited by glyceraldehyde and ADP; not inhibited by glyceraldehyde and ADP
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additional information
glyceraldehyde and ADP have no effect on GAPN activity; not inhibited by glyceraldehyde and ADP; not inhibited by glyceraldehyde and ADP
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additional information
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no effect: ADP, AMP, D-glucose 6-phosphate and D-galactose 1-phosphate
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additional information
no effect: ADP, AMP, D-glucose 6-phosphate and D-galactose 1-phosphate
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