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1.2.1.88: L-glutamate gamma-semialdehyde dehydrogenase

This is an abbreviated version!
For detailed information about L-glutamate gamma-semialdehyde dehydrogenase, go to the full flat file.

Word Map on EC 1.2.1.88

Reaction

L-glutamate 5-semialdehyde
+
NAD+
+
H2O
=
L-glutamate
+
NADH
+
H+

Synonyms

1-pyrroline dehydrogenase, aldehyde dehydrogenase 12, ALDH12, Aldh4a1, dehydrogenase, 1-pyrroline-5-carboxylate, DELTA1-pyrroline-5-carboxylate dehydrogenase, delta1-pyrroline-5-carboxylate synthetase, DR_0813, EC 1.5.1.12, GSAL dehydrogenase, GSALDH, l-glutamate-gamma-semialdehyde dehydrogenase, L-pyrroline-5-carboxylate-NAD+ oxidoreductase, LRRP Ba1-651, NAD+-dependent glutamate gamma-semialdehyde dehydrogenase, OsALDH12, OsALDH18-2, P5C dehydrogenase, P5C synthase, P5C-DH, P5CD, P5CDH, P5CDH1, P5CS, PDH, PpALDH12, proline/P5C dehydrogenase, Put2, PutA, pyrroline-5-carboxylate dehydrogenase, pyrroline-5-carboxylate synthase, pyrroline-5-carboxylic acid dehydrogenase, Tc00.1047053510943.50, YcgN, ZmALDH12

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase

Inhibitors

Inhibitors on EC 1.2.1.88 - L-glutamate gamma-semialdehyde dehydrogenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
([[(3,5-dibromophenyl)methyl]amino]methylene)bis(phosphonic acid)
-
inhibits the growth of rapeseed seedlings and cultured cells with a strong reduction in glutamate and glutamate-related amino acid pools, but a milder effect on free proline. Toxic delta1-pyrroline-5-carboxylate levels accumulate in treated seedlings
-
([[(3,5-dichlorophenyl)methyl]amino]methylene)bis(phosphonic acid)
-
inhibits the growth of rapeseed seedlings and cultured cells, with a strong reduction in glutamate and glutamate-related amino acid pools, but a milder effect on free proline
-
2-aminopentanoate
-
-
4,5-Dehydro-L-pipecolic acid
-
baikiain, competitive
4-aminobutyrate
5-Aminopentanoate
-
-
6-aminohexanoate
-
-
arsenate
-
-
arsenite
Borate
-
-
Cd2+
-
-
chloride
cis-4-hydroxy-D-proline
weak inhibitor
CN-
-
-
Co2+
-
both isoforms, concentration above 3 mM
D-proline
weak inhibitor
DELTA1-pyrroline-2-carboxylate
-
-
fluoride
-
-
glyoxylate
-
Hg2+
-
both isoforms
imidazole
-
-
iodoacetamide
-
both isoforms
L-5-oxoproline
-
-
L-Ala
L-arginine
-
uncompetitive
L-Asp
L-Glu
L-glutamate
-
L-glutarate
-
L-His
L-hydroxyproline
L-Ile
L-Leu
L-proline
weak inhibitor
L-Ser
L-Trp
L-Val
Mn2+
-
-
N-ethylmaleimide
NADH
-
product inhibition
NH2OH
-
-
Ni2+
-
both isoforms
ornithine
-
inhibits only the short enzyme form
p-hydroxymercuribenzoate
piperidin-2-one
-
-
proline
-
both isoforms
succinate
-
sulfate
trans-4-hydroxy-D-proline
weak inhibitor
trans-4-hydroxy-L-proline
weak inhibitor
additional information
-