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1.2.1.88: L-glutamate gamma-semialdehyde dehydrogenase

This is an abbreviated version!
For detailed information about L-glutamate gamma-semialdehyde dehydrogenase, go to the full flat file.

Word Map on EC 1.2.1.88

Reaction

L-glutamate 5-semialdehyde
+
NAD+
 +
H2O
=
L-glutamate
 +
NADH
 +
H+

Synonyms

1-pyrroline dehydrogenase, aldehyde dehydrogenase 12, ALDH12, Aldh4a1, dehydrogenase, 1-pyrroline-5-carboxylate, DELTA1-pyrroline-5-carboxylate dehydrogenase, delta1-pyrroline-5-carboxylate synthetase, DR_0813, EC 1.5.1.12, GSAL dehydrogenase, GSALDH, l-glutamate-gamma-semialdehyde dehydrogenase, L-pyrroline-5-carboxylate-NAD+ oxidoreductase, LRRP Ba1-651, NAD+-dependent glutamate gamma-semialdehyde dehydrogenase, OsALDH12, OsALDH18-2, P5C dehydrogenase, P5C synthase, P5C-DH, P5CD, P5CDH, P5CDH1, P5CS, PDH, PpALDH12, proline/P5C dehydrogenase, Put2, PutA, pyrroline-5-carboxylate dehydrogenase, pyrroline-5-carboxylate synthase, pyrroline-5-carboxylic acid dehydrogenase, Tc00.1047053510943.50, YcgN, ZmALDH12

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase

Expression

Expression on EC 1.2.1.88 - L-glutamate gamma-semialdehyde dehydrogenase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
6fold upregulation during the infective stages of the parasite
ALDH12 expression in maize is downregulated in response to salt and drought stresses, possibly to maintain proline levels. Maize seedlings are also exposed to exogenous proline and arginine, and although ZmALDH12 transcript levels in roots do not significantly differ, ZmALDH12 levels in maize leaves are significantly altered: transcript levels are 5fold higher in response to arginine, but nearly 100fold lower in response to proline. This result may indicate an increased contribution of arginine catabolism to cellular glutamate in leaves. Addition of exogenous glutamate results in decreased ZmALDH12 expression in the shoot and increased expression in roots
ALDH12 expression in moss is downregulated in response to salt and drought stresses, possibly to maintain proline levels, with 200 mM NaCl or 400 mM sorbitol, PpALDH12 transcript levels are reduced
although ZmALDH12 transcript levels in roots do not significantly differ, ZmALDH12 levels in maize leaves are significantly altered: transcript levels are 5fold higher in response to arginine, but nearly 100fold lower in response to proline. This result may indicate an increased contribution of arginine catabolism to cellular glutamate in leaves. Addition of exogenous glutamate results in decreased ZmALDH12 expression in the shoot and increased expression in roots