1.2.1.85: 2-hydroxymuconate-6-semialdehyde dehydrogenase

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For detailed information about 2-hydroxymuconate-6-semialdehyde dehydrogenase, go to the full flat file.

Reaction

Synonyms

2-hydroxymuconate semialdehyde dehydrogenase, 2-hydroxymuconic semialdehyde dehydrogenase, 5C-2HMS dehydrogenase, HMS dehydrogenase, NAD+-dependent 2-hydroxy-muconic 6-semialdehyde dehydrogenase, NahI, praB, XylG

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.1 With NAD⁺ or NADP⁺ as acceptor

                1.2.1.85 2-hydroxymuconate-6-semialdehyde dehydrogenase

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Results	in table
780	AA Sequence
3	Cloned(Commentary)
3	Cofactor
1	Crystallization (Commentary)
7	General Information
6	Inhibitors
10	kcat/KM [mM/s]
12	KM Value [mM]
3	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
55	Organism
12	Pathway
3	pH Optimum
3	Purification (Commentary)
1	Reaction
12	Reference
4	Source Tissue
1	Specific Activity [micromol/min/mg]
25	Substrates and Products (Substrate)
6	Subunits
29	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.2.1.85 - 2-hydroxymuconate-6-semialdehyde dehydrogenase

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SYSTEMATIC NAME

IUBMB Comments

2-hydroxymuconate-6-semialdehyde:NAD+ oxidoreductase

This substrate for this enzyme is formed by meta ring cleavage of catechol (EC 1.13.11.2, catechol 2,3-dioxygenase), and is an intermediate in the bacterial degradation of several aromatic compounds. Has lower activity with benzaldehyde [1]. Activity with NAD+ is more than 10-fold higher than with NADP+ [3]. cf. EC 1.2.1.32, aminomuconate-semialdehyde dehydrogenase.