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1.2.1.85: 2-hydroxymuconate-6-semialdehyde dehydrogenase

This is an abbreviated version!
For detailed information about 2-hydroxymuconate-6-semialdehyde dehydrogenase, go to the full flat file.

Word Map on EC 1.2.1.85

Reaction

2-hydroxymuconate-6-semialdehyde
+
NAD+
+
H2O
=
(2Z,4E)-2-hydroxyhexa-2,4-dienedioate
+
NADH
+ 2 H+

Synonyms

2-hydroxymuconate semialdehyde dehydrogenase, 2-hydroxymuconic semialdehyde dehydrogenase, 5C-2HMS dehydrogenase, HMS dehydrogenase, NAD+-dependent 2-hydroxy-muconic 6-semialdehyde dehydrogenase, NahI, praB, XylG

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.85 2-hydroxymuconate-6-semialdehyde dehydrogenase

Substrates Products

Substrates Products on EC 1.2.1.85 - 2-hydroxymuconate-6-semialdehyde dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-hydroxy-5-methyl-6-oxohexa-2,4-dienoate + NAD+ + H2O
(2E,4Z)-2-hydroxy-5-methylhexa-2,4-diendioate + NADH + H+
show the reaction diagram
-
-
-
-
?
2-hydroxymuconate-6-semialdehyde + NAD+ + H2O
(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NADH + 2 H+
show the reaction diagram
2-hydroxymuconate-6-semialdehyde + NAD+ + H2O
(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NADH + H+
show the reaction diagram
3-chlorobenzaldehyde + NAD+ + H2O
3-chlorobenzoate + NADH + H+
show the reaction diagram
-
-
-
-
?
3-fluorobenzaldehyde + NAD+ + H2O
3-fluorobenzoate + NADH + H+
show the reaction diagram
-
-
-
-
?
3-methoxybenzaldehyde + NAD+ + H2O
3-methoxybenzoate + NADH + H+
show the reaction diagram
-
-
-
-
?
3-methylbenzaldehyde + NAD+ + H2O
3-methylbenzoate + NADH + H+
show the reaction diagram
-
-
-
-
?
3-nitrobenzaldehyde + NAD+ + H2O
3-nitrobenzoate + NADH + H+
show the reaction diagram
-
-
-
-
?
4-methylbenzaldehyde + NAD+ + H2O
4-methylbenzoate + NADH + H+
show the reaction diagram
-
-
-
-
?
5-chloro-2-hydroxymuconic semialdehyde + NAD+ + H2O
5-chloro-2-hydroxymuconic acid + NADH + H+
show the reaction diagram
acetaldehyde + NAD+ + H2O
acetate + NADH + H+
show the reaction diagram
-
113% activity compared to 2-hydroxymuconate-6-semialdehyde
-
-
?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
show the reaction diagram
butyraldehyde + NAD+ + H2O
butanoate + NADH + H+
show the reaction diagram
-
138% activity compared to 2-hydroxymuconate-6-semialdehyde
-
-
?
formaldehyde + NAD+ + H2O
formate + NADH + H+
show the reaction diagram
-
16.5% activity compared to 2-hydroxymuconate-6-semialdehyde
-
-
?
propionaldehyde + NAD+ + H2O
propanoate + NADH + H+
show the reaction diagram
-
107% activity compared to 2-hydroxymuconate-6-semialdehyde
-
-
?
additional information
?
-